5zdl - Revision history

OCA at 08:51, 22 November 2023

OCA — Wed, 22 Nov 2023 08:51:57 GMT

←Older revision		Revision as of 08:51, 22 November 2023
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	<StructureSection load='5zdl' size='340' side='right'caption='[[5zdl]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='5zdl' size='340' side='right'caption='[[5zdl]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5zdl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZDL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5ZDL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5zdl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZDL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZDL FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ATP:ADENOSINE~~-~~5-TRIPHOSPHATE'>ATP</scene>~~, ~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>~~[http:~~/~~/en.wikipedia.org/wiki/Glutamine--tRNA_ligase Glutamine--tRNA ligase]~~, ~~with EC number [http~~:~~//www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.18 6.1.1.18]~~ </~~span~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5zdl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zdl OCA], [~~http~~://pdbe.org/5zdl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5zdl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5zdl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5zdl ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zdl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zdl OCA], [https://pdbe.org/5zdl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zdl RCSB], [https://www.ebi.ac.uk/pdbsum/5zdl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zdl ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q5SKU4_THET8 Q5SKU4_THET8]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 5zdl" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5zdl" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Aminoacyl tRNA synthetase 3D structures\|Aminoacyl tRNA synthetase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Glutamine--tRNA ligase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Jain, V]]	+	[[Category: Thermus thermophilus HB8]]
-	[[Category: Jeyaraman, J]]	+	[[Category: Jain V]]
-	[[Category: Manickam, Y]]	+	[[Category: Jeyaraman J]]
-	[[Category: Mutharasappan, N]]	+	[[Category: Manickam Y]]
-	[[Category: Sharma, A]]	+	[[Category: Mutharasappan N]]
-	~~[[Category: Glnr]]~~	+	[[Category: Sharma A]]
-	~~[[Category: Ligase]]~~	+
-	~~[[Category: Qr]]~~	+
-	~~[[Category: Synthetase~~]]	+

OCA at 21:18, 28 October 2020

OCA — Wed, 28 Oct 2020 21:18:44 GMT

←Older revision		Revision as of 21:18, 28 October 2020
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	==Crystal Structure Analysis of TtQRS in co-crystallised with ATP==		==Crystal Structure Analysis of TtQRS in co-crystallised with ATP==
-	<StructureSection load='5zdl' size='340' side='right' caption='[[5zdl]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='5zdl' size='340' side='right'caption='[[5zdl]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5zdl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZDL OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ZDL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5zdl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZDL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5ZDL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamine--tRNA_ligase Glutamine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.18 6.1.1.18] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamine--tRNA_ligase Glutamine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.18 6.1.1.18] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5zdl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zdl OCA], [http://pdbe.org/5zdl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zdl RCSB], [http://www.ebi.ac.uk/pdbsum/5zdl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zdl ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5zdl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zdl OCA], [http://pdbe.org/5zdl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zdl RCSB], [http://www.ebi.ac.uk/pdbsum/5zdl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zdl ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</StructureSection>		</StructureSection>
	[[Category: Glutamine--tRNA ligase]]		[[Category: Glutamine--tRNA ligase]]
		+	[[Category: Large Structures]]
	[[Category: Jain, V]]		[[Category: Jain, V]]
	[[Category: Jeyaraman, J]]		[[Category: Jeyaraman, J]]

OCA at 06:30, 5 December 2018

OCA — Wed, 05 Dec 2018 06:30:34 GMT

←Older revision		Revision as of 06:30, 5 December 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5zdl is ~~ON HOLD until Paper~~ Publication	+	==Crystal Structure Analysis of TtQRS in co-crystallised with ATP==
		+	<StructureSection load='5zdl' size='340' side='right' caption='[[5zdl]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5zdl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZDL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZDL FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamine--tRNA_ligase Glutamine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.18 6.1.1.18] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zdl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zdl OCA], [http://pdbe.org/5zdl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zdl RCSB], [http://www.ebi.ac.uk/pdbsum/5zdl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zdl ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Aminoacyl-tRNA synthetases (AaRSs) are vital enzymes for translation of proteins in cells. AaRSs catalyse the esterification of a specific amino acid to corresponding tRNAs to form an aminoacyl-tRNA that is used in ribosome-based protein synthesis. We focused on Glutaminyl tRNA synthetase (GlnRS) enzyme from the extreme thermophile Thermus thermophilus for structural studies. Our thermal shift assays show binding of enzyme substrates L-Gln and ATP as well as of various metals including cesium. We resolved crystal structures of apo-GlnRS as well as those in complex with AMP and ATP at 2.8A, 2.4A and 2.6A respectively. The bound cesium was found at the site of magnesium that typically binds to GlnRS. High structural conservation was evident in the Thermus thermophilus GlnRS when compared to those from Escherichia coli GlnRS.

-	~~Authors: Mutharasappan, N~~., ~~Jain~~, V., Sharma, A., ~~Manickam~~, Y., ~~Jeyaraman, J~~.	+	Structural and functional analysis of Glutaminyl-tRNA synthetase (TtGlnRS) from Thermus thermophilus HB8 and its complexes.,Nachiappan M, Jain V, Sharma A, Yogavel M, Jeyakanthan J Int J Biol Macromol. 2018 Dec;120(Pt B):1379-1386. doi:, 10.1016/j.ijbiomac.2018.09.115. Epub 2018 Sep 21. PMID:30248426<ref>PMID:30248426</ref>

-	~~Description: Crystal Structure Analysis~~ of ~~TtQRS in co~~-~~crystallised with ATP~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5zdl" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Glutamine--tRNA ligase]]
	[[Category: Jain, V]]		[[Category: Jain, V]]
-	[[Category: Manickam, Y]]
	[[Category: Jeyaraman, J]]		[[Category: Jeyaraman, J]]
		+	[[Category: Manickam, Y]]
	[[Category: Mutharasappan, N]]		[[Category: Mutharasappan, N]]
	[[Category: Sharma, A]]		[[Category: Sharma, A]]
		+	[[Category: Glnr]]
		+	[[Category: Ligase]]
		+	[[Category: Qr]]
		+	[[Category: Synthetase]]

OCA at 05:07, 28 March 2018

OCA — Wed, 28 Mar 2018 05:07:49 GMT

←Older revision		Revision as of 05:07, 28 March 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5zdl is ON HOLD	+	The entry 5zdl is ON HOLD until Paper Publication

	Authors: Mutharasappan, N., Jain, V., Sharma, A., Manickam, Y., Jeyaraman, J.		Authors: Mutharasappan, N., Jain, V., Sharma, A., Manickam, Y., Jeyaraman, J.

OCA: Protected "5zdl" [edit=sysop:move=sysop]

OCA — Wed, 28 Feb 2018 04:56:26 GMT

Protected "5zdl" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:56, 28 February 2018

OCA: New page: '''Unreleased structure''' The entry 5zdl is ON HOLD Authors: Mutharasappan, N., Jain, V., Sharma, A., Manickam, Y., Jeyaraman, J. Description: Crystal Structure Analysis of TtQRS in c...

OCA — Wed, 28 Feb 2018 04:56:25 GMT

New page: '''Unreleased structure''' The entry 5zdl is ON HOLD Authors: Mutharasappan, N., Jain, V., Sharma, A., Manickam, Y., Jeyaraman, J. Description: Crystal Structure Analysis of TtQRS in c...

New page

'''Unreleased structure'''

The entry 5zdl is ON HOLD

Authors: Mutharasappan, N., Jain, V., Sharma, A., Manickam, Y., Jeyaraman, J.

Description: Crystal Structure Analysis of TtQRS in co-crystallised with ATP
[[Category: Unreleased Structures]]
[[Category: Jain, V]]
[[Category: Manickam, Y]]
[[Category: Jeyaraman, J]]
[[Category: Mutharasappan, N]]
[[Category: Sharma, A]]