5zxd - Revision history

OCA at 19:05, 1 August 2018

OCA — Wed, 01 Aug 2018 19:05:40 GMT

←Older revision		Revision as of 19:05, 1 August 2018
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	<StructureSection load='5zxd' size='340' side='right' caption='[[5zxd]], [[Resolution\|resolution]] 2.29Å' scene=''>		<StructureSection load='5zxd' size='340' side='right' caption='[[5zxd]], [[Resolution\|resolution]] 2.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5zxd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZXD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZXD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5zxd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZXD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZXD FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ABCF1, ABC50 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zxd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zxd OCA], [http://pdbe.org/5zxd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zxd RCSB], [http://www.ebi.ac.uk/pdbsum/5zxd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zxd ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zxd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zxd OCA], [http://pdbe.org/5zxd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zxd RCSB], [http://www.ebi.ac.uk/pdbsum/5zxd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zxd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/ABCF1_HUMAN ABCF1_HUMAN]] Isoform 2 is required for efficient Cap- and IRES-mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis.<ref>PMID:19570978</ref>		[[http://www.uniprot.org/uniprot/ABCF1_HUMAN ABCF1_HUMAN]] Isoform 2 is required for efficient Cap- and IRES-mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis.<ref>PMID:19570978</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Gene translation requires the correct selection of start codon AUG in mRNA. ATP-binding cassette subfamily F member 1 (ABCF1) plays a key role in the accuracy of start codon selection. However, the function of human ABCF1 is not clearly understood. Here, we solve the crystal structure of an ATP-bound wild-type human ABCF1 at 2.3-A resolution. The comparative studies indicate that the structure is in a pre-activation intermediate conformation. This conformation is stabilized by the interaction between ATP and protein. Thus, we propose that this conformation is an important step in the activation of ABCF1. This study extends our understanding of ABC (ATP-binding cassette) protein activation at the molecular level.
		+
		+	Crystal Structure of ATP-Bound Human ABCF1 Demonstrates a Unique Conformation of ABC Proteins.,Qu L, Jiang Y, Cheng C, Wu D, Meng B, Chen Z, Zhu Y, Shaw N, Ouyang S, Liu ZJ Structure. 2018 Jun 12. pii: S0969-2126(18)30206-5. doi:, 10.1016/j.str.2018.05.019. PMID:30017566<ref>PMID:30017566</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5zxd" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Jiang, Y]]		[[Category: Jiang, Y]]
	[[Category: Liu, Z J]]		[[Category: Liu, Z J]]

OCA at 07:12, 25 July 2018

OCA — Wed, 25 Jul 2018 07:12:20 GMT

←Older revision		Revision as of 07:12, 25 July 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 5zxd is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of ATP-bound human ABCF1==
-		+	<StructureSection load='5zxd' size='340' side='right' caption='[[5zxd]], [[Resolution\|resolution]] 2.29Å' scene=''>
-	~~Authors~~: Lu, Q., ~~Yan~~, J., ~~Zhi-Jie~~, L.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5zxd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZXD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZXD FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure of ATP~~-~~bound human ABCF1~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	[[Category: ~~Zhi-Jie~~, L]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zxd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zxd OCA], [http://pdbe.org/5zxd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zxd RCSB], [http://www.ebi.ac.uk/pdbsum/5zxd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zxd ProSAT]</span></td></tr>
-	[[Category: ~~Yan~~, J]]	+	</table>
-	[[Category: ~~Lu, Q~~]]	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ABCF1_HUMAN ABCF1_HUMAN]] Isoform 2 is required for efficient Cap- and IRES-mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis.<ref>PMID:19570978</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Jiang, Y]]
		+	[[Category: Liu, Z J]]
		+	[[Category: Qu, L]]
		+	[[Category: Regulator]]
		+	[[Category: Translation]]

OCA at 03:48, 27 June 2018

OCA — Wed, 27 Jun 2018 03:48:34 GMT

←Older revision		Revision as of 03:48, 27 June 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5zxd is ON HOLD	+	The entry 5zxd is ON HOLD until Paper Publication

	Authors: Lu, Q., Yan, J., Zhi-Jie, L.		Authors: Lu, Q., Yan, J., Zhi-Jie, L.

OCA: Protected "5zxd" [edit=sysop:move=sysop]

OCA — Wed, 30 May 2018 03:53:06 GMT

Protected "5zxd" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:53, 30 May 2018

OCA: New page: '''Unreleased structure''' The entry 5zxd is ON HOLD Authors: Lu, Q., Yan, J., Zhi-Jie, L. Description: Crystal structure of ATP-bound human ABCF1 Category: Unreleased Structures [...

OCA — Wed, 30 May 2018 03:53:04 GMT

New page: '''Unreleased structure''' The entry 5zxd is ON HOLD Authors: Lu, Q., Yan, J., Zhi-Jie, L. Description: Crystal structure of ATP-bound human ABCF1 Category: Unreleased Structures [...

New page

'''Unreleased structure'''

The entry 5zxd is ON HOLD

Authors: Lu, Q., Yan, J., Zhi-Jie, L.

Description: Crystal structure of ATP-bound human ABCF1
[[Category: Unreleased Structures]]
[[Category: Zhi-Jie, L]]
[[Category: Yan, J]]
[[Category: Lu, Q]]