5zy8 - Revision history

OCA at 09:10, 22 November 2023

OCA — Wed, 22 Nov 2023 09:10:12 GMT

←Older revision		Revision as of 09:10, 22 November 2023
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	<StructureSection load='5zy8' size='340' side='right'caption='[[5zy8]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='5zy8' size='340' side='right'caption='[[5zy8]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5zy8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Myctu Myctu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZY8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZY8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5zy8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZY8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZY8 FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~Rv0637~~, ~~MTCY20H10.18 (~~[~~https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU~~]~~), LH57_03445 ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=83332 MYCTU])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.899Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zy8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zy8 OCA], [https://pdbe.org/5zy8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zy8 RCSB], [https://www.ebi.ac.uk/pdbsum/5zy8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zy8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zy8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zy8 OCA], [https://pdbe.org/5zy8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zy8 RCSB], [https://www.ebi.ac.uk/pdbsum/5zy8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zy8 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Y637_MYCTU Y637_MYCTU]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Myctu~~]]	+	[[Category: Mycobacterium tuberculosis H37Rv]]
-	[[Category: Basak, A]]	+	[[Category: Basak A]]
-	[[Category: Bhattacharyya, S]]	+	[[Category: Bhattacharyya S]]
-	[[Category: Biswas, R]]	+	[[Category: Biswas R]]
-	[[Category: Das~~, A K~~]]	+	[[Category: Das AK]]
-	[[Category: Singh~~, B K]]~~	+	[[Category: Singh BK]]
-	~~[[Category: Complex]]~~	+
-	~~[[Category: Dehydratase]]~~	+
-	~~[[Category: Heterodimer]]~~	+
-	~~[[Category: Hot-dog fold]]~~	+
-	~~[[Category: Lyase~~]]	+

OCA at 07:15, 9 March 2022

OCA — Wed, 09 Mar 2022 07:15:51 GMT

←Older revision		Revision as of 07:15, 9 March 2022
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	<StructureSection load='5zy8' size='340' side='right'caption='[[5zy8]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='5zy8' size='340' side='right'caption='[[5zy8]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5zy8]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZY8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ZY8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5zy8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZY8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZY8 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5zy8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zy8 OCA], [~~http~~://pdbe.org/5zy8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5zy8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5zy8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5zy8 ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rv0637, MTCY20H10.18 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU]), LH57_03445 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zy8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zy8 OCA], [https://pdbe.org/5zy8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zy8 RCSB], [https://www.ebi.ac.uk/pdbsum/5zy8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zy8 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Comprehending the molecular strategies employed by Mycobacterium tuberculosis (Mtb) in FAS-II regulation is of paramount significance in order to curb tuberculosis (TB) progression. Mtb employs two sets of dehydratases, namely HadAB and HadBC (beta-hydroxy acyl ACP dehydratase), for the regulation of the Fatty Acid Synthase (FAS-II) pathway. We have utilized the Sequence similarity network (SSN) to comprehend the presence of two copies of the dehydratase gene in Mtb. This analysis groups HadC and HadA in different clusters, which could be attributed to the variability in their physiological role with respect to the acyl chain uptake. Our study reveals structural details pertaining to the crystal structure of the last remaining enzyme of the FAS-II pathway. It provides insights into the highly flexible hot-dog helix (alpha-HD) and substrate regulatory loop. Additionally, mutational studies assisted in establishing the role of the C-terminal end in HadC of HadBC in the regulation of Acyl Carrier Protein (AcpM) mediated interactions. Complemented with SPR and MD simulation studies, this work provides the first evidence of the molecular mechanisms involved in the differential binding affinity of the AcpM towards both mtbHadAB and mtbHadBC.
		+
		+	The C-terminal end of mycobacterial HadBC regulates AcpM interaction during the FAS-II pathway: a structural perspective.,Singh BK, Biswas R, Bhattacharyya S, Basak A, Das AK FEBS J. 2022 Feb 17. doi: 10.1111/febs.16405. PMID:35175661<ref>PMID:35175661</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5zy8" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Myctu]]
	[[Category: Basak, A]]		[[Category: Basak, A]]
	[[Category: Bhattacharyya, S]]		[[Category: Bhattacharyya, S]]

OCA at 05:25, 12 June 2019

OCA — Wed, 12 Jun 2019 05:25:04 GMT

←Older revision		Revision as of 05:25, 12 June 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5zy8 is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of C terminal truncated HadBC (3R-Hydroxyacyl-ACP Dehydratase) complex from Mycobacterium tuberculosis==
-		+	<StructureSection load='5zy8' size='340' side='right'caption='[[5zy8]], [[Resolution\|resolution]] 2.90Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5zy8]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZY8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZY8 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zy8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zy8 OCA], [http://pdbe.org/5zy8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zy8 RCSB], [http://www.ebi.ac.uk/pdbsum/5zy8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zy8 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Basak, A]]
		+	[[Category: Bhattacharyya, S]]
		+	[[Category: Biswas, R]]
		+	[[Category: Das, A K]]
		+	[[Category: Singh, B K]]
		+	[[Category: Complex]]
		+	[[Category: Dehydratase]]
		+	[[Category: Heterodimer]]
		+	[[Category: Hot-dog fold]]
		+	[[Category: Lyase]]

OCA at 06:06, 10 October 2018

OCA — Wed, 10 Oct 2018 06:06:05 GMT

←Older revision		Revision as of 06:06, 10 October 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5zy8 is ON HOLD	+	The entry 5zy8 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5zy8" [edit=sysop:move=sysop]

OCA — Wed, 30 May 2018 03:56:17 GMT

Protected "5zy8" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:56, 30 May 2018

OCA: New page: '''Unreleased structure''' The entry 5zy8 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 30 May 2018 03:56:15 GMT

New page: '''Unreleased structure''' The entry 5zy8 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5zy8 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]