5zg4 - Revision history

OCA at 08:53, 22 November 2023

OCA — Wed, 22 Nov 2023 08:53:53 GMT

←Older revision		Revision as of 08:53, 22 November 2023
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	<StructureSection load='5zg4' size='340' side='right'caption='[[5zg4]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='5zg4' size='340' side='right'caption='[[5zg4]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5zg4]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZG4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5ZG4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5zg4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Opisthorchis_viverrini Opisthorchis viverrini]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZG4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZG4 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5zfx\|5zfx]]</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.746Å</td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~">~~<b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose~~-~~phosphate_isomerase Triose-phosphate isomerase]~~, ~~with EC number~~ [~~http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.~~1.~~1 5.3.1.1] </span>~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zg4 OCA], [https://pdbe.org/5zg4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zg4 RCSB], [https://www.ebi.ac.uk/pdbsum/5zg4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zg4 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5zg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zg4 OCA], [~~http~~://pdbe.org/5zg4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5zg4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5zg4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5zg4 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A074Z863_9TREM A0A074Z863_9TREM]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 5zg4" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5zg4" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Triose phosphate isomerase 3D structures\|Triose phosphate isomerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Triose-phosphate isomerase~~]]	+	[[Category: Opisthorchis viverrini]]
-	[[Category: Hwang~~, K Y~~]]	+	[[Category: Hwang KY]]
-	[[Category: Kim, S]]	+	[[Category: Kim S]]
-	[[Category: Kim~~, S E~~]]	+	[[Category: Kim SE]]
-	[[Category: Lee, H]]	+	[[Category: Lee H]]
-	[[Category: Lee~~, M R~~]]	+	[[Category: Lee MR]]
-	[[Category: Son, J]]	+	[[Category: Son J]]
-	~~[[Category: Isomerase]]~~	+
-	~~[[Category: Tim-barrel]]~~	+
-	~~[[Category: Triosephosphate isomerase~~]]	+

OCA at 21:19, 28 October 2020

OCA — Wed, 28 Oct 2020 21:19:22 GMT

←Older revision		Revision as of 21:19, 28 October 2020
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	==Crystal Structure of Triosephosphate isomerase SAD deletion mutant from Opisthorchis viverrini==		==Crystal Structure of Triosephosphate isomerase SAD deletion mutant from Opisthorchis viverrini==
-	<StructureSection load='5zg4' size='340' side='right' caption='[[5zg4]], [[Resolution\|resolution]] 1.75Å' scene=''>	+	<StructureSection load='5zg4' size='340' side='right'caption='[[5zg4]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5zg4]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZG4 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ZG4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5zg4]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZG4 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5ZG4 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5zfx\|5zfx]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5zfx\|5zfx]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5zg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zg4 OCA], [http://pdbe.org/5zg4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zg4 RCSB], [http://www.ebi.ac.uk/pdbsum/5zg4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zg4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5zg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zg4 OCA], [http://pdbe.org/5zg4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zg4 RCSB], [http://www.ebi.ac.uk/pdbsum/5zg4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zg4 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Triose-phosphate isomerase]]		[[Category: Triose-phosphate isomerase]]
	[[Category: Hwang, K Y]]		[[Category: Hwang, K Y]]

OCA at 05:47, 24 October 2018

OCA — Wed, 24 Oct 2018 05:47:24 GMT

←Older revision		Revision as of 05:47, 24 October 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 5zg4 is ~~ON HOLD until Paper~~ Publication	+	==Crystal Structure of Triosephosphate isomerase SAD deletion mutant from Opisthorchis viverrini==
		+	<StructureSection load='5zg4' size='340' side='right' caption='[[5zg4]], [[Resolution\|resolution]] 1.75Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5zg4]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZG4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZG4 FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5zfx\|5zfx]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zg4 OCA], [http://pdbe.org/5zg4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zg4 RCSB], [http://www.ebi.ac.uk/pdbsum/5zg4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zg4 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Opisthorchis viverrini, a parasitic trematode, was recategorized as a group 1 biological carcinogen because it causes opisthorchiasis, which may result in cholangiocarcinoma. A new strategy for controlling opisthorchiasis is needed because of issues such as drug resistance and reinfection. Triosephosphate isomerase (TIM), a key enzyme in energy metabolism, is regarded as a potential drug target and vaccine candidate against various pathogens. Here, we determined the crystal structures of wild-type and 3 variants of TIMs from O. viverrini (OvTIM) at high resolution. The unique tripeptide of parasite trematodes, the SAD motif, was located on the surface of OvTIM and contributed to forming a 310-helix of the following loop in a sequence-independent manner. Through thermal stability and structural analyses of OvTIM variants, we found that the SAD motif induced local structural alterations of the surface and was involved in the overall stability of OvTIM in a complementary manner with another parasite-specific residue, N115. Comparison of the surface characteristics between OvTIM and Homo sapiens TIM (HsTIM) and structure-based epitope prediction suggested that the SAD motif functions as an epitope.

-	~~Authors:~~ Son, J., Kim, S., Kim~~, S.~~, Lee, H., Lee, M.R.~~, Hwang, K~~.Y.	+	Structural Analysis of an Epitope Candidate of Triosephosphate Isomerase in Opisthorchis viverrini.,Son J, Kim S, Kim SE, Lee H, Lee MR, Hwang KY Sci Rep. 2018 Oct 10;8(1):15075. doi: 10.1038/s41598-018-33479-8. PMID:30305716<ref>PMID:30305716</ref>

-	~~Description: Crystal Structure~~ of ~~Triosephosphate isomerase SAD deletion mutant from Opisthorchis viverrini~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: ~~Son~~, J]]	+	<div class="pdbe-citations 5zg4" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Triose-phosphate isomerase]]
		+	[[Category: Hwang, K Y]]
	[[Category: Kim, S]]		[[Category: Kim, S]]
		+	[[Category: Kim, S E]]
	[[Category: Lee, H]]		[[Category: Lee, H]]
-	[[Category: ~~Hwang~~, ~~K.Y~~]]	+	[[Category: Lee, M R]]
-	[[Category: ~~Lee~~, ~~M.R~~]]	+	[[Category: Son, J]]
		+	[[Category: Isomerase]]
		+	[[Category: Tim-barrel]]
		+	[[Category: Triosephosphate isomerase]]

OCA at 06:31, 2 May 2018

OCA — Wed, 02 May 2018 06:31:41 GMT

←Older revision		Revision as of 06:31, 2 May 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5zg4 is ON HOLD	+	The entry 5zg4 is ON HOLD until Paper Publication

	Authors: Son, J., Kim, S., Kim, S., Lee, H., Lee, M.R., Hwang, K.Y.		Authors: Son, J., Kim, S., Kim, S., Lee, H., Lee, M.R., Hwang, K.Y.
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	Description: Crystal Structure of Triosephosphate isomerase SAD deletion mutant from Opisthorchis viverrini		Description: Crystal Structure of Triosephosphate isomerase SAD deletion mutant from Opisthorchis viverrini
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Son, J]]
	[[Category: Kim, S]]		[[Category: Kim, S]]
	[[Category: Lee, H]]		[[Category: Lee, H]]
	[[Category: Hwang, K.Y]]		[[Category: Hwang, K.Y]]
	[[Category: Lee, M.R]]		[[Category: Lee, M.R]]
-	[[Category: Son, J]]

OCA at 12:16, 11 April 2018

OCA — Wed, 11 Apr 2018 12:16:42 GMT

←Older revision		Revision as of 12:16, 11 April 2018
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	Authors: Son, J., Kim, S., Kim, S., Lee, H., Lee, M.R., Hwang, K.Y.		Authors: Son, J., Kim, S., Kim, S., Lee, H., Lee, M.R., Hwang, K.Y.

-	Description: Crystal Structure of Triosephosphate isomerase SAD deletion mutant from ~~Clonorchis sinensis~~	+	Description: Crystal Structure of Triosephosphate isomerase SAD deletion mutant from Opisthorchis viverrini
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Kim, S]]		[[Category: Kim, S]]

OCA: Protected "5zg4" [edit=sysop:move=sysop]

OCA — Wed, 14 Mar 2018 05:01:51 GMT

Protected "5zg4" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:01, 14 March 2018

OCA: New page: '''Unreleased structure''' The entry 5zg4 is ON HOLD Authors: Son, J., Kim, S., Kim, S., Lee, H., Lee, M.R., Hwang, K.Y. Description: Crystal Structure of Triosephosphate isomerase SAD...

OCA — Wed, 14 Mar 2018 05:01:50 GMT

New page: '''Unreleased structure''' The entry 5zg4 is ON HOLD Authors: Son, J., Kim, S., Kim, S., Lee, H., Lee, M.R., Hwang, K.Y. Description: Crystal Structure of Triosephosphate isomerase SAD...

New page

'''Unreleased structure'''

The entry 5zg4 is ON HOLD

Authors: Son, J., Kim, S., Kim, S., Lee, H., Lee, M.R., Hwang, K.Y.

Description: Crystal Structure of Triosephosphate isomerase SAD deletion mutant from Clonorchis sinensis
[[Category: Unreleased Structures]]
[[Category: Kim, S]]
[[Category: Lee, H]]
[[Category: Hwang, K.Y]]
[[Category: Lee, M.R]]
[[Category: Son, J]]