5zia - Revision history

OCA at 08:56, 22 November 2023

OCA — Wed, 22 Nov 2023 08:56:43 GMT

←Older revision		Revision as of 08:56, 22 November 2023
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	<StructureSection load='5zia' size='340' side='right'caption='[[5zia]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='5zia' size='340' side='right'caption='[[5zia]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5zia]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/ ~~] and [https://en.wikipedia.org/wiki/Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZIA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZIA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5zia]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZIA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZIA FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non~~-~~Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.603Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zia OCA], [https://pdbe.org/5zia PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zia RCSB], [https://www.ebi.ac.uk/pdbsum/5zia PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zia ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zia OCA], [https://pdbe.org/5zia PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zia RCSB], [https://www.ebi.ac.uk/pdbsum/5zia PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zia ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/TAU_HUMAN TAU_HUMAN] Note=In Alzheimer disease, the neuronal cytoskeleton in the brain is progressively disrupted and replaced by tangles of paired helical filaments (PHF) and straight filaments, mainly composed of hyperphosphorylated forms of TAU (PHF-TAU or AD P-TAU). O-GlcNAcylation is greatly reduced in Alzheimer disease brain cerebral cortex leading to an increase in TAU/MAPT phosphorylations.<ref>PMID:19451179</ref> <ref>PMID:2484340</ref> <ref>PMID:14517953</ref> Defects in MAPT are a cause of frontotemporal dementia (FTD) [MIM:[https://omim.org/entry/600274 600274]; also called frontotemporal dementia (FTD), pallido-ponto-nigral degeneration (PPND) or historically termed Pick complex. This form of frontotemporal dementia is characterized by presenile dementia with behavioral changes, deterioration of cognitive capacities and loss of memory. In some cases, parkinsonian symptoms are prominent. Neuropathological changes include frontotemporal atrophy often associated with atrophy of the basal ganglia, substantia nigra, amygdala. In most cases, protein tau deposits are found in glial cells and/or neurons.<ref>PMID:19451179</ref> <ref>PMID:2484340</ref> <ref>PMID:14517953</ref> <ref>PMID:9629852</ref> <ref>PMID:9736786</ref> <ref>PMID:9641683</ref> <ref>PMID:9789048</ref> <ref>PMID:9973279</ref> <ref>PMID:10553987</ref> <ref>PMID:10214944</ref> <ref>PMID:10374757</ref> <ref>PMID:10489057</ref> <ref>PMID:10208578</ref> <ref>PMID:11117541</ref> <ref>PMID:10802785</ref> <ref>PMID:11071507</ref> <ref>PMID:11585254</ref> <ref>PMID:11278002</ref> <ref>PMID:12473774</ref> <ref>PMID:11921059</ref> <ref>PMID:11906000</ref> <ref>PMID:11889249</ref> <ref>PMID:12509859</ref> <ref>PMID:16240366</ref> <ref>PMID:15883319</ref> Defects in MAPT are a cause of Pick disease of the brain (PIDB) [MIM:[https://omim.org/entry/172700 172700]. It is a rare form of dementia pathologically defined by severe atrophy, neuronal loss and gliosis. It is characterized by the occurrence of tau-positive inclusions, swollen neurons (Pick cells) and argentophilic neuronal inclusions known as Pick bodies that disproportionally affect the frontal and temporal cortical regions. Clinical features include aphasia, apraxia, confusion, anomia, memory loss and personality deterioration.<ref>PMID:19451179</ref> <ref>PMID:2484340</ref> <ref>PMID:14517953</ref> <ref>PMID:10604746</ref> <ref>PMID:11117542</ref> <ref>PMID:11089577</ref> <ref>PMID:11601501</ref> <ref>PMID:11891833</ref> Note=Defects in MAPT are a cause of corticobasal degeneration (CBD). It is marked by extrapyramidal signs and apraxia and can be associated with memory loss. Neuropathologic features may overlap Alzheimer disease, progressive supranuclear palsy, and Parkinson disease.<ref>PMID:19451179</ref> <ref>PMID:2484340</ref> <ref>PMID:14517953</ref> Defects in MAPT are a cause of progressive supranuclear palsy type 1 (PSNP1) [MIM:[https://omim.org/entry/601104 601104]; also abbreviated as PSP and also known as Steele-Richardson-Olszewski syndrome. PSNP1 is characterized by akinetic-rigid syndrome, supranuclear gaze palsy, pyramidal tract dysfunction, pseudobulbar signs and cognitive capacities deterioration. Neurofibrillary tangles and gliosis but no amyloid plaques are found in diseased brains. Most cases appear to be sporadic, with a significant association with a common haplotype including the MAPT gene and the flanking regions. Familial cases show an autosomal dominant pattern of transmission with incomplete penetrance; genetic analysis of a few cases showed the occurrence of tau mutations, including a deletion of Asn-613.<ref>PMID:19451179</ref> <ref>PMID:2484340</ref> <ref>PMID:14517953</ref> <ref>PMID:10534245</ref> <ref>PMID:11220749</ref> <ref>PMID:12325083</ref> <ref>PMID:14991829</ref> <ref>PMID:14991828</ref> <ref>PMID:16157753</ref> Defects in MAPT are a cause of Parkinson-dementia syndrome (PARDE) [MIM:[https://omim.org/entry/260540 260540]. A syndrome characterized by parkinsonism tremor, rigidity, dementia, ophthalmoparesis and pyramidal signs. Neurofibrillary degeneration occurs in the hippocampus, basal ganglia and brainstem nuclei.<ref>PMID:19451179</ref> <ref>PMID:2484340</ref> <ref>PMID:14517953</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TAU_HUMAN TAU_HUMAN] Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.<ref>PMID:21985311</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Wilson~~, I A~~]]	+	[[Category: Wilson IA]]
-	[[Category: Zhang, H]]	+	[[Category: Zhang H]]
-	~~[[Category: Antibody]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Tau protein~~]]	+

OCA at 11:36, 23 March 2022

OCA — Wed, 23 Mar 2022 11:36:23 GMT

←Older revision		Revision as of 11:36, 23 March 2022
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	<StructureSection load='5zia' size='340' side='right'caption='[[5zia]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='5zia' size='340' side='right'caption='[[5zia]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5zia]] is a 18 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZIA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ZIA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5zia]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/ ] and [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZIA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZIA FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5zia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zia OCA], [~~http~~://pdbe.org/5zia PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5zia RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5zia PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5zia ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zia OCA], [https://pdbe.org/5zia PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zia RCSB], [https://www.ebi.ac.uk/pdbsum/5zia PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zia ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 19:		Line 19:
	==See Also==		==See Also==
	*[[Antibody 3D structures\|Antibody 3D structures]]		*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[3D structures of human antibody\|3D structures of human antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:43, 25 December 2019

OCA — Wed, 25 Dec 2019 12:43:51 GMT

←Older revision		Revision as of 12:43, 25 December 2019
Line 1:		Line 1:

	==Crystal structure of human anti-tau antibody CBTAU-24.1 in complex with its phosphorylated tau peptide==		==Crystal structure of human anti-tau antibody CBTAU-24.1 in complex with its phosphorylated tau peptide==
-	<StructureSection load='5zia' size='340' side='right' caption='[[5zia]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='5zia' size='340' side='right'caption='[[5zia]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5zia]] is a 18 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZIA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZIA FirstGlance]. <br>		<table><tr><td colspan='2'>[[5zia]] is a 18 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZIA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZIA FirstGlance]. <br>
Line 16:		Line 16:
	</div>		</div>
	<div class="pdbe-citations 5zia" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5zia" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 21:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Wilson, I A]]		[[Category: Wilson, I A]]
	[[Category: Zhang, H]]		[[Category: Zhang, H]]

OCA at 08:32, 26 December 2018

OCA — Wed, 26 Dec 2018 08:32:21 GMT

←Older revision		Revision as of 08:32, 26 December 2018
Line 3:		Line 3:
	<StructureSection load='5zia' size='340' side='right' caption='[[5zia]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='5zia' size='340' side='right' caption='[[5zia]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5zia]] is a 18 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZIA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZIA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5zia]] is a 18 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZIA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZIA FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zia OCA], [http://pdbe.org/5zia PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zia RCSB], [http://www.ebi.ac.uk/pdbsum/5zia PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zia ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zia OCA], [http://pdbe.org/5zia PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zia RCSB], [http://www.ebi.ac.uk/pdbsum/5zia PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zia ProSAT]</span></td></tr>
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Wilson, I A]]		[[Category: Wilson, I A]]
	[[Category: Zhang, H]]		[[Category: Zhang, H]]

OCA at 06:46, 31 October 2018

OCA — Wed, 31 Oct 2018 06:46:12 GMT

←Older revision		Revision as of 06:46, 31 October 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5zia is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of human anti-tau antibody CBTAU-24.1 in complex with its phosphorylated tau peptide==
		+	<StructureSection load='5zia' size='340' side='right' caption='[[5zia]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5zia]] is a 18 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZIA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZIA FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zia OCA], [http://pdbe.org/5zia PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zia RCSB], [http://www.ebi.ac.uk/pdbsum/5zia PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zia ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Aggregation of the hyperphosphorylated protein tau into neurofibrillary tangles and neuropil threads is a hallmark of Alzheimer disease (AD). Identification and characterization of the epitopes recognized by anti-tau antibodies might shed light on the molecular mechanisms of AD pathogenesis. Here we report on the biochemical and structural characterization of a tau-specific monoclonal antibody CBTAU-24.1, which was isolated from the human memory B cell repertoire. Immunohistochemical staining with CBTAU-24.1 specifically detects pathological tau structures in AD brain samples. The crystal structure of CBTAU-24.1 Fab with a phosphorylated tau peptide revealed recognition of a unique epitope (Ser235-Leu243) in the tau proline-rich domain. Interestingly, the antibody can bind tau regardless of phosphorylation state of its epitope region and also recognizes both monomeric and paired helical filament tau irrespective of phosphorylation status. This human anti-tau antibody and its unique epitope may aid in development of diagnostics and/or therapeutic AD strategies.

-	~~Authors:~~ Zhang, H., Wilson, I.A.	+	Structural Basis for Recognition of a Unique Epitope by a Human Anti-tau Antibody.,Zhang H, Zhu X, Pascual G, Wadia JS, Keogh E, Hoozemans JJ, Siregar B, Inganas H, Stoop EJM, Goudsmit J, Apetri A, Koudstaal W, Wilson IA Structure. 2018 Sep 12. pii: S0969-2126(18)30326-5. doi:, 10.1016/j.str.2018.08.012. PMID:30318466<ref>PMID:30318466</ref>

-	~~Description: Crystal structure~~ of ~~human anti~~-~~tau antibody CBTAU~~-~~24.1 in complex with its phosphorylated tau peptide~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5zia" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Wilson, I A]]
	[[Category: Zhang, H]]		[[Category: Zhang, H]]
-	[[Category: ~~Wilson, I.A~~]]	+	[[Category: Antibody]]
		+	[[Category: Immune system]]
		+	[[Category: Tau protein]]

OCA at 04:02, 18 April 2018

OCA — Wed, 18 Apr 2018 04:02:25 GMT

←Older revision		Revision as of 04:02, 18 April 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5zia is ON HOLD	+	The entry 5zia is ON HOLD until Paper Publication

	Authors: Zhang, H., Wilson, I.A.		Authors: Zhang, H., Wilson, I.A.

OCA: Protected "5zia" [edit=sysop:move=sysop]

OCA — Wed, 21 Mar 2018 06:02:51 GMT

Protected "5zia" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:02, 21 March 2018

OCA: New page: '''Unreleased structure''' The entry 5zia is ON HOLD Authors: Zhang, H., Wilson, I.A. Description: Crystal structure of human anti-tau antibody CBTAU-24.1 in complex with its phosphory...

OCA — Wed, 21 Mar 2018 06:02:50 GMT

New page: '''Unreleased structure''' The entry 5zia is ON HOLD Authors: Zhang, H., Wilson, I.A. Description: Crystal structure of human anti-tau antibody CBTAU-24.1 in complex with its phosphory...

New page

'''Unreleased structure'''

The entry 5zia is ON HOLD

Authors: Zhang, H., Wilson, I.A.

Description: Crystal structure of human anti-tau antibody CBTAU-24.1 in complex with its phosphorylated tau peptide
[[Category: Unreleased Structures]]
[[Category: Zhang, H]]
[[Category: Wilson, I.A]]