5zws - Revision history

OCA at 09:09, 22 November 2023

OCA — Wed, 22 Nov 2023 09:09:44 GMT

←Older revision		Revision as of 09:09, 22 November 2023
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	<StructureSection load='5zws' size='340' side='right'caption='[[5zws]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='5zws' size='340' side='right'caption='[[5zws]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5zws]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZWS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5ZWS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5zws]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZWS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZWS FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">[[~~2m5r~~\|~~2m5r~~]]</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5zws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zws OCA], [~~http~~://pdbe.org/5zws PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5zws RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5zws PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5zws ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zws OCA], [https://pdbe.org/5zws PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zws RCSB], [https://www.ebi.ac.uk/pdbsum/5zws PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zws ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/E9AD06_LEIMA E9AD06_LEIMA]] Carrier of the growing fatty acid chain in fatty acid biosynthesis.[RuleBase:RU000722]	+	[https://www.uniprot.org/uniprot/E9AD06_LEIMA E9AD06_LEIMA] Carrier of the growing fatty acid chain in fatty acid biosynthesis.[RuleBase:RU000722]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arya, R]]
-	[[Category: Kundu, S]]
-	[[Category: Makde, R D]]
-	[[Category: Sharma, B]]
-	[[Category: Acyl carrier protein]]
-	[[Category: Fatty acid biosynthesis]]
	[[Category: Leishmania major]]		[[Category: Leishmania major]]
-	[[Category: ~~Lipid binding protein~~]]	+	[[Category: Arya R]]
		+	[[Category: Kundu S]]
		+	[[Category: Makde RD]]
		+	[[Category: Sharma B]]

OCA at 21:24, 28 October 2020

OCA — Wed, 28 Oct 2020 21:24:43 GMT

←Older revision		Revision as of 21:24, 28 October 2020
Line 1:		Line 1:

	==Crystal structure of apo-acyl carrier protein from Leishmania major==		==Crystal structure of apo-acyl carrier protein from Leishmania major==
-	<StructureSection load='5zws' size='340' side='right' caption='[[5zws]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='5zws' size='340' side='right'caption='[[5zws]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5zws]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZWS OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ZWS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5zws]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZWS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5ZWS FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2m5r\|2m5r]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2m5r\|2m5r]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5zws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zws OCA], [http://pdbe.org/5zws PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zws RCSB], [http://www.ebi.ac.uk/pdbsum/5zws PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zws ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5zws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zws OCA], [http://pdbe.org/5zws PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zws RCSB], [http://www.ebi.ac.uk/pdbsum/5zws PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zws ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Arya, R]]		[[Category: Arya, R]]
	[[Category: Kundu, S]]		[[Category: Kundu, S]]

OCA at 11:59, 16 January 2019

OCA — Wed, 16 Jan 2019 11:59:01 GMT

←Older revision		Revision as of 11:59, 16 January 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 5zws is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of apo-acyl carrier protein from Leishmania major==
		+	<StructureSection load='5zws' size='340' side='right' caption='[[5zws]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5zws]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZWS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZWS FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2m5r\|2m5r]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zws OCA], [http://pdbe.org/5zws PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zws RCSB], [http://www.ebi.ac.uk/pdbsum/5zws PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zws ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/E9AD06_LEIMA E9AD06_LEIMA]] Carrier of the growing fatty acid chain in fatty acid biosynthesis.[RuleBase:RU000722]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Acyl carrier proteins (ACPs) play crucial roles in the biosynthesis of fatty acids, non-ribosomal polypeptides and polyketides. The three-dimensional NMR structure of Leishmania major holo-LmACP, belonging to the type II pathway, has been reported previously, but the structure of its apo-form and its conformational differences with the holo-form remain to be explored. Here we report the crystal structures of apo-LmACP (wild-type and S37A mutant) at 2.0A resolution and compare their key features with the structures of holo-LmACP (wild-type) and other type II ACPs from Escherichia coli and Plasmodium falciparum. The crystal structure of apo-LmACP, which is homologous to other type II ACPs, displays some key structural rearrangements as compared to its holo-structure. Contrary to holo-form, which exists predominantly as a monomer, the apo-form exists as a mixture of monomeric and dimeric population in solution. In contrast to the closed structure of apo-LmACP, holo-LmACP structure was observed in an open conformation as a result of reorganization of specific helices and loops. We propose that the structural changes exhibited by LmACP occur due to the attachment of the phosphopantetheine arm and may be a prerequisite for the initiation of fatty acid synthesis. The movement of helix 3 may also play a role in the dissociation of holo-LmACP from its cognate enzymes of the FAS II pathway.

-	~~Authors: Arya~~, R., Sharma, B., Makde, R.D., ~~Kundu, S~~.	+	A conformational switch from a closed apo- to an open holo-form equips the acyl carrier protein for acyl chain accommodation.,Arya R, Sharma B, Dhembla C, Pal RK, Patel AK, Sundd M, Ghosh B, Makde RD, Kundu S Biochim Biophys Acta Proteins Proteom. 2018 Dec 10;1867(3):163-174. doi:, 10.1016/j.bbapap.2018.12.001. PMID:30543875<ref>PMID:30543875</ref>

-	~~Description: Crystal structure~~ of ~~apo-acyl carrier protein from Leishmania major~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Makde, R.D]]~~	+	<div class="pdbe-citations 5zws" style="background-color:#fffaf0;"></div>
-	~~[[Category: Sharma, B]]~~	+	== References ==
-	~~[[Category: Kundu, S]]~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Arya, R]]		[[Category: Arya, R]]
		+	[[Category: Kundu, S]]
		+	[[Category: Makde, R D]]
		+	[[Category: Sharma, B]]
		+	[[Category: Acyl carrier protein]]
		+	[[Category: Fatty acid biosynthesis]]
		+	[[Category: Leishmania major]]
		+	[[Category: Lipid binding protein]]

OCA at 05:21, 14 June 2018

OCA — Thu, 14 Jun 2018 05:21:58 GMT

←Older revision		Revision as of 05:21, 14 June 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5zws is ON HOLD	+	The entry 5zws is ON HOLD until Paper Publication

	Authors: Arya, R., Sharma, B., Makde, R.D., Kundu, S.		Authors: Arya, R., Sharma, B., Makde, R.D., Kundu, S.
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	Description: Crystal structure of apo-acyl carrier protein from Leishmania major		Description: Crystal structure of apo-acyl carrier protein from Leishmania major
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Makde, R.D]]
	[[Category: Sharma, B]]		[[Category: Sharma, B]]
	[[Category: Kundu, S]]		[[Category: Kundu, S]]
	[[Category: Arya, R]]		[[Category: Arya, R]]
-	[[Category: Makde, R.D]]

OCA: Protected "5zws" [edit=sysop:move=sysop]

OCA — Wed, 23 May 2018 05:53:33 GMT

Protected "5zws" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:53, 23 May 2018

OCA: New page: '''Unreleased structure''' The entry 5zws is ON HOLD Authors: Arya, R., Sharma, B., Makde, R.D., Kundu, S. Description: Crystal structure of apo-acyl carrier protein from Leishmania ma...

OCA — Wed, 23 May 2018 05:53:32 GMT

New page: '''Unreleased structure''' The entry 5zws is ON HOLD Authors: Arya, R., Sharma, B., Makde, R.D., Kundu, S. Description: Crystal structure of apo-acyl carrier protein from Leishmania ma...

New page

'''Unreleased structure'''

The entry 5zws is ON HOLD

Authors: Arya, R., Sharma, B., Makde, R.D., Kundu, S.

Description: Crystal structure of apo-acyl carrier protein from Leishmania major
[[Category: Unreleased Structures]]
[[Category: Sharma, B]]
[[Category: Kundu, S]]
[[Category: Arya, R]]
[[Category: Makde, R.D]]