5zc1 - Revision history

OCA at 21:18, 28 October 2020

OCA — Wed, 28 Oct 2020 21:18:03 GMT

←Older revision		Revision as of 21:18, 28 October 2020
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	==X-ray diffraction analysis of the CsStefin-1==		==X-ray diffraction analysis of the CsStefin-1==
-	<StructureSection load='5zc1' size='340' side='right' caption='[[5zc1]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='5zc1' size='340' side='right'caption='[[5zc1]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5zc1]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZC1 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ZC1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5zc1]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZC1 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5ZC1 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5zc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zc1 OCA], [http://pdbe.org/5zc1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zc1 RCSB], [http://www.ebi.ac.uk/pdbsum/5zc1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zc1 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5zc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zc1 OCA], [http://pdbe.org/5zc1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zc1 RCSB], [http://www.ebi.ac.uk/pdbsum/5zc1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zc1 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Jang, S B]]		[[Category: Jang, S B]]
	[[Category: Park, S Y]]		[[Category: Park, S Y]]

OCA at 08:12, 26 December 2018

OCA — Wed, 26 Dec 2018 08:12:23 GMT

←Older revision		Revision as of 08:12, 26 December 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 5zc1 is ~~ON HOLD until Paper~~ Publication	+	==X-ray diffraction analysis of the CsStefin-1==
		+	<StructureSection load='5zc1' size='340' side='right' caption='[[5zc1]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5zc1]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZC1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZC1 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zc1 OCA], [http://pdbe.org/5zc1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zc1 RCSB], [http://www.ebi.ac.uk/pdbsum/5zc1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zc1 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cystein protease plays a critical role as a virulence factor in the development and progression of various diseases. Cystatin is a superfamily of cysteine protease inhibitors that participates in various physiological and pathological processes. The cysteine protease inhibitor CsStein-1 isolated from Clonorchis sinensis belongs to the type 1 stefin of cystatins. This inhibitor regulates the activity and processing of CsCF (Cathepsin F of Clonorchis sienesis), which plays an important role in parasite nutrition and host-parasite interaction. CsStefin-1 has also been proposed as a host immune modulator and a participant in the mechanism associated with anti-inflammatory ability. Here, we report the first crystal structure of CsStefin-1 determined by the multi-wavelength anomalous diffraction (MAD) method to 2.3A. There are six molecules of CsStefin-1 per asymmetric unit, with a solvent content of 36.5%. The structure of CsStefin-1 is composed of twisted four-stranded antiparallel beta-sheets, a central alpha-helix, and a short alpha-helix. We also demonstrate that CsStefin-1 binds to CsCF-8 cysteine protease and inhibits its activity. In addition, a molecular docking model of CsStefin-1 and CsCF-8 was developed using homology modeling based on their structures. The structural information regarding CsStefin-1 and molecular insight into its interaction with CsCF-8 are important to understanding their biological function and to design of inhibitors that modulate cysteine protease activity.

-	~~Authors~~:	+	Structural basis of the cystein protease inhibitor Clonorchis sinensis Stefin-1.,Park SY, Jeong MS, Park SA, Ha SC, Na BK, Jang SB Biochem Biophys Res Commun. 2018 Mar 25;498(1):9-17. doi:, 10.1016/j.bbrc.2018.02.196. Epub 2018 Feb 28. PMID:29499196<ref>PMID:29499196</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5zc1" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Jang, S B]]
		+	[[Category: Park, S Y]]
		+	[[Category: Cscf]]
		+	[[Category: Csstefin-1]]
		+	[[Category: Cysteine protease inhibitor]]
		+	[[Category: Hydrolase inhibitor]]
		+	[[Category: Immune modulator]]

OCA: Protected "5zc1" [edit=sysop:move=sysop]

OCA — Wed, 18 Apr 2018 04:01:52 GMT

Protected "5zc1" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:01, 18 April 2018

OCA: New page: '''Unreleased structure''' The entry 5zc1 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 18 Apr 2018 04:01:50 GMT

New page: '''Unreleased structure''' The entry 5zc1 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5zc1 is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]