5zpu - Revision history

OCA at 09:03, 22 November 2023

OCA — Wed, 22 Nov 2023 09:03:26 GMT

←Older revision		Revision as of 09:03, 22 November 2023
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	<StructureSection load='5zpu' size='340' side='right'caption='[[5zpu]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='5zpu' size='340' side='right'caption='[[5zpu]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5zpu]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZPU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ZPU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5zpu]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZPU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZPU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=D29:(Z)-{[(3E)-4-{(R)-[3,5-bis(trifluoromethyl)phenyl]sulfinyl}but-3-en-1-yl]imino}methanethiol'>D29</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5zpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zpu OCA], [~~http~~://pdbe.org/5zpu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5zpu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5zpu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5zpu ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=D29:(Z)-{[(3E)-4-{(R)-[3,5-bis(trifluoromethyl)phenyl]sulfinyl}but-3-en-1-yl]imino}methanethiol'>D29</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zpu OCA], [https://pdbe.org/5zpu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zpu RCSB], [https://www.ebi.ac.uk/pdbsum/5zpu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zpu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/RAN_HUMAN RAN_HUMAN]] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> [[~~http://www.uniprot.org/uniprot/XPO1_YEAST XPO1_YEAST~~]] ~~Receptor for the leucine-rich nuclear export signal (NES).~~ [[~~http://www.uniprot.org/uniprot/YRB1_YEAST YRB1_YEAST~~]] ~~Important for the export of protein containing nuclear export signal (NES) out of the nucleus. Stimulates the GTPase activity of GSP1 and GSP2.~~	+	[https://www.uniprot.org/uniprot/RAN_HUMAN RAN_HUMAN] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref>
		+
		+	==See Also==
		+	*[[Exportin 3D structures\|Exportin 3D structures]]
		+	*[[GTP-binding protein 3D structures\|GTP-binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lei, Y~~]]	+	[[Category: Saccharomyces cerevisiae S288C]]
-	[[Category: ~~Sun, Q~~]]	+	[[Category: Lei Y]]
-	[[Category: ~~Activation]]~~	+	[[Category: Sun Q]]
-	~~[[Category: Complex]]~~	+
-	~~[[Category: Mutant]]~~	+
-	~~[[Category: Nuclear export]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 05:49, 17 April 2019

OCA — Wed, 17 Apr 2019 05:49:26 GMT

←Older revision		Revision as of 05:49, 17 April 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 5zpu is ~~ON HOLD until Apr 16 2020~~	+	==LFS829 in complex with CRM1-Ran-RanBP1==
-		+	<StructureSection load='5zpu' size='340' side='right'caption='[[5zpu]], [[Resolution\|resolution]] 2.60Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5zpu]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZPU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZPU FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=D29:(Z)-{[(3E)-4-{(R)-[3,5-bis(trifluoromethyl)phenyl]sulfinyl}but-3-en-1-yl]imino}methanethiol'>D29</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zpu OCA], [http://pdbe.org/5zpu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zpu RCSB], [http://www.ebi.ac.uk/pdbsum/5zpu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zpu ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RAN_HUMAN RAN_HUMAN]] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> [[http://www.uniprot.org/uniprot/XPO1_YEAST XPO1_YEAST]] Receptor for the leucine-rich nuclear export signal (NES). [[http://www.uniprot.org/uniprot/YRB1_YEAST YRB1_YEAST]] Important for the export of protein containing nuclear export signal (NES) out of the nucleus. Stimulates the GTPase activity of GSP1 and GSP2.
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Lei, Y]]
		+	[[Category: Sun, Q]]
		+	[[Category: Activation]]
		+	[[Category: Complex]]
		+	[[Category: Mutant]]
		+	[[Category: Nuclear export]]
		+	[[Category: Transport protein]]

OCA at 06:33, 2 May 2018

OCA — Wed, 02 May 2018 06:33:06 GMT

←Older revision		Revision as of 06:33, 2 May 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5zpu is ON HOLD	+	The entry 5zpu is ON HOLD until Apr 16 2020

	Authors:		Authors:

OCA: Protected "5zpu" [edit=sysop:move=sysop]

OCA — Wed, 25 Apr 2018 03:53:49 GMT

Protected "5zpu" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:53, 25 April 2018

OCA: New page: '''Unreleased structure''' The entry 5zpu is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 25 Apr 2018 03:53:48 GMT

New page: '''Unreleased structure''' The entry 5zpu is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5zpu is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]