5zus - Revision history

OCA at 09:07, 22 November 2023

OCA — Wed, 22 Nov 2023 09:07:56 GMT

←Older revision		Revision as of 09:07, 22 November 2023
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	<StructureSection load='5zus' size='340' side='right'caption='[[5zus]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='5zus' size='340' side='right'caption='[[5zus]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5zus]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Norovirus_gii~~.17 Norovirus ~~gii~~.17]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZUS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ZUS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5zus]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Norovirus_GII.17 Norovirus GII.17]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZUS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZUS FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5zus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zus OCA], [~~http~~://pdbe.org/5zus PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5zus RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5zus PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5zus ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zus OCA], [https://pdbe.org/5zus PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zus RCSB], [https://www.ebi.ac.uk/pdbsum/5zus PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zus ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A0E3X5I8_9CALI A0A0E3X5I8_9CALI]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 5zus" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5zus" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Virus coat proteins 3D structures\|Virus coat proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 20:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Norovirus ~~gii~~ 17]]	+	[[Category: Norovirus GII 17]]
-	[[Category: Chen, Y]]	+	[[Category: Chen Y]]
-	[[Category: Li, X]]	+	[[Category: Li X]]
-	~~[[Category: Capsid]]~~	+
-	~~[[Category: Dimer]]~~	+
-	~~[[Category: Hbga recognition]]~~	+
-	~~[[Category: Protruding domain]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 06:34, 17 April 2019

OCA — Wed, 17 Apr 2019 06:34:07 GMT

←Older revision		Revision as of 06:34, 17 April 2019
Line 1:		Line 1:

	==P domain of GII.17-2014/15==		==P domain of GII.17-2014/15==
-	<StructureSection load='5zus' size='340' side='right' caption='[[5zus]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='5zus' size='340' side='right'caption='[[5zus]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5zus]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZUS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZUS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5zus]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Norovirus_gii.17 Norovirus gii.17]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZUS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZUS FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zus OCA], [http://pdbe.org/5zus PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zus RCSB], [http://www.ebi.ac.uk/pdbsum/5zus PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zus ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zus OCA], [http://pdbe.org/5zus PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zus RCSB], [http://www.ebi.ac.uk/pdbsum/5zus PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zus ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human noroviruses (huNoVs), which cause epidemic acute gastroenteritis, recognize histo-blood group antigens (HBGAs) as host attachment factors affecting host susceptibility. HuNoVs are genetically diverse, containing at least 31 genotypes in the two major genogroups (genogroup I [GI] and GII). Three GII genotypes, GII genotype 17 (GII.17), GII.13, and GII.21, form a unique genetic lineage, in which the GII.17 genotype retains the conventional GII HBGA binding site (HBS), while the GII.13/21 genotypes acquire a completely new HBS. To understand the molecular bases behind these evolutionary changes, we solved the crystal structures of the HBGA binding protruding domains of (i) an early GII.17 variant (the 1978 variant) that does not bind or binds weakly to HBGAs, (ii) the new GII.17 variant (the 2014/15 variant) that binds A/B/H antigens strongly via an optimized GII HBS, and (iii) a GII.13 variant (the 2010 variant) that binds the Lewis a (Le(a)) antigen via the new HBS. These serial, high-resolution structural data enable a comprehensive structural comparison to understand the evolutionary changes of the GII.17/13/21 lineage, including the emergence of the new HBS of the GII.13/21 sublineage and the possible HBS optimization of the recent GII.17 variant for an enhanced HBGA binding ability. Our study elucidates the structural adaptations of the GII.17/13/21 lineage through distinct evolutionary paths, which may allow a theory explaining huNoV adaptations and evolutions to be put forward.IMPORTANCE Our understanding of the molecular bases behind the interplays between human noroviruses and their host glycan ligands, as well as their evolutionary changes over time with alterations in their host ligand binding capability and host susceptibility, remains limited. By solving the crystal structures of the glycan ligand binding protruding (P) domains with or without glycan ligands of three representative noroviruses of the GII.17/13/21 genetic lineage, we elucidated the molecular bases of the human norovirus-glycan interactions of this special genetic lineage. We present solid evidence on how noroviruses of this genetic lineage evolved via different evolutionary paths to (i) optimize their glycan binding site for higher glycan binding function and (ii) acquire a completely new glycan binding site for new ligands. Our data shed light on the mechanism of the structural adaptations of human noroviruses through different evolutionary paths, facilitating our understanding of human norovirus adaptations, evolutions, and epidemiology.
		+
		+	Structural Adaptations of Norovirus GII.17/13/21 Lineage through Two Distinct Evolutionary Paths.,Qian Y, Song M, Jiang X, Xia M, Meller J, Tan M, Chen Y, Li X, Rao Z J Virol. 2018 Dec 10;93(1). pii: JVI.01655-18. doi: 10.1128/JVI.01655-18. Print, 2019 Jan 1. PMID:30333166<ref>PMID:30333166</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5zus" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Norovirus gii 17]]
	[[Category: Chen, Y]]		[[Category: Chen, Y]]
	[[Category: Li, X]]		[[Category: Li, X]]

OCA at 07:38, 3 October 2018

OCA — Wed, 03 Oct 2018 07:38:59 GMT

←Older revision		Revision as of 07:38, 3 October 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 5zus is ON HOLD~~	+	==P domain of GII.17-2014/15==
-		+	<StructureSection load='5zus' size='340' side='right' caption='[[5zus]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~Authors: Chen, Y., Li, X.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5zus]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZUS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZUS FirstGlance]. <br>
-	~~Description:~~ P domain of GII.17-2014/15	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zus OCA], [http://pdbe.org/5zus PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zus RCSB], [http://www.ebi.ac.uk/pdbsum/5zus PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zus ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
	[[Category: Chen, Y]]		[[Category: Chen, Y]]
	[[Category: Li, X]]		[[Category: Li, X]]
		+	[[Category: Capsid]]
		+	[[Category: Dimer]]
		+	[[Category: Hbga recognition]]
		+	[[Category: Protruding domain]]
		+	[[Category: Viral protein]]

OCA: Protected "5zus" [edit=sysop:move=sysop]

OCA — Wed, 16 May 2018 03:54:24 GMT

Protected "5zus" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:54, 16 May 2018

OCA: New page: '''Unreleased structure''' The entry 5zus is ON HOLD Authors: Chen, Y., Li, X. Description: P domain of GII.17-2014/15 Category: Unreleased Structures Category: Chen, Y [[Categ...

OCA — Wed, 16 May 2018 03:54:22 GMT

New page: '''Unreleased structure''' The entry 5zus is ON HOLD Authors: Chen, Y., Li, X. Description: P domain of GII.17-2014/15 Category: Unreleased Structures Category: Chen, Y [[Categ...

New page

'''Unreleased structure'''

The entry 5zus is ON HOLD

Authors: Chen, Y., Li, X.

Description: P domain of GII.17-2014/15
[[Category: Unreleased Structures]]
[[Category: Chen, Y]]
[[Category: Li, X]]