5zxf - Revision history

OCA at 10:29, 27 March 2024

OCA — Wed, 27 Mar 2024 10:29:31 GMT

←Older revision		Revision as of 10:29, 27 March 2024
Line 3:		Line 3:
	<StructureSection load='5zxf' size='340' side='right'caption='[[5zxf]], [[Resolution\|resolution]] 1.25Å' scene=''>		<StructureSection load='5zxf' size='340' side='right'caption='[[5zxf]], [[Resolution\|resolution]] 1.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5zxf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZXF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5ZXF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5zxf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZXF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZXF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NUT:4-({(4S,5R)-4,5-BIS(4-CHLOROPHENYL)-2-[4-METHOXY-2-(PROPAN-2-YLOXY)PHENYL]-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}CARBONYL)PIPERAZIN-2-ONE'>NUT</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.25Å</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RING-type_E3_ubiquitin_transferase RING-type E3 ubiquitin transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.2.27 2.3.2.27] </span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NUT:4-({(4S,5R)-4,5-BIS(4-CHLOROPHENYL)-2-[4-METHOXY-2-(PROPAN-2-YLOXY)PHENYL]-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}CARBONYL)PIPERAZIN-2-ONE'>NUT</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5zxf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zxf OCA], [~~http~~://pdbe.org/5zxf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5zxf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5zxf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5zxf ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zxf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zxf OCA], [https://pdbe.org/5zxf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zxf RCSB], [https://www.ebi.ac.uk/pdbsum/5zxf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zxf ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/MDM2_HUMAN MDM2_HUMAN]] Note=Seems to be amplified in certain tumors (including soft tissue sarcomas, osteosarcomas and gliomas). A higher frequency of splice variants lacking p53 binding domain sequences was found in late-stage and high-grade ovarian and bladder carcinomas. Four of the splice variants show loss of p53 binding.	+	[https://www.uniprot.org/uniprot/MDM2_HUMAN MDM2_HUMAN] Note=Seems to be amplified in certain tumors (including soft tissue sarcomas, osteosarcomas and gliomas). A higher frequency of splice variants lacking p53 binding domain sequences was found in late-stage and high-grade ovarian and bladder carcinomas. Four of the splice variants show loss of p53 binding.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MDM2_HUMAN MDM2_HUMAN]] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as an ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and promotes it to proteasomal degradation.<ref>PMID:12821780</ref> <ref>PMID:15053880</ref> <ref>PMID:15195100</ref> <ref>PMID:16337594</ref> <ref>PMID:15632057</ref> <ref>PMID:17290220</ref> <ref>PMID:19098711</ref> <ref>PMID:19219073</ref> <ref>PMID:19965871</ref> <ref>PMID:20858735</ref> <ref>PMID:20173098</ref>	+	[https://www.uniprot.org/uniprot/MDM2_HUMAN MDM2_HUMAN] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as an ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and promotes it to proteasomal degradation.<ref>PMID:12821780</ref> <ref>PMID:15053880</ref> <ref>PMID:15195100</ref> <ref>PMID:16337594</ref> <ref>PMID:15632057</ref> <ref>PMID:17290220</ref> <ref>PMID:19098711</ref> <ref>PMID:19219073</ref> <ref>PMID:19965871</ref> <ref>PMID:20858735</ref> <ref>PMID:20173098</ref>

	==See Also==		==See Also==
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: RING-type E3 ubiquitin transferase]]~~	+	[[Category: Cao CZ]]
-	[[Category: Cao~~, C Z~~]]	+	[[Category: Chen R]]
-	[[Category: Chen, R]]	+	[[Category: Cheng XY]]
-	[[Category: Cheng~~, X Y~~]]	+	[[Category: Huang YQ]]
-	[[Category: Huang~~, Y Q~~]]	+	[[Category: Kuang ZK]]
-	[[Category: Kuang~~, Z K~~]]	+	[[Category: Pi N]]
-	[[Category: Pi, N]]	+	[[Category: Su ZD]]
-	[[Category: Su~~, Z D~~]]	+	[[Category: Zhao ZT]]
-	[[Category: Zhao~~, Z T~~]]	+	[[Category: Zhou JJ]]
-	[[Category: Zhou~~, J J]]~~	+
-	~~[[Category: Cell cycle]]~~	+
-	~~[[Category: P53~~]]	+

OCA at 21:24, 28 October 2020

OCA — Wed, 28 Oct 2020 21:24:54 GMT

←Older revision		Revision as of 21:24, 28 October 2020
Line 1:		Line 1:

	==The 1.25A Crystal structure of His6-tagged Mdm2 in complex with nutlin-3a==		==The 1.25A Crystal structure of His6-tagged Mdm2 in complex with nutlin-3a==
-	<StructureSection load='5zxf' size='340' side='right' caption='[[5zxf]], [[Resolution\|resolution]] 1.25Å' scene=''>	+	<StructureSection load='5zxf' size='340' side='right'caption='[[5zxf]], [[Resolution\|resolution]] 1.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5zxf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZXF OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ZXF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5zxf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZXF OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5ZXF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NUT:4-({(4S,5R)-4,5-BIS(4-CHLOROPHENYL)-2-[4-METHOXY-2-(PROPAN-2-YLOXY)PHENYL]-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}CARBONYL)PIPERAZIN-2-ONE'>NUT</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NUT:4-({(4S,5R)-4,5-BIS(4-CHLOROPHENYL)-2-[4-METHOXY-2-(PROPAN-2-YLOXY)PHENYL]-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}CARBONYL)PIPERAZIN-2-ONE'>NUT</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RING-type_E3_ubiquitin_transferase RING-type E3 ubiquitin transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.2.27 2.3.2.27] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RING-type_E3_ubiquitin_transferase RING-type E3 ubiquitin transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.2.27 2.3.2.27] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5zxf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zxf OCA], [http://pdbe.org/5zxf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zxf RCSB], [http://www.ebi.ac.uk/pdbsum/5zxf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zxf ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5zxf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zxf OCA], [http://pdbe.org/5zxf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zxf RCSB], [http://www.ebi.ac.uk/pdbsum/5zxf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zxf ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 12:		Line 12:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/MDM2_HUMAN MDM2_HUMAN]] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as an ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and promotes it to proteasomal degradation.<ref>PMID:12821780</ref> <ref>PMID:15053880</ref> <ref>PMID:15195100</ref> <ref>PMID:16337594</ref> <ref>PMID:15632057</ref> <ref>PMID:17290220</ref> <ref>PMID:19098711</ref> <ref>PMID:19219073</ref> <ref>PMID:19965871</ref> <ref>PMID:20858735</ref> <ref>PMID:20173098</ref>		[[http://www.uniprot.org/uniprot/MDM2_HUMAN MDM2_HUMAN]] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as an ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and promotes it to proteasomal degradation.<ref>PMID:12821780</ref> <ref>PMID:15053880</ref> <ref>PMID:15195100</ref> <ref>PMID:16337594</ref> <ref>PMID:15632057</ref> <ref>PMID:17290220</ref> <ref>PMID:19098711</ref> <ref>PMID:19219073</ref> <ref>PMID:19965871</ref> <ref>PMID:20858735</ref> <ref>PMID:20173098</ref>
		+
		+	==See Also==
		+	*[[MDM2 3D structures\|MDM2 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: RING-type E3 ubiquitin transferase]]		[[Category: RING-type E3 ubiquitin transferase]]
	[[Category: Cao, C Z]]		[[Category: Cao, C Z]]

OCA at 06:02, 22 August 2018

OCA — Wed, 22 Aug 2018 06:02:03 GMT

←Older revision		Revision as of 06:02, 22 August 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The ~~entry~~ 5zxf ~~is ON HOLD~~	+	==The 1.25A Crystal structure of His6-tagged Mdm2 in complex with nutlin-3a==
-		+	<StructureSection load='5zxf' size='340' side='right' caption='[[5zxf]], [[Resolution\|resolution]] 1.25Å' scene=''>
-	~~Authors~~: ~~Cheng, X~~.Y.~~, Su, Z~~.D., Pi, N., ~~Cao, C~~.Z., ~~Zhao, Z~~.T., ~~Zhou~~, J.J., ~~Chen, R~~., ~~Kuang, Z~~.K., ~~Huang, Y~~.Q.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5zxf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZXF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZXF FirstGlance]. <br>
-	~~Description~~: ~~The 1~~.~~25A Crystal structure~~ of ~~His6~~-~~tagged Mdm2 in~~ complex ~~with nutlin~~-3a	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NUT:4-({(4S,5R)-4,5-BIS(4-CHLOROPHENYL)-2-[4-METHOXY-2-(PROPAN-2-YLOXY)PHENYL]-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}CARBONYL)PIPERAZIN-2-ONE'>NUT</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RING-type_E3_ubiquitin_transferase RING-type E3 ubiquitin transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.2.27 2.3.2.27] </span></td></tr>
-	[[Category: ~~Huang~~, ~~Y.Q~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zxf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zxf OCA], [http://pdbe.org/5zxf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zxf RCSB], [http://www.ebi.ac.uk/pdbsum/5zxf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zxf ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/MDM2_HUMAN MDM2_HUMAN]] Note=Seems to be amplified in certain tumors (including soft tissue sarcomas, osteosarcomas and gliomas). A higher frequency of splice variants lacking p53 binding domain sequences was found in late-stage and high-grade ovarian and bladder carcinomas. Four of the splice variants show loss of p53 binding.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MDM2_HUMAN MDM2_HUMAN]] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as an ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and promotes it to proteasomal degradation.<ref>PMID:12821780</ref> <ref>PMID:15053880</ref> <ref>PMID:15195100</ref> <ref>PMID:16337594</ref> <ref>PMID:15632057</ref> <ref>PMID:17290220</ref> <ref>PMID:19098711</ref> <ref>PMID:19219073</ref> <ref>PMID:19965871</ref> <ref>PMID:20858735</ref> <ref>PMID:20173098</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: RING-type E3 ubiquitin transferase]]
		+	[[Category: Cao, C Z]]
	[[Category: Chen, R]]		[[Category: Chen, R]]
-	[[Category: ~~Cao~~, C.Z]]	+	[[Category: Cheng, X Y]]
		+	[[Category: Huang, Y Q]]
		+	[[Category: Kuang, Z K]]
	[[Category: Pi, N]]		[[Category: Pi, N]]
-	[[Category: ~~Zhao~~, Z.T]]	+	[[Category: Su, Z D]]
-	[[Category: ~~Kuang~~, Z.K]]	+	[[Category: Zhao, Z T]]
-	[[Category: ~~Cheng~~, ~~X.Y~~]]	+	[[Category: Zhou, J J]]
-	[[Category: ~~Zhou, J.J~~]]	+	[[Category: Cell cycle]]
-	[[Category: ~~Su, Z.D~~]]	+	[[Category: P53]]

OCA at 03:53, 11 July 2018

OCA — Wed, 11 Jul 2018 03:53:02 GMT

←Older revision		Revision as of 03:53, 11 July 2018
Line 5:		Line 5:
	Authors: Cheng, X.Y., Su, Z.D., Pi, N., Cao, C.Z., Zhao, Z.T., Zhou, J.J., Chen, R., Kuang, Z.K., Huang, Y.Q.		Authors: Cheng, X.Y., Su, Z.D., Pi, N., Cao, C.Z., Zhao, Z.T., Zhou, J.J., Chen, R., Kuang, Z.K., Huang, Y.Q.

-	Description: The 1.~~12A~~ Crystal structure of ~~HIS6~~-tagged Mdm2 in complex with nutlin-3a	+	Description: The 1.25A Crystal structure of His6-tagged Mdm2 in complex with nutlin-3a
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Huang, Y.Q]]		[[Category: Huang, Y.Q]]

OCA: Protected "5zxf" [edit=sysop:move=sysop]

OCA — Wed, 30 May 2018 03:53:23 GMT

Protected "5zxf" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:53, 30 May 2018

OCA: New page: '''Unreleased structure''' The entry 5zxf is ON HOLD Authors: Cheng, X.Y., Su, Z.D., Pi, N., Cao, C.Z., Zhao, Z.T., Zhou, J.J., Chen, R., Kuang, Z.K., Huang, Y.Q. Description: The 1.12...

OCA — Wed, 30 May 2018 03:53:22 GMT

New page: '''Unreleased structure''' The entry 5zxf is ON HOLD Authors: Cheng, X.Y., Su, Z.D., Pi, N., Cao, C.Z., Zhao, Z.T., Zhou, J.J., Chen, R., Kuang, Z.K., Huang, Y.Q. Description: The 1.12...

New page

'''Unreleased structure'''

The entry 5zxf is ON HOLD

Authors: Cheng, X.Y., Su, Z.D., Pi, N., Cao, C.Z., Zhao, Z.T., Zhou, J.J., Chen, R., Kuang, Z.K., Huang, Y.Q.

Description: The 1.12A Crystal structure of HIS6-tagged Mdm2 in complex with nutlin-3a
[[Category: Unreleased Structures]]
[[Category: Huang, Y.Q]]
[[Category: Chen, R]]
[[Category: Cao, C.Z]]
[[Category: Pi, N]]
[[Category: Zhao, Z.T]]
[[Category: Kuang, Z.K]]
[[Category: Cheng, X.Y]]
[[Category: Zhou, J.J]]
[[Category: Su, Z.D]]