5zm2 - Revision history

OCA at 09:00, 22 November 2023

OCA — Wed, 22 Nov 2023 09:00:34 GMT

←Older revision		Revision as of 09:00, 22 November 2023
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	==Fe(II)/(alpha)ketoglutarate-dependent dioxygenase AndA==		==Fe(II)/(alpha)ketoglutarate-dependent dioxygenase AndA==
-	<StructureSection load='5zm2' size='340' side='right' caption='[[5zm2]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='5zm2' size='340' side='right'caption='[[5zm2]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5zm2]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_16819 Atcc 16819~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZM2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ZM2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5zm2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_stellatus Aspergillus stellatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZM2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZM2 FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~andA (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=~~5&~~id=1549217 ATCC 16819])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5zm2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zm2 OCA], [~~http~~://pdbe.org/5zm2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5zm2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5zm2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5zm2 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zm2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zm2 OCA], [https://pdbe.org/5zm2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zm2 RCSB], [https://www.ebi.ac.uk/pdbsum/5zm2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zm2 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ANDA_EMEVA ANDA_EMEVA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 5zm2" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5zm2" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Dioxygenase 3D structures\|Dioxygenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atcc 16819~~]]	+	[[Category: Aspergillus stellatus]]
-	[[Category: ~~Nakashima, Y~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Senda, T~~]]	+	[[Category: Nakashima Y]]
-	[[Category: ~~Oxidoreductase~~]]	+	[[Category: Senda T]]

OCA at 07:53, 29 August 2018

OCA — Wed, 29 Aug 2018 07:53:41 GMT

←Older revision		Revision as of 07:53, 29 August 2018
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	<StructureSection load='5zm2' size='340' side='right' caption='[[5zm2]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='5zm2' size='340' side='right' caption='[[5zm2]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5zm2]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZM2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZM2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5zm2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_16819 Atcc 16819]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZM2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZM2 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zm2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zm2 OCA], [http://pdbe.org/5zm2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zm2 RCSB], [http://www.ebi.ac.uk/pdbsum/5zm2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zm2 ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">andA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1549217 ATCC 16819])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zm2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zm2 OCA], [http://pdbe.org/5zm2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zm2 RCSB], [http://www.ebi.ac.uk/pdbsum/5zm2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zm2 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 16819]]
	[[Category: Nakashima, Y]]		[[Category: Nakashima, Y]]
	[[Category: Senda, T]]		[[Category: Senda, T]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 07:32, 18 July 2018

OCA — Wed, 18 Jul 2018 07:32:05 GMT

←Older revision		Revision as of 07:32, 18 July 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 5zm2 is ~~ON HOLD until Apr 01 2020~~	+	==Fe(II)/(alpha)ketoglutarate-dependent dioxygenase AndA==
		+	<StructureSection load='5zm2' size='340' side='right' caption='[[5zm2]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5zm2]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZM2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZM2 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zm2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zm2 OCA], [http://pdbe.org/5zm2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zm2 RCSB], [http://www.ebi.ac.uk/pdbsum/5zm2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zm2 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	AndA, an Fe(II)/alpha-ketoglutarate (alphaKG)-dependent enzyme, is the key enzyme that constructs the unique and congested bridged-ring system of anditomin (1), by catalyzing consecutive dehydrogenation and isomerization reactions. Although we previously characterized AndA to some extent, the means by which the enzyme facilitates this drastic structural reconstruction have remained elusive. In this study, we have solved three X-ray crystal structures of AndA, in its apo form and in the complexes with Fe(II), alphaKG, and two substrates. The crystal structures and mutational experiments identified several key amino acid residues important for the catalysis and provided insight into how AndA controls the reaction. Furthermore, computational calculations validated the proposed reaction mechanism for the bridged-ring formation and also revealed the requirement of a series of conformational changes during the transformation.

-	~~Authors~~:	+	Structural and Computational Bases for Dramatic Skeletal Rearrangement in Anditomin Biosynthesis.,Nakashima Y, Mitsuhashi T, Matsuda Y, Senda M, Sato H, Yamazaki M, Uchiyama M, Senda T, Abe I J Am Chem Soc. 2018 Jul 4. doi: 10.1021/jacs.8b06084. PMID:29972643<ref>PMID:29972643</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5zm2" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Nakashima, Y]]
		+	[[Category: Senda, T]]
		+	[[Category: Oxidoreductase]]

OCA at 03:49, 25 April 2018

OCA — Wed, 25 Apr 2018 03:49:35 GMT

←Older revision		Revision as of 03:49, 25 April 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5zm2 is ON HOLD	+	The entry 5zm2 is ON HOLD until Apr 01 2020

	Authors:		Authors:

OCA: Protected "5zm2" [edit=sysop:move=sysop]

OCA — Wed, 11 Apr 2018 12:20:14 GMT

Protected "5zm2" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:20, 11 April 2018

OCA: New page: '''Unreleased structure''' The entry 5zm2 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 11 Apr 2018 12:20:13 GMT

New page: '''Unreleased structure''' The entry 5zm2 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5zm2 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]