5zu0 - Revision history

OCA at 12:44, 25 December 2019

OCA — Wed, 25 Dec 2019 12:44:06 GMT

←Older revision		Revision as of 12:44, 25 December 2019
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	==Proteobacterial origin of protein arginine methylation and regulation of Complex I assembly by MidA==		==Proteobacterial origin of protein arginine methylation and regulation of Complex I assembly by MidA==
-	<StructureSection load='5zu0' size='340' side='right' caption='[[5zu0]], [[Resolution\|resolution]] 2.76Å' scene=''>	+	<StructureSection load='5zu0' size='340' side='right'caption='[[5zu0]], [[Resolution\|resolution]] 2.76Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5zu0]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Atcc_11735 Atcc 11735~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZU0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZU0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5zu0]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Dicdi Dicdi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZU0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZU0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ztz\|5ztz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ztz\|5ztz]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">midA, DDB_G0282615 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=44689 ~~ATCC 11735~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">midA, DDB_G0282615 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=44689 DICDI])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Type_II_protein_arginine_methyltransferase Type II protein arginine methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.320 2.1.1.320] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Type_II_protein_arginine_methyltransferase Type II protein arginine methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.320 2.1.1.320] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zu0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zu0 OCA], [http://pdbe.org/5zu0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zu0 RCSB], [http://www.ebi.ac.uk/pdbsum/5zu0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zu0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zu0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zu0 OCA], [http://pdbe.org/5zu0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zu0 RCSB], [http://www.ebi.ac.uk/pdbsum/5zu0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zu0 ProSAT]</span></td></tr>
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	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/NDUF7_DICDI NDUF7_DICDI]] Involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) (PubMed:16507593, PubMed:20406883). Acts as an arginine methyltransferase and probably acts by mediating arginine methylation of ndufs2 (By similarity).[UniProtKB:Q7L592]<ref>PMID:16507593</ref> <ref>PMID:20406883</ref>		[[http://www.uniprot.org/uniprot/NDUF7_DICDI NDUF7_DICDI]] Involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) (PubMed:16507593, PubMed:20406883). Acts as an arginine methyltransferase and probably acts by mediating arginine methylation of ndufs2 (By similarity).[UniProtKB:Q7L592]<ref>PMID:16507593</ref> <ref>PMID:20406883</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The human protein arginine methyltransferase NDUFAF7 controls the assembly of the approximately 1-MDa mitochondrial complex I (CI; the NADH ubiquinone oxidoreductase) by methylating its subunit NDUFS2. We determined crystal structures of MidA, the Dictyostelium ortholog of NDUFAF7. The MidA catalytic core domain resembles other eukaryotic methyltransferases. However, three large core loops assemble into a regulatory domain that is likely to control ligand selection. Binding of MidA to NDUFS2 is weakened by methylation, suggesting a mechanism for methylation-controlled substrate release. Structural and bioinformatic analyses support that MidA and NDUFAF7 and their role in CI assembly are conserved from bacteria to humans, implying that protein methylation already existed in proteobacteria. In vivo studies confirmed the critical role of the MidA methyltransferase activity for CI assembly, growth, and phototaxis of Dictyostelium. Collectively, our data elucidate the origin of protein arginine methylation and its use by MidA/NDUFAF7 to regulate CI assembly.
		+
		+	Proteobacterial Origin of Protein Arginine Methylation and Regulation of Complex I Assembly by MidA.,Shahul Hameed UF, Sanislav O, Lay ST, Annesley SJ, Jobichen C, Fisher PR, Swaminathan K, Arold ST Cell Rep. 2018 Aug 21;24(8):1996-2004. doi: 10.1016/j.celrep.2018.07.075. PMID:30134162<ref>PMID:30134162</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5zu0" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atcc 11735~~]]	+	[[Category: Dicdi]]
		+	[[Category: Large Structures]]
	[[Category: Type II protein arginine methyltransferase]]		[[Category: Type II protein arginine methyltransferase]]
	[[Category: Arold, S T]]		[[Category: Arold, S T]]

OCA at 07:54, 29 August 2018

OCA — Wed, 29 Aug 2018 07:54:08 GMT

←Older revision		Revision as of 07:54, 29 August 2018
Line 3:		Line 3:
	<StructureSection load='5zu0' size='340' side='right' caption='[[5zu0]], [[Resolution\|resolution]] 2.76Å' scene=''>		<StructureSection load='5zu0' size='340' side='right' caption='[[5zu0]], [[Resolution\|resolution]] 2.76Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5zu0]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZU0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZU0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5zu0]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_11735 Atcc 11735]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZU0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZU0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ztz\|5ztz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ztz\|5ztz]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">midA, DDB_G0282615 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=44689 ATCC 11735])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Type_II_protein_arginine_methyltransferase Type II protein arginine methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.320 2.1.1.320] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Type_II_protein_arginine_methyltransferase Type II protein arginine methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.320 2.1.1.320] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zu0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zu0 OCA], [http://pdbe.org/5zu0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zu0 RCSB], [http://www.ebi.ac.uk/pdbsum/5zu0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zu0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zu0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zu0 OCA], [http://pdbe.org/5zu0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zu0 RCSB], [http://www.ebi.ac.uk/pdbsum/5zu0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zu0 ProSAT]</span></td></tr>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 11735]]
	[[Category: Type II protein arginine methyltransferase]]		[[Category: Type II protein arginine methyltransferase]]
	[[Category: Arold, S T]]		[[Category: Arold, S T]]

OCA at 06:02, 22 August 2018

OCA — Wed, 22 Aug 2018 06:02:06 GMT

←Older revision		Revision as of 06:02, 22 August 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5zu0 is ~~ON HOLD~~ ~~until Nov 05 2019~~	+	==Proteobacterial origin of protein arginine methylation and regulation of Complex I assembly by MidA==
-		+	<StructureSection load='5zu0' size='340' side='right' caption='[[5zu0]], [[Resolution\|resolution]] 2.76Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5zu0]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZU0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZU0 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ztz\|5ztz]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Type_II_protein_arginine_methyltransferase Type II protein arginine methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.320 2.1.1.320] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zu0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zu0 OCA], [http://pdbe.org/5zu0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zu0 RCSB], [http://www.ebi.ac.uk/pdbsum/5zu0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zu0 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NDUF7_DICDI NDUF7_DICDI]] Involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) (PubMed:16507593, PubMed:20406883). Acts as an arginine methyltransferase and probably acts by mediating arginine methylation of ndufs2 (By similarity).[UniProtKB:Q7L592]<ref>PMID:16507593</ref> <ref>PMID:20406883</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Type II protein arginine methyltransferase]]
		+	[[Category: Arold, S T]]
		+	[[Category: Hameed, U F.S]]
		+	[[Category: Swaminathan, K]]
		+	[[Category: Mida]]
		+	[[Category: Mitochondrial complex i]]
		+	[[Category: Protein arginine methyl transferase]]
		+	[[Category: Sah]]
		+	[[Category: Sam]]
		+	[[Category: Transferase]]

OCA at 05:21, 14 June 2018

OCA — Thu, 14 Jun 2018 05:21:17 GMT

←Older revision		Revision as of 05:21, 14 June 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5zu0 is ON HOLD	+	The entry 5zu0 is ON HOLD until Nov 05 2019

	Authors:		Authors:

OCA: Protected "5zu0" [edit=sysop:move=sysop]

OCA — Wed, 16 May 2018 03:51:58 GMT

Protected "5zu0" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:51, 16 May 2018

OCA: New page: '''Unreleased structure''' The entry 5zu0 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 16 May 2018 03:51:57 GMT

New page: '''Unreleased structure''' The entry 5zu0 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5zu0 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]