5zul - Revision history

OCA at 09:07, 22 November 2023

OCA — Wed, 22 Nov 2023 09:07:36 GMT

←Older revision		Revision as of 09:07, 22 November 2023
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	<StructureSection load='5zul' size='340' side='right'caption='[[5zul]], [[Resolution\|resolution]] 3.75Å' scene=''>		<StructureSection load='5zul' size='340' side='right'caption='[[5zul]], [[Resolution\|resolution]] 3.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5zul]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Mycmm Mycmm~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZUL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ZUL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5zul]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_marinum_M Mycobacterium marinum M]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZUL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZUL FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~MMAR_2991 (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=216594 MYCMM])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.75Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5zul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zul OCA], [~~http~~://pdbe.org/5zul PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5zul RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5zul PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5zul ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zul OCA], [https://pdbe.org/5zul PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zul RCSB], [https://www.ebi.ac.uk/pdbsum/5zul PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zul ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/B2HF11_MYCMM B2HF11_MYCMM]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 5zul" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5zul" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Heat Shock Protein structures\|Heat Shock Protein structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Mycmm~~]]	+	[[Category: Mycobacterium marinum M]]
-	[[Category: Bhandari, S]]	+	[[Category: Bhandari S]]
-	[[Category: Suguna, K]]	+	[[Category: Suguna K]]
-	~~[[Category: Chaperone]]~~	+
-	~~[[Category: Oligomer]]~~	+
-	~~[[Category: Polydispersity]]~~	+
-	~~[[Category: Shsp~~]]	+

OCA at 06:33, 17 April 2019

OCA — Wed, 17 Apr 2019 06:33:55 GMT

←Older revision		Revision as of 06:33, 17 April 2019
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	==Small heat shock protein from Mycobacterium marinum M : Form-3==		==Small heat shock protein from Mycobacterium marinum M : Form-3==
-	<StructureSection load='5zul' size='340' side='right' caption='[[5zul]], [[Resolution\|resolution]] 3.75Å' scene=''>	+	<StructureSection load='5zul' size='340' side='right'caption='[[5zul]], [[Resolution\|resolution]] 3.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5zul]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZUL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZUL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5zul]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycmm Mycmm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZUL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZUL FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zul OCA], [http://pdbe.org/5zul PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zul RCSB], [http://www.ebi.ac.uk/pdbsum/5zul PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zul ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MMAR_2991 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216594 MYCMM])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zul OCA], [http://pdbe.org/5zul PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zul RCSB], [http://www.ebi.ac.uk/pdbsum/5zul PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zul ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Mycmm]]
	[[Category: Bhandari, S]]		[[Category: Bhandari, S]]
	[[Category: Suguna, K]]		[[Category: Suguna, K]]

OCA at 08:12, 30 January 2019

OCA — Wed, 30 Jan 2019 08:12:38 GMT

←Older revision		Revision as of 08:12, 30 January 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 5zul is ~~ON HOLD until Paper~~ Publication	+	==Small heat shock protein from Mycobacterium marinum M : Form-3==
		+	<StructureSection load='5zul' size='340' side='right' caption='[[5zul]], [[Resolution\|resolution]] 3.75Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5zul]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZUL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZUL FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zul OCA], [http://pdbe.org/5zul PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zul RCSB], [http://www.ebi.ac.uk/pdbsum/5zul PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zul ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Small heat shock proteins (sHSPs) are ATP-independent molecular chaperones present ubiquitously in all kingdoms of life. Their low molecular weight subunits associate to form higher order structures. Under conditions of stress, sHSPs prevent aggregation of substrate proteins by undergoing rapid changes in their conformation or stoichiometry. Polydispersity and dynamic nature of these proteins have made structural investigations through crystallography a daunting task. In pathogens like Mycobacteria, sHSPs are immuno-dominant antigens, enabling survival of the pathogen within the host and contributing to disease persistence. We characterized sHSPs from Mycobacterium marinum M and determined the crystal structure of one of these. The protein crystallized in three different conditions as dodecamers, with dimers arranged in a tetrahedral fashion to form a closed cage-like architecture. Interestingly, we found a pentapeptide bound to the dodecamers revealing one of the modes of sHSP-substrate interaction. Further, we have observed that ATP inhibits the chaperoning activity of the protein.

-	~~Authors:~~ Bhandari, S., ~~Suguna~~, K.	+	Dodecameric structure of a small heat shock protein from Mycobacterium marinum M.,Bhandari S, Biswas S, Chaudhary A, Dutta S, Suguna K Proteins. 2019 Jan 11. doi: 10.1002/prot.25657. PMID:30632633<ref>PMID:30632633</ref>

-	~~Description: Small heat shock protein from Mycobacterium marinum M : Form-3~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Suguna, K]]~~	+	<div class="pdbe-citations 5zul" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Bhandari, S]]		[[Category: Bhandari, S]]
		+	[[Category: Suguna, K]]
		+	[[Category: Chaperone]]
		+	[[Category: Oligomer]]
		+	[[Category: Polydispersity]]
		+	[[Category: Shsp]]

OCA at 03:51, 30 May 2018

OCA — Wed, 30 May 2018 03:51:42 GMT

←Older revision		Revision as of 03:51, 30 May 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5zul is ON HOLD	+	The entry 5zul is ON HOLD until Paper Publication

	Authors: Bhandari, S., Suguna, K.		Authors: Bhandari, S., Suguna, K.

OCA: Protected "5zul" [edit=sysop:move=sysop]

OCA — Wed, 16 May 2018 03:53:50 GMT

Protected "5zul" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:53, 16 May 2018

OCA: New page: '''Unreleased structure''' The entry 5zul is ON HOLD Authors: Bhandari, S., Suguna, K. Description: Small heat shock protein from Mycobacterium marinum M : Form-3 [[Category: Unrelease...

OCA — Wed, 16 May 2018 03:53:49 GMT

New page: '''Unreleased structure''' The entry 5zul is ON HOLD Authors: Bhandari, S., Suguna, K. Description: Small heat shock protein from Mycobacterium marinum M : Form-3 [[Category: Unrelease...

New page

'''Unreleased structure'''

The entry 5zul is ON HOLD

Authors: Bhandari, S., Suguna, K.

Description: Small heat shock protein from Mycobacterium marinum M : Form-3
[[Category: Unreleased Structures]]
[[Category: Suguna, K]]
[[Category: Bhandari, S]]