6a20 - Revision history

OCA at 09:14, 22 November 2023

OCA — Wed, 22 Nov 2023 09:14:30 GMT

←Older revision		Revision as of 09:14, 22 November 2023
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	==Crystal Structure of auto-inhibited Kinesin-3 KIF13B==		==Crystal Structure of auto-inhibited Kinesin-3 KIF13B==
-	<StructureSection load='6a20' size='340' side='right' caption='[[6a20]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='6a20' size='340' side='right'caption='[[6a20]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6a20]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A20 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6A20 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6a20]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A20 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6A20 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Kif13b ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6a20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a20 OCA], [~~http~~://pdbe.org/6a20 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6a20 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6a20 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6a20 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6a20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a20 OCA], [https://pdbe.org/6a20 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6a20 RCSB], [https://www.ebi.ac.uk/pdbsum/6a20 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6a20 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A0G2K8Z9_RAT A0A0G2K8Z9_RAT]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 6a20" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6a20" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Kinesin 3D Structures\|Kinesin 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Buffalo rat~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Feng, W~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: ~~Ren, J Q~~]]	+	[[Category: Feng W]]
-	[[Category: ~~Wang, S~~]]	+	[[Category: Ren JQ]]
-	[[Category: ~~Atpase]]~~	+	[[Category: Wang S]]
-	~~[[Category: Kinesin]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 06:18, 2 January 2019

OCA — Wed, 02 Jan 2019 06:18:08 GMT

←Older revision		Revision as of 06:18, 2 January 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6a20 is ~~ON HOLD until Paper~~ Publication	+	==Crystal Structure of auto-inhibited Kinesin-3 KIF13B==
		+	<StructureSection load='6a20' size='340' side='right' caption='[[6a20]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6a20]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A20 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6A20 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Kif13b ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6a20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a20 OCA], [http://pdbe.org/6a20 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6a20 RCSB], [http://www.ebi.ac.uk/pdbsum/6a20 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6a20 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In kinesin-3, the coiled-coil 1 (CC1) can sequester the preceding neck coil (NC) for autoinhibition, but the underlying mechanism is poorly understood. Here, we determined the structures of the uninhibited motor domain (MD)-NC dimer and inhibited MD-NC-CC1 monomer of kinesin-3 KIF13B. In the MD-NC-CC1 monomer, CC1 is broken into two short helices that unexpectedly interact with both the NC and the MD. Compared with the MD-NC dimer, the CC1-mediated integration of NC and MD not only blocks the NC dimer formation, but also prevents the neck linker (NL) undocking and the ADP release from the MD. Mutations of the essential residues in the interdomain interaction interface in the MD-NC-CC1 monomer restored the MD activity. Thus, CC1 fastens the neck domain and MD and inhibits both NC and NL. This CC1-mediated lockdown of the entire neck domain may represent a paradigm for kinesin autoinhibition that could be applicable to other kinesin-3 motors.

-	~~Authors: Ren~~, J~~.Q.~~, Wang, S., ~~Feng~~, W.	+	Coiled-coil 1-mediated fastening of the neck and motor domains for kinesin-3 autoinhibition.,Ren J, Wang S, Chen H, Wang W, Huo L, Feng W Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E11933-E11942. doi:, 10.1073/pnas.1811209115. Epub 2018 Nov 21. PMID:30463954<ref>PMID:30463954</ref>

-	~~Description: Crystal Structure~~ of ~~auto~~-~~inhibited Kinesin~~-~~3 KIF13B~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	[[Category: ~~Ren, J.Q~~]]	+	<div class="pdbe-citations 6a20" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Buffalo rat]]
	[[Category: Feng, W]]		[[Category: Feng, W]]
		+	[[Category: Ren, J Q]]
	[[Category: Wang, S]]		[[Category: Wang, S]]
		+	[[Category: Atpase]]
		+	[[Category: Kinesin]]
		+	[[Category: Transport protein]]

OCA at 06:15, 14 November 2018

OCA — Wed, 14 Nov 2018 06:15:41 GMT

←Older revision		Revision as of 06:15, 14 November 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6a20 is ON HOLD	+	The entry 6a20 is ON HOLD until Paper Publication

	Authors: Ren, J.Q., Wang, S., Feng, W.		Authors: Ren, J.Q., Wang, S., Feng, W.

OCA: Protected "6a20" [edit=sysop:move=sysop]

OCA — Thu, 14 Jun 2018 05:32:58 GMT

Protected "6a20" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:32, 14 June 2018

OCA: New page: '''Unreleased structure''' The entry 6a20 is ON HOLD Authors: Ren, J.Q., Wang, S., Feng, W. Description: Crystal Structure of auto-inhibited Kinesin-3 KIF13B [[Category: Unreleased Str...

OCA — Thu, 14 Jun 2018 05:32:56 GMT

New page: '''Unreleased structure''' The entry 6a20 is ON HOLD Authors: Ren, J.Q., Wang, S., Feng, W. Description: Crystal Structure of auto-inhibited Kinesin-3 KIF13B [[Category: Unreleased Str...

New page

'''Unreleased structure'''

The entry 6a20 is ON HOLD

Authors: Ren, J.Q., Wang, S., Feng, W.

Description: Crystal Structure of auto-inhibited Kinesin-3 KIF13B
[[Category: Unreleased Structures]]
[[Category: Ren, J.Q]]
[[Category: Feng, W]]
[[Category: Wang, S]]