OCA at 06:48, 3 April 2019

OCA — Wed, 03 Apr 2019 06:48:32 GMT

←Older revision		Revision as of 06:48, 3 April 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5zjw is ~~ON HOLD until Paper Publication~~	+	==Crystal Structure of PAK4 in complex with inhibitor CZg353==
-		+	<StructureSection load='5zjw' size='340' side='right'caption='[[5zjw]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~Authors~~: ~~Zhao~~, F., Li, H.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5zjw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZJW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZJW FirstGlance]. <br>
-	~~Description~~: ~~Crystal Structure~~ of ~~PAK4~~ in ~~complex with inhibitor CZg353~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9EO:(3Z)-N-[(1S)-2-hydroxy-1-phenylethyl]-3-[(1H-imidazol-2-yl)(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-5-carboxamide'>9EO</scene>, <scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zjw OCA], [http://pdbe.org/5zjw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zjw RCSB], [http://www.ebi.ac.uk/pdbsum/5zjw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zjw ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PAK4_HUMAN PAK4_HUMAN]] Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN.<ref>PMID:11278822</ref> <ref>PMID:11313478</ref> <ref>PMID:14560027</ref> <ref>PMID:15660133</ref> <ref>PMID:20507994</ref> <ref>PMID:20805321</ref> <ref>PMID:20631255</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Li, H]]		[[Category: Li, H]]
	[[Category: Zhao, F]]		[[Category: Zhao, F]]
		+	[[Category: Atp binding pocket]]
		+	[[Category: Transferase]]

OCA at 05:46, 23 May 2018

OCA — Wed, 23 May 2018 05:46:49 GMT

←Older revision		Revision as of 05:46, 23 May 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5zjw is ON HOLD	+	The entry 5zjw is ON HOLD until Paper Publication

	Authors: Zhao, F., Li, H.		Authors: Zhao, F., Li, H.

OCA: Protected "5zjw" [edit=sysop:move=sysop]

OCA — Wed, 28 Mar 2018 05:13:05 GMT

Protected "5zjw" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:13, 28 March 2018

OCA: New page: '''Unreleased structure''' The entry 5zjw is ON HOLD Authors: Zhao, F., Li, H. Description: Crystal Structure of PAK4 in complex with inhibitor CZg353 [[Category: Unreleased Structures...

OCA — Wed, 28 Mar 2018 05:13:04 GMT

New page: '''Unreleased structure''' The entry 5zjw is ON HOLD Authors: Zhao, F., Li, H. Description: Crystal Structure of PAK4 in complex with inhibitor CZg353 [[Category: Unreleased Structures...

New page

'''Unreleased structure'''

The entry 5zjw is ON HOLD

Authors: Zhao, F., Li, H.

Description: Crystal Structure of PAK4 in complex with inhibitor CZg353
[[Category: Unreleased Structures]]
[[Category: Li, H]]
[[Category: Zhao, F]]

5zjw - Revision history

OCA at 06:48, 3 April 2019

OCA at 05:46, 23 May 2018

OCA: Protected "5zjw" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 5zjw is ON HOLD Authors: Zhao, F., Li, H. Description: Crystal Structure of PAK4 in complex with inhibitor CZg353 [[Category: Unreleased Structures...