OCA at 20:52, 2 December 2018

OCA — Sun, 02 Dec 2018 20:52:22 GMT

←Older revision		Revision as of 20:52, 2 December 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5zva ~~is ON HOLD until Paper Publication~~	+	==APOBEC3F Chimeric Catalytic Domain in Complex with DNA(dC9)==
-		+	<StructureSection load='5zva' size='340' side='right' caption='[[5zva]], [[Resolution\|resolution]] 2.30Å' scene=''>
-	~~Authors~~: ~~Cheng, C~~., ~~Zhang, T~~.L., ~~Wang, C~~.X., ~~Lan~~, W.X., ~~Ding, J~~.P., ~~Cao, C~~.Y.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5zva]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZVA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZVA FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure~~ of ~~APOBEC3F catalytic domain~~ in ~~complex with~~ DNA	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">APOBEC3F ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	[[Category: ~~Ding~~, ~~J.P~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zva OCA], [http://pdbe.org/5zva PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zva RCSB], [http://www.ebi.ac.uk/pdbsum/5zva PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zva ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ABC3G_HUMAN ABC3G_HUMAN]] DNA deaminase (cytidine deaminase) that mediates a form of innate resistance to retroviral infections (at least to HIV-1 infection) by triggering G-to-A hypermutation in the newly synthesized viral DNA. The replacements C-to-U in the minus strand DNA of HIV-1 during reverse transcription, leads to G-to-A transitions in the plus strand. The inhibition of viral replication is either due to the degradation of the minus strand before its integration or to the lethality of the hypermutations. Modification of both DNA strands is not excluded. This antiviral activity is neutralized by the virion infectivity factor (VIF), that prevents the incorporation of APOBEC3G into progeny HIV-1 virions by both inhibiting its translation and/or by inducing its ubiquitination and subsequent degradation by the 26S proteasome. May also prevent the transposition of a subset of retroelements. Binds a variety of RNAs, but does not display detectable APOB, NF1 and NAT1 mRNA editing.<ref>PMID:14557625</ref> <ref>PMID:12167863</ref> <ref>PMID:12808466</ref> <ref>PMID:12809610</ref> <ref>PMID:12808465</ref> <ref>PMID:12859895</ref> <ref>PMID:12970355</ref> <ref>PMID:14528300</ref> <ref>PMID:15031497</ref> <ref>PMID:16527742</ref> <ref>PMID:21123384</ref> <ref>PMID:18288108</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Cao, C Y]]
	[[Category: Cheng, C]]		[[Category: Cheng, C]]
-	[[Category: ~~Lan~~, ~~W.X~~]]	+	[[Category: Ding, J P]]
-	[[Category: ~~Wang~~, C.X]]	+	[[Category: Lan, W X]]
-	[[Category: ~~Cao~~, C.Y]]	+	[[Category: Wang, C X]]
-	[[Category: Zhang, T.L]]	+	[[Category: Zhang, T L]]
		+	[[Category: Apobec3f]]
		+	[[Category: Deamination]]
		+	[[Category: Hiv-1]]
		+	[[Category: Structural protein-dna complex]]

OCA at 05:21, 14 June 2018

OCA — Thu, 14 Jun 2018 05:21:26 GMT

←Older revision		Revision as of 05:21, 14 June 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5zva is ON HOLD	+	The entry 5zva is ON HOLD until Paper Publication

	Authors: Cheng, C., Zhang, T.L., Wang, C.X., Lan, W.X., Ding, J.P., Cao, C.Y.		Authors: Cheng, C., Zhang, T.L., Wang, C.X., Lan, W.X., Ding, J.P., Cao, C.Y.

OCA: Protected "5zva" [edit=sysop:move=sysop]

OCA — Wed, 16 May 2018 03:55:46 GMT

Protected "5zva" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:55, 16 May 2018

OCA: New page: '''Unreleased structure''' The entry 5zva is ON HOLD Authors: Cheng, C., Zhang, T.L., Wang, C.X., Lan, W.X., Ding, J.P., Cao, C.Y. Description: Crystal structure of APOBEC3F catalytic ...

OCA — Wed, 16 May 2018 03:55:45 GMT

New page: '''Unreleased structure''' The entry 5zva is ON HOLD Authors: Cheng, C., Zhang, T.L., Wang, C.X., Lan, W.X., Ding, J.P., Cao, C.Y. Description: Crystal structure of APOBEC3F catalytic ...

New page

'''Unreleased structure'''

The entry 5zva is ON HOLD

Authors: Cheng, C., Zhang, T.L., Wang, C.X., Lan, W.X., Ding, J.P., Cao, C.Y.

Description: Crystal structure of APOBEC3F catalytic domain in complex with DNA
[[Category: Unreleased Structures]]
[[Category: Ding, J.P]]
[[Category: Cheng, C]]
[[Category: Lan, W.X]]
[[Category: Wang, C.X]]
[[Category: Cao, C.Y]]
[[Category: Zhang, T.L]]

5zva - Revision history

OCA at 20:52, 2 December 2018

OCA at 05:21, 14 June 2018

OCA: Protected "5zva" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 5zva is ON HOLD Authors: Cheng, C., Zhang, T.L., Wang, C.X., Lan, W.X., Ding, J.P., Cao, C.Y. Description: Crystal structure of APOBEC3F catalytic ...