5zle - Revision history

OCA at 08:59, 22 November 2023

OCA — Wed, 22 Nov 2023 08:59:31 GMT

←Older revision		Revision as of 08:59, 22 November 2023
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	<StructureSection load='5zle' size='340' side='right'caption='[[5zle]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='5zle' size='340' side='right'caption='[[5zle]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5zle]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZLE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ZLE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5zle]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZLE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZLE FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~CYBRD1, DCYTB, FRRS3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5zle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zle OCA], [~~http~~://pdbe.org/5zle PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5zle RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5zle PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5zle ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zle OCA], [https://pdbe.org/5zle PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zle RCSB], [https://www.ebi.ac.uk/pdbsum/5zle PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zle ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CYBR1_HUMAN CYBR1_HUMAN]] Ferric-chelate reductase that reduces Fe(3+) to Fe(2+). Present at the brush border of duodenal enterocytes where it probably reduces dietary Fe(3+) thereby facilitating its transport into the mucosal cells. Uses ascorbate as electron donor. May be involved in extracellular ascorbate recycling in erythrocyte membranes. May also act as a ferrireductase in airway epithelial cells.<ref>PMID:16521311</ref> <ref>PMID:16521312</ref> <ref>PMID:17068337</ref> <ref>PMID:19673882</ref>	+	[https://www.uniprot.org/uniprot/CYBR1_HUMAN CYBR1_HUMAN] Ferric-chelate reductase that reduces Fe(3+) to Fe(2+). Present at the brush border of duodenal enterocytes where it probably reduces dietary Fe(3+) thereby facilitating its transport into the mucosal cells. Uses ascorbate as electron donor. May be involved in extracellular ascorbate recycling in erythrocyte membranes. May also act as a ferrireductase in airway epithelial cells.<ref>PMID:16521311</ref> <ref>PMID:16521312</ref> <ref>PMID:17068337</ref> <ref>PMID:19673882</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ganasen, M]]	+	[[Category: Ganasen M]]
-	[[Category: Mauk~~, G A~~]]	+	[[Category: Mauk GA]]
-	[[Category: Sawai, H]]	+	[[Category: Sawai H]]
-	[[Category: Shiro, Y]]	+	[[Category: Shiro Y]]
-	[[Category: Sugimoto, H]]	+	[[Category: Sugimoto H]]
-	[[Category: Togashi, H]]	+	[[Category: Togashi H]]
-	~~[[Category: Electron transport]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 15:50, 28 August 2019

OCA — Wed, 28 Aug 2019 15:50:37 GMT

←Older revision		Revision as of 15:50, 28 August 2019
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	==Human duodenal cytochrome b (Dcytb) in substrate free form==		==Human duodenal cytochrome b (Dcytb) in substrate free form==
-	<StructureSection load='5zle' size='340' side='right' caption='[[5zle]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='5zle' size='340' side='right'caption='[[5zle]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5zle]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZLE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZLE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5zle]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZLE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZLE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYBRD1, DCYTB, FRRS3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zle OCA], [http://pdbe.org/5zle PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zle RCSB], [http://www.ebi.ac.uk/pdbsum/5zle PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zle ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zle OCA], [http://pdbe.org/5zle PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zle RCSB], [http://www.ebi.ac.uk/pdbsum/5zle PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zle ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Ganasen, M]]		[[Category: Ganasen, M]]
	[[Category: Mauk, G A]]		[[Category: Mauk, G A]]

OCA at 06:46, 31 October 2018

OCA — Wed, 31 Oct 2018 06:46:13 GMT

←Older revision		Revision as of 06:46, 31 October 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 5zle is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Human duodenal cytochrome b (Dcytb) in substrate free form==
		+	<StructureSection load='5zle' size='340' side='right' caption='[[5zle]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5zle]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZLE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZLE FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zle OCA], [http://pdbe.org/5zle PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zle RCSB], [http://www.ebi.ac.uk/pdbsum/5zle PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zle ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CYBR1_HUMAN CYBR1_HUMAN]] Ferric-chelate reductase that reduces Fe(3+) to Fe(2+). Present at the brush border of duodenal enterocytes where it probably reduces dietary Fe(3+) thereby facilitating its transport into the mucosal cells. Uses ascorbate as electron donor. May be involved in extracellular ascorbate recycling in erythrocyte membranes. May also act as a ferrireductase in airway epithelial cells.<ref>PMID:16521311</ref> <ref>PMID:16521312</ref> <ref>PMID:17068337</ref> <ref>PMID:19673882</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Dietary iron absorption is regulated by duodenal cytochrome b (Dcytb), an integral membrane protein that catalyzes reduction of nonheme Fe(3+) by electron transfer from ascorbate across the membrane. This step is essential to enable iron uptake by the divalent metal transporter. Here we report the crystallographic structures of human Dcytb and its complex with ascorbate and Zn(2+). Each monomer of the homodimeric protein possesses cytoplasmic and apical heme groups, as well as cytoplasmic and apical ascorbate-binding sites located adjacent to each heme. Zn(2+) coordinates to two hydroxyl groups of the apical ascorbate and to a histidine residue. Biochemical analysis indicates that Fe(3+) competes with Zn(2+) for this binding site. These results provide a structural basis for the mechanism by which Fe(3+) uptake is promoted by reducing agents and should facilitate structure-based development of improved agents for absorption of orally administered iron.

-	~~Authors~~:	+	Structural basis for promotion of duodenal iron absorption by enteric ferric reductase with ascorbate.,Ganasen M, Togashi H, Takeda H, Asakura H, Tosha T, Yamashita K, Hirata K, Nariai Y, Urano T, Yuan X, Hamza I, Mauk AG, Shiro Y, Sugimoto H, Sawai H Commun Biol. 2018 Aug 17;1:120. doi: 10.1038/s42003-018-0121-8. eCollection 2018. PMID:30272000<ref>PMID:30272000</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5zle" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Ganasen, M]]
		+	[[Category: Mauk, G A]]
		+	[[Category: Sawai, H]]
		+	[[Category: Shiro, Y]]
		+	[[Category: Sugimoto, H]]
		+	[[Category: Togashi, H]]
		+	[[Category: Electron transport]]
		+	[[Category: Oxidoreductase]]

OCA at 03:48, 16 May 2018

OCA — Wed, 16 May 2018 03:48:18 GMT

←Older revision		Revision as of 03:48, 16 May 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5zle is ON HOLD	+	The entry 5zle is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5zle" [edit=sysop:move=sysop]

OCA — Wed, 04 Apr 2018 04:34:07 GMT

Protected "5zle" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:34, 4 April 2018

OCA: New page: '''Unreleased structure''' The entry 5zle is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 04 Apr 2018 04:34:06 GMT

New page: '''Unreleased structure''' The entry 5zle is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5zle is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]