5zpw - Revision history

OCA at 09:03, 22 November 2023

OCA — Wed, 22 Nov 2023 09:03:28 GMT

←Older revision		Revision as of 09:03, 22 November 2023
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	==Generation of a long-acting fusion inhibitor against HIV-1==		==Generation of a long-acting fusion inhibitor against HIV-1==
-	<StructureSection load='5zpw' size='340' side='right' caption='[[5zpw]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='5zpw' size='340' side='right'caption='[[5zpw]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5zpw]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZPW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ZPW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5zpw]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZPW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZPW FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non~~-~~Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.199Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5zpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zpw OCA], [~~http~~://pdbe.org/5zpw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5zpw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5zpw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5zpw ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zpw OCA], [https://pdbe.org/5zpw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zpw RCSB], [https://www.ebi.ac.uk/pdbsum/5zpw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zpw ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A1S6KGE5_9HIV1 A0A1S6KGE5_9HIV1]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 16:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5zpw" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5zpw" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Gp41 3D Structures\|Gp41 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Guo, Y~~]]	+	[[Category: Human immunodeficiency virus 1]]
-	[[Category: ~~Shi, X L~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Complex~~]]	+	[[Category: Synthetic construct]]
-	[[Category: ~~Inhibitor~~]]	+	[[Category: Guo Y]]
-	[[Category: ~~Virus]]~~	+	[[Category: Shi XL]]
-	~~[[Category: Virus like particle~~]]	+

OCA at 07:23, 6 March 2019

OCA — Wed, 06 Mar 2019 07:23:24 GMT

←Older revision		Revision as of 07:23, 6 March 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 5zpw ~~is ON HOLD~~ ~~until Paper~~ Publication	+	==Generation of a long-acting fusion inhibitor against HIV-1==
		+	<StructureSection load='5zpw' size='340' side='right' caption='[[5zpw]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5zpw]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZPW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZPW FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zpw OCA], [http://pdbe.org/5zpw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zpw RCSB], [http://www.ebi.ac.uk/pdbsum/5zpw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zpw ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	AIDS has evolved from a fatal infectious disease to a manageable chronic disease under the treatment of anti-AIDS medications. HIV fusion inhibitors with high activity, low side effects and strong selectivity are promising drugs against HIV. Only one fusion inhibitor is currently approved, thereby highly active long-acting fusion inhibitors need to be developed for long-term AIDS treatment. Here, we synthesised MT-SC22EK (a small HIV fusion inhibitor) derivatives containing 1-2 staples to improve its stability. Antiviral activity studies showed that MT-SC22EK-2 with two staples exhibited potent inhibitory activity against HIV-1 standard strains and Chinese epidemic strains, and at the same time, MT-SC22EK-2 presented strong anti-T20 resistance. Surprisingly, MT-SC22EK-2 possessed excellent protease stability with a half-life of 3665 min. MT-SC22EK-2 is a potential HIV fusion inhibitor considered as a long-acting anti-HIV drug candidate.

-	~~Authors~~:	+	Generation of a long-acting fusion inhibitor against HIV-1.,Guo Y, Zhou PP, Zhang SY, Fan XW, Dou YW, Shi XL Medchemcomm. 2018 Jun 6;9(7):1226-1231. doi: 10.1039/c8md00124c. eCollection 2018, Jul 1. PMID:30109011<ref>PMID:30109011</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5zpw" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Guo, Y]]
		+	[[Category: Shi, X L]]
		+	[[Category: Complex]]
		+	[[Category: Inhibitor]]
		+	[[Category: Virus]]
		+	[[Category: Virus like particle]]

OCA at 05:02, 12 December 2018

OCA — Wed, 12 Dec 2018 05:02:02 GMT

←Older revision		Revision as of 05:02, 12 December 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5zpw is ON HOLD	+	The entry 5zpw is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5zpw" [edit=sysop:move=sysop]

OCA — Wed, 25 Apr 2018 03:53:54 GMT

Protected "5zpw" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:53, 25 April 2018

OCA: New page: '''Unreleased structure''' The entry 5zpw is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 25 Apr 2018 03:53:53 GMT

New page: '''Unreleased structure''' The entry 5zpw is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5zpw is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]