5zje - Revision history

OCA at 08:57, 22 November 2023

OCA — Wed, 22 Nov 2023 08:57:38 GMT

←Older revision		Revision as of 08:57, 22 November 2023
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	<StructureSection load='5zje' size='340' side='right'caption='[[5zje]], [[Resolution\|resolution]] 2.93Å' scene=''>		<StructureSection load='5zje' size='340' side='right'caption='[[5zje]], [[Resolution\|resolution]] 2.93Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5zje]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZJE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ZJE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5zje]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZJE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZJE FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.929Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">LDHA, PIG19 ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>~~[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27]~~ </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zje FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zje OCA], [https://pdbe.org/5zje PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zje RCSB], [https://www.ebi.ac.uk/pdbsum/5zje PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zje ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5zje FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zje OCA], [~~http~~://pdbe.org/5zje PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5zje RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5zje PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5zje ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/LDHA_HUMAN LDHA_HUMAN]] Defects in LDHA are the cause of glycogen storage disease type 11 (GSD11) [MIM:[~~http~~://omim.org/entry/612933 612933]]. A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.<ref>PMID:2334430</ref>	+	[https://www.uniprot.org/uniprot/LDHA_HUMAN LDHA_HUMAN] Defects in LDHA are the cause of glycogen storage disease type 11 (GSD11) [MIM:[https://omim.org/entry/612933 612933]. A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.<ref>PMID:2334430</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/LDHA_HUMAN LDHA_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: L-lactate dehydrogenase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Han~~, C W~~]]	+	[[Category: Han CW]]
-	[[Category: Jang~~, S B]]~~	+	[[Category: Jang SB]]
-	~~[[Category: Ldha wt]]~~	+
-	~~[[Category: Malonate]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 17:06, 20 November 2019

OCA — Wed, 20 Nov 2019 17:06:45 GMT

←Older revision		Revision as of 17:06, 20 November 2019
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	<StructureSection load='5zje' size='340' side='right'caption='[[5zje]], [[Resolution\|resolution]] 2.93Å' scene=''>		<StructureSection load='5zje' size='340' side='right'caption='[[5zje]], [[Resolution\|resolution]] 2.93Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5zje]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZJE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZJE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5zje]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZJE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZJE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LDHA, PIG19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zje FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zje OCA], [http://pdbe.org/5zje PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zje RCSB], [http://www.ebi.ac.uk/pdbsum/5zje PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zje ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zje FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zje OCA], [http://pdbe.org/5zje PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zje RCSB], [http://www.ebi.ac.uk/pdbsum/5zje PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zje ProSAT]</span></td></tr>
Line 10:		Line 11:
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/LDHA_HUMAN LDHA_HUMAN]] Defects in LDHA are the cause of glycogen storage disease type 11 (GSD11) [MIM:[http://omim.org/entry/612933 612933]]. A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.<ref>PMID:2334430</ref>		[[http://www.uniprot.org/uniprot/LDHA_HUMAN LDHA_HUMAN]] Defects in LDHA are the cause of glycogen storage disease type 11 (GSD11) [MIM:[http://omim.org/entry/612933 612933]]. A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.<ref>PMID:2334430</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Lactate dehydrogenase A (LDHA) is an important enzyme responsible for cancer growth and energy metabolism in various cancers via the aerobic glycolytic pathway. Here, we report that machilin A (MA), which acts as a competitive inhibitor by blocking the nicotinamide adenine dinucleotide (NAD) binding site of LDHA, suppresses growth of cancer cells and lactate production in various cancer cell types, including colon, breast, lung, and liver cancers. Furthermore, MA markedly decreased LDHA activity, lactate production, and intracellular adenosine triphosphate (ATP) levels induced by hypoxia-induced LDHA expression in cancer cells, and significantly inhibited colony formation, leading to reduced cancer cell survival. In mouse models inoculated with murine Lewis lung carcinoma, MA significantly suppressed tumor growth as observed by a reduction of tumor volume and weight; resulting from the inhibition of LDHA activity. Subsequently, the suppression of tumor-derived lactic acid in MA-treated cancer cells resulted in decrease of neovascularization through the regulation of alternatively activated macrophages (M2) polarization in macrophages. Taken together, we suggest that the reduction of lactate by MA in cancer cells directly results in a suppression of cancer cell growth. Furthermore, macrophage polarization and activation of endothelial cells for angiogenesis were indirectly regulated preventing lactate production in MA-treated cancer cells.
		+
		+	Machilin A Inhibits Tumor Growth and Macrophage M2 Polarization Through the Reduction of Lactic Acid.,Chung TW, Kim EY, Han CW, Park SY, Jeong MS, Yoon D, Choi HJ, Jin L, Park MJ, Kwon YJ, Lee H, Kim KJ, Park KH, Kim S, Jang SB, Ha KT Cancers (Basel). 2019 Jul 9;11(7). pii: cancers11070963. doi:, 10.3390/cancers11070963. PMID:31324019<ref>PMID:31324019</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5zje" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Lactate dehydrogenase 3D structures\|Lactate dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: L-lactate dehydrogenase]]		[[Category: L-lactate dehydrogenase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 06:04, 24 July 2019

OCA — Wed, 24 Jul 2019 06:04:51 GMT

←Older revision		Revision as of 06:04, 24 July 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5zje is ~~ON HOLD until Sep 20 2020~~	+	==LDHA-mla==
-		+	<StructureSection load='5zje' size='340' side='right'caption='[[5zje]], [[Resolution\|resolution]] 2.93Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5zje]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZJE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZJE FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zje FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zje OCA], [http://pdbe.org/5zje PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zje RCSB], [http://www.ebi.ac.uk/pdbsum/5zje PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zje ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/LDHA_HUMAN LDHA_HUMAN]] Defects in LDHA are the cause of glycogen storage disease type 11 (GSD11) [MIM:[http://omim.org/entry/612933 612933]]. A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.<ref>PMID:2334430</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: L-lactate dehydrogenase]]
		+	[[Category: Large Structures]]
		+	[[Category: Han, C W]]
		+	[[Category: Jang, S B]]
		+	[[Category: Ldha wt]]
		+	[[Category: Malonate]]
		+	[[Category: Oxidoreductase]]

OCA at 20:52, 5 June 2019

OCA — Wed, 05 Jun 2019 20:52:37 GMT

←Older revision		Revision as of 20:52, 5 June 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5zje is ON HOLD	+	The entry 5zje is ON HOLD until Sep 20 2020

	Authors:		Authors:

OCA at 03:47, 22 May 2019

OCA — Wed, 22 May 2019 03:47:45 GMT

←Older revision		Revision as of 03:47, 22 May 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5zje is ON HOLD ~~until Paper Publication~~	+	The entry 5zje is ON HOLD

	Authors:		Authors:

OCA at 05:33, 21 May 2019

OCA — Tue, 21 May 2019 05:33:39 GMT

←Older revision		Revision as of 05:33, 21 May 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5zje is ON HOLD	+	The entry 5zje is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5zje" [edit=sysop:move=sysop]

OCA — Wed, 28 Mar 2018 05:11:31 GMT

Protected "5zje" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:11, 28 March 2018

OCA: New page: '''Unreleased structure''' The entry 5zje is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 28 Mar 2018 05:11:30 GMT

New page: '''Unreleased structure''' The entry 5zje is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5zje is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]