5zxv - Revision history

OCA at 09:10, 22 November 2023

OCA — Wed, 22 Nov 2023 09:10:08 GMT

←Older revision		Revision as of 09:10, 22 November 2023
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	<StructureSection load='5zxv' size='340' side='right'caption='[[5zxv]], [[Resolution\|resolution]] 4.48Å' scene=''>		<StructureSection load='5zxv' size='340' side='right'caption='[[5zxv]], [[Resolution\|resolution]] 4.48Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5zxv]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZXV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5ZXV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5zxv]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Middle_East_respiratory_syndrome-related_coronavirus Middle East respiratory syndrome-related coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZXV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZXV FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5zxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zxv OCA], [~~http~~://pdbe.org/5zxv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5zxv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5zxv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5zxv ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 4.482Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zxv OCA], [https://pdbe.org/5zxv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zxv RCSB], [https://www.ebi.ac.uk/pdbsum/5zxv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zxv ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SPIKE_MERS1 SPIKE_MERS1] Attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Interacts with host DPP4 to mediate virla entry.[HAMAP-Rule:MF_04099]<ref>PMID:23486063</ref> Mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Wang, X~~]]	+	[[Category: Middle East respiratory syndrome-related coronavirus]]
-	[[Category: ~~Zhang, S~~]]	+	[[Category: Wang X]]
-	[[Category: ~~Antibody]]~~	+	[[Category: Zhang S]]
-	~~[[Category: Viral protein~~]]	+

OCA at 21:24, 28 October 2020

OCA — Wed, 28 Oct 2020 21:24:56 GMT

←Older revision		Revision as of 21:24, 28 October 2020
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	==Structural definition of a unique neutralization epitope on the receptor-binding domain of MERS-CoV spike glycoprotein==		==Structural definition of a unique neutralization epitope on the receptor-binding domain of MERS-CoV spike glycoprotein==
-	<StructureSection load='5zxv' size='340' side='right' caption='[[5zxv]], [[Resolution\|resolution]] 4.48Å' scene=''>	+	<StructureSection load='5zxv' size='340' side='right'caption='[[5zxv]], [[Resolution\|resolution]] 4.48Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5zxv]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZXV OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ZXV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5zxv]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZXV OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5ZXV FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5zxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zxv OCA], [http://pdbe.org/5zxv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zxv RCSB], [http://www.ebi.ac.uk/pdbsum/5zxv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zxv ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5zxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zxv OCA], [http://pdbe.org/5zxv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zxv RCSB], [http://www.ebi.ac.uk/pdbsum/5zxv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zxv ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 5zxv" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5zxv" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Sandbox 3001\|Sandbox 3001]]
		+	*[[Spike protein\|Spike protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Wang, X]]		[[Category: Wang, X]]
	[[Category: Zhang, S]]		[[Category: Zhang, S]]
	[[Category: Antibody]]		[[Category: Antibody]]
	[[Category: Viral protein]]		[[Category: Viral protein]]

OCA at 07:12, 25 July 2018

OCA — Wed, 25 Jul 2018 07:12:31 GMT

←Older revision		Revision as of 07:12, 25 July 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 5zxv is ~~ON HOLD until Paper~~ Publication	+	==Structural definition of a unique neutralization epitope on the receptor-binding domain of MERS-CoV spike glycoprotein==
		+	<StructureSection load='5zxv' size='340' side='right' caption='[[5zxv]], [[Resolution\|resolution]] 4.48Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5zxv]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZXV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZXV FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zxv OCA], [http://pdbe.org/5zxv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zxv RCSB], [http://www.ebi.ac.uk/pdbsum/5zxv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zxv ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The major mechanism of antibody-mediated neutralization of the Middle East respiratory syndrome coronavirus (MERS-CoV) involves competition with the cellular receptor dipeptidyl peptidase 4 (DPP4) for binding to the receptor-binding domain (RBD) of the spike (S) glycoprotein. Here, we report a unique epitope and unusual neutralizing mechanism of the isolated human antibody MERS-4. Structurally, MERS-4 approached the RBD from the outside of the RBD-DPP4 binding interface. Such binding resulted in the folding of the beta5-beta6 loop toward a shallow groove on the RBD interface critical for accommodating DPP4. The key residues for binding are identified through site-directed mutagenesis. Structural modeling revealed that MERS-4 binds to RBD only in the "up" position in the S trimer. Furthermore, MERS-4 demonstrated synergy with several reported antibodies. These results indicate that MERS-4 neutralizes MERS-CoV by indirect rather than direct competition with DPP4. This mechanism provides a valuable addition for the combined use of antibodies against MERS-CoV infection.

-	~~Authors~~:	+	Structural Definition of a Unique Neutralization Epitope on the Receptor-Binding Domain of MERS-CoV Spike Glycoprotein.,Zhang S, Zhou P, Wang P, Li Y, Jiang L, Jia W, Wang H, Fan A, Wang D, Shi X, Fang X, Hammel M, Wang S, Wang X, Zhang L Cell Rep. 2018 Jul 10;24(2):441-452. doi: 10.1016/j.celrep.2018.06.041. PMID:29996104<ref>PMID:29996104</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5zxv" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Wang, X]]
		+	[[Category: Zhang, S]]
		+	[[Category: Antibody]]
		+	[[Category: Viral protein]]

OCA at 05:05, 18 July 2018

OCA — Wed, 18 Jul 2018 05:05:50 GMT

←Older revision		Revision as of 05:05, 18 July 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5zxv is ON HOLD	+	The entry 5zxv is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5zxv" [edit=sysop:move=sysop]

OCA — Wed, 30 May 2018 03:55:25 GMT

Protected "5zxv" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:55, 30 May 2018

OCA: New page: '''Unreleased structure''' The entry 5zxv is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 30 May 2018 03:55:24 GMT

New page: '''Unreleased structure''' The entry 5zxv is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5zxv is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]