5zml - Revision history

OCA at 09:01, 22 November 2023

OCA — Wed, 22 Nov 2023 09:01:19 GMT

←Older revision		Revision as of 09:01, 22 November 2023
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	<StructureSection load='5zml' size='340' side='right'caption='[[5zml]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='5zml' size='340' side='right'caption='[[5zml]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5zml]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZML OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ZML FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5zml]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZML OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZML FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=EDO:1,2~~-~~ETHANEDIOL'>EDO</scene>~~, ~~<scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">EIF4E, EIF4EL1, EIF4F ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zml OCA], [https://pdbe.org/5zml PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zml RCSB], [https://www.ebi.ac.uk/pdbsum/5zml PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zml ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5zml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zml OCA], [~~http~~://pdbe.org/5zml PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5zml RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5zml PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5zml ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/IF4E_HUMAN IF4E_HUMAN]] Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:16271312</ref>	+	[https://www.uniprot.org/uniprot/IF4E_HUMAN IF4E_HUMAN] Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:16271312</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 5zml" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5zml" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Eukaryotic initiation factor 3D structures\|Eukaryotic initiation factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Auvin, S]]	+	[[Category: Auvin S]]
-	[[Category: Bashir, T]]	+	[[Category: Bashir T]]
-	[[Category: Brown~~, C J~~]]	+	[[Category: Brown CJ]]
-	[[Category: Frosi, Y]]	+	[[Category: Frosi Y]]
-	[[Category: Lama, D]]	+	[[Category: Lama D]]
-	[[Category: Lane~~, D P~~]]	+	[[Category: Lane DP]]
-	[[Category: Liberator, A]]	+	[[Category: Liberator A]]
-	[[Category: Nakhle, J]]	+	[[Category: Nakhle J]]
-	[[Category: Tsomia, N]]	+	[[Category: Tsomia N]]
-	[[Category: Verma~~, C S~~]]	+	[[Category: Verma CS]]
-	[[Category: Yano, J]]	+	[[Category: Yano J]]
-	~~[[Category: Cap dependent translation]]~~	+
-	~~[[Category: Rna binding protein~~]]	+

OCA at 08:07, 3 April 2019

OCA — Wed, 03 Apr 2019 08:07:10 GMT

←Older revision		Revision as of 08:07, 3 April 2019
Line 1:		Line 1:

	==Stapled-peptides tailored against initiation of translation==		==Stapled-peptides tailored against initiation of translation==
-	<StructureSection load='5zml' size='340' side='right' caption='[[5zml]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='5zml' size='340' side='right'caption='[[5zml]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5zml]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZML OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZML FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5zml]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZML OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZML FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EIF4E, EIF4EL1, EIF4F ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zml OCA], [http://pdbe.org/5zml PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zml RCSB], [http://www.ebi.ac.uk/pdbsum/5zml PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zml ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zml OCA], [http://pdbe.org/5zml PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zml RCSB], [http://www.ebi.ac.uk/pdbsum/5zml PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zml ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/IF4E_HUMAN IF4E_HUMAN]] Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:16271312</ref>		[[http://www.uniprot.org/uniprot/IF4E_HUMAN IF4E_HUMAN]] Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:16271312</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Stapled-peptides have emerged as an exciting class of molecules which can modulate protein-protein interactions. We have used a structure-guided approach to rationally develop a set of hydrocarbon stapled-peptides with high binding affinities and residence times against the oncogenic eukaryotic translation initiation factor 4E (eIF4E) protein. Crystal structures of these peptides in complex with eIF4E show that they form specific interactions with a region on the protein-binding interface of eIF4E which is distinct from the other well-established canonical interactions. This recognition element is a major molecular determinant underlying the improved binding kinetics of these peptides with eIF4E. The interactions were further exploited by designing features in the peptides to attenuate disorder and increase helicity which collectively resulted in the generation of a distinct class of hydrocarbon stapled-peptides targeting eIF4E. This study details new insights into the molecular basis of stapled-peptide: eIF4E interactions and their exploitation to enhance promising lead molecules for the development of stapled-peptide compounds for oncology.
		+
		+	Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein.,Lama D, Liberatore AM, Frosi Y, Nakhle J, Tsomaia N, Bashir T, Lane DP, Brown CJ, Verma CS, Auvin S Chem Sci. 2019 Jan 7;10(8):2489-2500. doi: 10.1039/c8sc03759k. eCollection 2019, Feb 28. PMID:30881679<ref>PMID:30881679</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5zml" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Auvin, S]]		[[Category: Auvin, S]]
	[[Category: Bashir, T]]		[[Category: Bashir, T]]

OCA at 06:35, 21 February 2019

OCA — Thu, 21 Feb 2019 06:35:47 GMT

←Older revision		Revision as of 06:35, 21 February 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5zml ~~is ON HOLD until Paper Publication~~	+	==Stapled-peptides tailored against initiation of translation==
-		+	<StructureSection load='5zml' size='340' side='right' caption='[[5zml]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~Authors~~: ~~Lama, D~~.~~, Liberator, A~~.~~, Frosi, Y~~.~~, Nakhle, J~~.~~, Tsomia, N~~.~~, Bashir, T~~., ~~Lane~~, D.P., ~~Brown, C~~.J., ~~Verma~~, C.S., ~~Auvin, S~~., ~~Yano, J~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5zml]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZML OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZML FirstGlance]. <br>
-	~~Description: Stapled-peptides tailored against initiation of translation~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures]]~~	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene></td></tr>
-	~~[[Category: Brown, C~~.J]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zml OCA], [http://pdbe.org/5zml PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zml RCSB], [http://www.ebi.ac.uk/pdbsum/5zml PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zml ProSAT]</span></td></tr>
-	[[Category: ~~Tsomia~~, N]]	+	</table>
-	[[Category: ~~Nakhle~~, J]]	+	== Function ==
-	[[Category: ~~Yano~~, J]]	+	[[http://www.uniprot.org/uniprot/IF4E_HUMAN IF4E_HUMAN]] Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:16271312</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Auvin, S]]
		+	[[Category: Bashir, T]]
		+	[[Category: Brown, C J]]
	[[Category: Frosi, Y]]		[[Category: Frosi, Y]]
-	[[Category: Verma, C.S]]
	[[Category: Lama, D]]		[[Category: Lama, D]]
		+	[[Category: Lane, D P]]
	[[Category: Liberator, A]]		[[Category: Liberator, A]]
-	[[Category: ~~Auvin~~, S]]	+	[[Category: Nakhle, J]]
-	[[Category: ~~Bashir~~, T]]	+	[[Category: Tsomia, N]]
-	[[Category: ~~Lane~~, ~~D.P~~]]	+	[[Category: Verma, C S]]
		+	[[Category: Yano, J]]
		+	[[Category: Cap dependent translation]]
		+	[[Category: Rna binding protein]]

OCA at 04:06, 6 June 2018

OCA — Wed, 06 Jun 2018 04:06:29 GMT

←Older revision		Revision as of 04:06, 6 June 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5zml is ON HOLD	+	The entry 5zml is ON HOLD until Paper Publication

-	Authors: Lama, D., Liberator, A., Frosi, Y., Nakhle, J., Tsomia, N., Bashir, T., Lane, D.P., Brown, C.J., Verma, C.S., Auvin, S.	+	Authors: Lama, D., Liberator, A., Frosi, Y., Nakhle, J., Tsomia, N., Bashir, T., Lane, D.P., Brown, C.J., Verma, C.S., Auvin, S., Yano, J.

	Description: Stapled-peptides tailored against initiation of translation		Description: Stapled-peptides tailored against initiation of translation
Line 10:		Line 10:
	[[Category: Tsomia, N]]		[[Category: Tsomia, N]]
	[[Category: Nakhle, J]]		[[Category: Nakhle, J]]
		+	[[Category: Yano, J]]
	[[Category: Frosi, Y]]		[[Category: Frosi, Y]]
	[[Category: Verma, C.S]]		[[Category: Verma, C.S]]

OCA: Protected "5zml" [edit=sysop:move=sysop]

OCA — Wed, 11 Apr 2018 12:21:53 GMT

Protected "5zml" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:21, 11 April 2018

OCA: New page: '''Unreleased structure''' The entry 5zml is ON HOLD Authors: Lama, D., Liberator, A., Frosi, Y., Nakhle, J., Tsomia, N., Bashir, T., Lane, D.P., Brown, C.J., Verma, C.S., Auvin, S. De...

OCA — Wed, 11 Apr 2018 12:21:52 GMT

New page: '''Unreleased structure''' The entry 5zml is ON HOLD Authors: Lama, D., Liberator, A., Frosi, Y., Nakhle, J., Tsomia, N., Bashir, T., Lane, D.P., Brown, C.J., Verma, C.S., Auvin, S. De...

New page

'''Unreleased structure'''

The entry 5zml is ON HOLD

Authors: Lama, D., Liberator, A., Frosi, Y., Nakhle, J., Tsomia, N., Bashir, T., Lane, D.P., Brown, C.J., Verma, C.S., Auvin, S.

Description: Stapled-peptides tailored against initiation of translation
[[Category: Unreleased Structures]]
[[Category: Brown, C.J]]
[[Category: Tsomia, N]]
[[Category: Nakhle, J]]
[[Category: Frosi, Y]]
[[Category: Verma, C.S]]
[[Category: Lama, D]]
[[Category: Liberator, A]]
[[Category: Auvin, S]]
[[Category: Bashir, T]]
[[Category: Lane, D.P]]