5zid - Revision history

OCA at 08:56, 22 November 2023

OCA — Wed, 22 Nov 2023 08:56:46 GMT

←Older revision		Revision as of 08:56, 22 November 2023
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	<StructureSection load='5zid' size='340' side='right'caption='[[5zid]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='5zid' size='340' side='right'caption='[[5zid]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5zid]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZID OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ZID FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5zid]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZID OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZID FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9EL:(2S,3R)-2-amino-9-methoxy-3-(2,4,5-trifluorophenyl)-2,3-dihydro-1H-naphtho[2,1-b]pyran-8-carbonitrile'>9EL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DPP4, ADCP2, CD26 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9EL:(2S,3R)-2-amino-9-methoxy-3-(2,4,5-trifluorophenyl)-2,3-dihydro-1H-naphtho[2,1-b]pyran-8-carbonitrile'>9EL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zid OCA], [https://pdbe.org/5zid PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zid RCSB], [https://www.ebi.ac.uk/pdbsum/5zid PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zid ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5zid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zid OCA], [~~http~~://pdbe.org/5zid PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5zid RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5zid PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5zid ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/DPP4_HUMAN DPP4_HUMAN]] Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.<ref>PMID:10951221</ref> <ref>PMID:17549790</ref> <ref>PMID:10570924</ref> <ref>PMID:10900005</ref> <ref>PMID:11772392</ref> <ref>PMID:14691230</ref> <ref>PMID:16651416</ref> <ref>PMID:17287217</ref> <ref>PMID:18708048</ref>	+	[https://www.uniprot.org/uniprot/DPP4_HUMAN DPP4_HUMAN] Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.<ref>PMID:10951221</ref> <ref>PMID:17549790</ref> <ref>PMID:10570924</ref> <ref>PMID:10900005</ref> <ref>PMID:11772392</ref> <ref>PMID:14691230</ref> <ref>PMID:16651416</ref> <ref>PMID:17287217</ref> <ref>PMID:18708048</ref>
		+
		+	==See Also==
		+	*[[Dipeptidyl peptidase 3D structures\|Dipeptidyl peptidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Dipeptidyl-peptidase IV]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Li, H]]	+	[[Category: Li H]]
-	[[Category: Wu, F]]	+	[[Category: Wu F]]
-	[[Category: Zhu, L]]	+	[[Category: Zhu L]]
-	~~[[Category: Dpp-4]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Inhibitor complex~~]]	+

OCA at 06:33, 17 April 2019

OCA — Wed, 17 Apr 2019 06:33:28 GMT

←Older revision		Revision as of 06:33, 17 April 2019
Line 3:		Line 3:
	<StructureSection load='5zid' size='340' side='right'caption='[[5zid]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='5zid' size='340' side='right'caption='[[5zid]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5zid]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZID OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZID FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5zid]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZID OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZID FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9EL:(2S,3R)-2-amino-9-methoxy-3-(2,4,5-trifluorophenyl)-2,3-dihydro-1H-naphtho[2,1-b]pyran-8-carbonitrile'>9EL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9EL:(2S,3R)-2-amino-9-methoxy-3-(2,4,5-trifluorophenyl)-2,3-dihydro-1H-naphtho[2,1-b]pyran-8-carbonitrile'>9EL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DPP4, ADCP2, CD26 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zid OCA], [http://pdbe.org/5zid PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zid RCSB], [http://www.ebi.ac.uk/pdbsum/5zid PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zid ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zid OCA], [http://pdbe.org/5zid PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zid RCSB], [http://www.ebi.ac.uk/pdbsum/5zid PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zid ProSAT]</span></td></tr>
Line 15:		Line 16:
	</StructureSection>		</StructureSection>
	[[Category: Dipeptidyl-peptidase IV]]		[[Category: Dipeptidyl-peptidase IV]]
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Li, H]]		[[Category: Li, H]]

OCA at 07:40, 20 March 2019

OCA — Wed, 20 Mar 2019 07:40:54 GMT

←Older revision		Revision as of 07:40, 20 March 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5zid is ~~ON HOLD until Paper Publication~~	+	==Crystal Structure of human DPP-IV in complex with HL2==
-		+	<StructureSection load='5zid' size='340' side='right'caption='[[5zid]], [[Resolution\|resolution]] 3.00Å' scene=''>
-	~~Authors~~: ~~Zhu~~, L., Li, H., Wu, F.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5zid]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZID OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZID FirstGlance]. <br>
-	~~Description~~: ~~Crystal Structure~~ of ~~human DPP~~-IV in ~~complex~~ with ~~HL2~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9EL:(2S,3R)-2-amino-9-methoxy-3-(2,4,5-trifluorophenyl)-2,3-dihydro-1H-naphtho[2,1-b]pyran-8-carbonitrile'>9EL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zid OCA], [http://pdbe.org/5zid PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zid RCSB], [http://www.ebi.ac.uk/pdbsum/5zid PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zid ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DPP4_HUMAN DPP4_HUMAN]] Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.<ref>PMID:10951221</ref> <ref>PMID:17549790</ref> <ref>PMID:10570924</ref> <ref>PMID:10900005</ref> <ref>PMID:11772392</ref> <ref>PMID:14691230</ref> <ref>PMID:16651416</ref> <ref>PMID:17287217</ref> <ref>PMID:18708048</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Dipeptidyl-peptidase IV]]
		+	[[Category: Large Structures]]
	[[Category: Li, H]]		[[Category: Li, H]]
	[[Category: Wu, F]]		[[Category: Wu, F]]
	[[Category: Zhu, L]]		[[Category: Zhu, L]]
		+	[[Category: Dpp-4]]
		+	[[Category: Hydrolase]]
		+	[[Category: Inhibitor complex]]

OCA at 13:27, 27 February 2019

OCA — Wed, 27 Feb 2019 13:27:40 GMT

←Older revision		Revision as of 13:27, 27 February 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5zid is ON HOLD	+	The entry 5zid is ON HOLD until Paper Publication

	Authors: Zhu, L., Li, H., Wu, F.		Authors: Zhu, L., Li, H., Wu, F.

OCA at 04:30, 4 April 2018

OCA — Wed, 04 Apr 2018 04:30:07 GMT

←Older revision		Revision as of 04:30, 4 April 2018
Line 3:		Line 3:
	The entry 5zid is ON HOLD		The entry 5zid is ON HOLD

-	Authors: ~~Lili~~, Z., ~~Honglin~~, L., ~~Fangshu~~, W.	+	Authors: Zhu, L., Li, H., Wu, F.

	Description: Crystal Structure of human DPP-IV in complex with HL2		Description: Crystal Structure of human DPP-IV in complex with HL2
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: ~~Fangshu~~, W]]	+	[[Category: Li, H]]
-	[[Category: ~~Honglin~~, L]]	+	[[Category: Wu, F]]
-	[[Category: ~~Lili~~, Z]]	+	[[Category: Zhu, L]]

OCA: Protected "5zid" [edit=sysop:move=sysop]

OCA — Wed, 21 Mar 2018 06:03:00 GMT

Protected "5zid" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:03, 21 March 2018

OCA: New page: '''Unreleased structure''' The entry 5zid is ON HOLD Authors: Lili, Z., Honglin, L., Fangshu, W. Description: Crystal Structure of human DPP-IV in complex with HL2 [[Category: Unreleas...

OCA — Wed, 21 Mar 2018 06:02:58 GMT

New page: '''Unreleased structure''' The entry 5zid is ON HOLD Authors: Lili, Z., Honglin, L., Fangshu, W. Description: Crystal Structure of human DPP-IV in complex with HL2 [[Category: Unreleas...

New page

'''Unreleased structure'''

The entry 5zid is ON HOLD

Authors: Lili, Z., Honglin, L., Fangshu, W.

Description: Crystal Structure of human DPP-IV in complex with HL2
[[Category: Unreleased Structures]]
[[Category: Fangshu, W]]
[[Category: Honglin, L]]
[[Category: Lili, Z]]