5zlz - Revision history

OCA at 09:00, 22 November 2023

OCA — Wed, 22 Nov 2023 09:00:25 GMT

←Older revision		Revision as of 09:00, 22 November 2023
Line 3:		Line 3:
	<StructureSection load='5zlz' size='340' side='right'caption='[[5zlz]], [[Resolution\|resolution]] 3.58Å' scene=''>		<StructureSection load='5zlz' size='340' side='right'caption='[[5zlz]], [[Resolution\|resolution]] 3.58Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5zlz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZLZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ZLZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5zlz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZLZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZLZ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=GOL:GLYCEROL'>GOL</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.581Å</td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>~~[http://en.wikipedia.org/wiki/T-plasminogen_activator T-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.68 3.4.21.68]~~ </~~span~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5zlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zlz OCA], [~~http~~://pdbe.org/5zlz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5zlz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5zlz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5zlz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zlz OCA], [https://pdbe.org/5zlz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zlz RCSB], [https://www.ebi.ac.uk/pdbsum/5zlz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zlz ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/PAI1_HUMAN PAI1_HUMAN]] Defects in SERPINE1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1D) [MIM:[~~http~~://omim.org/entry/613329 613329]]. It is a hematologic disorder characterized by increased bleeding after trauma, injury, or surgery. Affected females have menorrhagia. The bleeding defect is due to increased fibrinolysis of fibrin blood clots due to deficiency of plasminogen activator inhibitor-1, which inhibits tissue and urinary activators of plasminogen.<ref>PMID:9207454</ref> Note=High concentrations of SERPINE1 seem to contribute to the development of venous but not arterial occlusions. [[http://www.uniprot.org/uniprot/TPA_HUMAN TPA_HUMAN]] Note=Increased activity of TPA results in increased fibrinolysis of fibrin blood clots that is associated with excessive bleeding. Defective release of TPA results in hypofibrinolysis that can lead to thrombosis or embolism.	+	[https://www.uniprot.org/uniprot/PAI1_HUMAN PAI1_HUMAN] Defects in SERPINE1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1D) [MIM:[https://omim.org/entry/613329 613329]. It is a hematologic disorder characterized by increased bleeding after trauma, injury, or surgery. Affected females have menorrhagia. The bleeding defect is due to increased fibrinolysis of fibrin blood clots due to deficiency of plasminogen activator inhibitor-1, which inhibits tissue and urinary activators of plasminogen.<ref>PMID:9207454</ref> Note=High concentrations of SERPINE1 seem to contribute to the development of venous but not arterial occlusions.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PAI1_HUMAN PAI1_HUMAN]] Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.<ref>PMID:15853774</ref> [[~~http://www.uniprot.org/uniprot/TPA_HUMAN TPA_HUMAN~~]] Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration.	+	[https://www.uniprot.org/uniprot/PAI1_HUMAN PAI1_HUMAN] Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.<ref>PMID:15853774</ref>
		+
		+	==See Also==
		+	*[[Plasminogen activator\|Plasminogen activator]]
		+	*[[Plasminogen activator inhibitor\|Plasminogen activator inhibitor]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: T-plasminogen activator]]~~	+	[[Category: Huang M]]
-	[[Category: Huang, M]]	+	[[Category: Min L]]
-	[[Category: Min, L]]	+
-	~~[[Category: Fibrinolysis]]~~	+
-	~~[[Category: Hydrolase inhibitor-hydrolase complex]]~~	+
-	~~[[Category: Pai-1]]~~	+
-	~~[[Category: Paitrap2~~]]	+

OCA at 06:49, 3 April 2019

OCA — Wed, 03 Apr 2019 06:49:04 GMT

←Older revision		Revision as of 06:49, 3 April 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5zlz is ~~ON HOLD until Paper Publication~~	+	==Structure of tPA and PAI-1==
-		+	<StructureSection load='5zlz' size='340' side='right'caption='[[5zlz]], [[Resolution\|resolution]] 3.58Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5zlz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZLZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZLZ FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/T-plasminogen_activator T-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.68 3.4.21.68] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zlz OCA], [http://pdbe.org/5zlz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zlz RCSB], [http://www.ebi.ac.uk/pdbsum/5zlz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zlz ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/PAI1_HUMAN PAI1_HUMAN]] Defects in SERPINE1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1D) [MIM:[http://omim.org/entry/613329 613329]]. It is a hematologic disorder characterized by increased bleeding after trauma, injury, or surgery. Affected females have menorrhagia. The bleeding defect is due to increased fibrinolysis of fibrin blood clots due to deficiency of plasminogen activator inhibitor-1, which inhibits tissue and urinary activators of plasminogen.<ref>PMID:9207454</ref> Note=High concentrations of SERPINE1 seem to contribute to the development of venous but not arterial occlusions. [[http://www.uniprot.org/uniprot/TPA_HUMAN TPA_HUMAN]] Note=Increased activity of TPA results in increased fibrinolysis of fibrin blood clots that is associated with excessive bleeding. Defective release of TPA results in hypofibrinolysis that can lead to thrombosis or embolism.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PAI1_HUMAN PAI1_HUMAN]] Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.<ref>PMID:15853774</ref> [[http://www.uniprot.org/uniprot/TPA_HUMAN TPA_HUMAN]] Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration.
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: T-plasminogen activator]]
		+	[[Category: Huang, M]]
		+	[[Category: Min, L]]
		+	[[Category: Fibrinolysis]]
		+	[[Category: Hydrolase inhibitor-hydrolase complex]]
		+	[[Category: Pai-1]]
		+	[[Category: Paitrap2]]

OCA at 04:03, 18 April 2018

OCA — Wed, 18 Apr 2018 04:03:04 GMT

←Older revision		Revision as of 04:03, 18 April 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5zlz is ON HOLD	+	The entry 5zlz is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5zlz" [edit=sysop:move=sysop]

OCA — Wed, 11 Apr 2018 12:19:50 GMT

Protected "5zlz" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:19, 11 April 2018

OCA: New page: '''Unreleased structure''' The entry 5zlz is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 11 Apr 2018 12:19:49 GMT

New page: '''Unreleased structure''' The entry 5zlz is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5zlz is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]