6a2v - Revision history

OCA at 09:15, 22 November 2023

OCA — Wed, 22 Nov 2023 09:15:38 GMT

←Older revision		Revision as of 09:15, 22 November 2023
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	<StructureSection load='6a2v' size='340' side='right'caption='[[6a2v]], [[Resolution\|resolution]] 2.59Å' scene=''>		<StructureSection load='6a2v' size='340' side='right'caption='[[6a2v]], [[Resolution\|resolution]] 2.59Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6a2v]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Campylobacter_jejuni_jejuni~~ Campylobacter jejuni jejuni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A2V OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6A2V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6a2v]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Campylobacter_jejuni_subsp._jejuni Campylobacter jejuni subsp. jejuni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A2V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6A2V FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=MSE:SELENOMETHIONINE'>MSE</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.588Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~CV369_03455 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=32022 Campylobacter jejuni jejuni])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6a2v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a2v OCA], [~~http~~://pdbe.org/6a2v PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6a2v RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6a2v PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6a2v ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6a2v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a2v OCA], [https://pdbe.org/6a2v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6a2v RCSB], [https://www.ebi.ac.uk/pdbsum/6a2v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6a2v ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Campylobacter jejuni jejuni]]	+	[[Category: Campylobacter jejuni subsp. jejuni]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Jobichen, C]]	+	[[Category: Jobichen C]]
-	[[Category: Sivaraman, J]]	+	[[Category: Sivaraman J]]
-	~~[[Category: Hemolysin coregulated protein]]~~	+
-	~~[[Category: Structural protein]]~~	+
-	~~[[Category: Type vi secretion system protein~~]]	+

OCA at 21:25, 28 October 2020

OCA — Wed, 28 Oct 2020 21:25:45 GMT

←Older revision		Revision as of 21:25, 28 October 2020
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	==Crystal structure of Hcp protein==		==Crystal structure of Hcp protein==
-	<StructureSection load='6a2v' size='340' side='right' caption='[[6a2v]], [[Resolution\|resolution]] 2.59Å' scene=''>	+	<StructureSection load='6a2v' size='340' side='right'caption='[[6a2v]], [[Resolution\|resolution]] 2.59Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6a2v]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A2V OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6A2V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6a2v]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Campylobacter_jejuni_jejuni Campylobacter jejuni jejuni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A2V OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6A2V FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6a2v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a2v OCA], [http://pdbe.org/6a2v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6a2v RCSB], [http://www.ebi.ac.uk/pdbsum/6a2v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6a2v ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CV369_03455 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=32022 Campylobacter jejuni jejuni])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6a2v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a2v OCA], [http://pdbe.org/6a2v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6a2v RCSB], [http://www.ebi.ac.uk/pdbsum/6a2v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6a2v ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Campylobacter jejuni jejuni]]
		+	[[Category: Large Structures]]
	[[Category: Jobichen, C]]		[[Category: Jobichen, C]]
	[[Category: Sivaraman, J]]		[[Category: Sivaraman, J]]

OCA at 19:43, 19 September 2018

OCA — Wed, 19 Sep 2018 19:43:15 GMT

←Older revision		Revision as of 19:43, 19 September 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6a2v is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of Hcp protein==
		+	<StructureSection load='6a2v' size='340' side='right' caption='[[6a2v]], [[Resolution\|resolution]] 2.59Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6a2v]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A2V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6A2V FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6a2v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a2v OCA], [http://pdbe.org/6a2v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6a2v RCSB], [http://www.ebi.ac.uk/pdbsum/6a2v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6a2v ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Type VI Secretion System (T6SS) provides enhanced virulence to Campylobacter jejuni and has been associated with a high incidence of bloody diarrhea. The hemolysin-coregulated protein (Hcp)-the hallmark of the T6SS-can act as a structural and effector protein. Unlike other T6SS-harboring bacteria, which possess multiple Hcp proteins each performing different functions, C. jejuni possesses only one Hcp protein, and its structural and functional role has not been elucidated previously. Here, we report the structure and functional studies of Hcp from C. jejuni. We found similarities between the hexameric ring structure of Hcp-Cj and that of Hcp3 from Pseudomonas aeruginosa. Through functional studies, we showed two roles for Hcp-Cj i.e., in cytotoxicity towards HepG2 cells and in biofilm formation in C. jejuni. In structure-based mutational analyses, we showed that an Arg-to-Ala mutation at position 30 within the extended loop results in a significant decrease in cytotoxicity, suggesting a role for this loop in binding to the host cell. However, this mutation does not affect its biofilm formation function. Collectively, this study supports the dual role of Hcp-Cj as a structural and effector protein in C. jejuni. This article is protected by copyright. All rights reserved.

-	~~Authors: Jobichen~~, C., Sivaraman, J.	+	Structural basis for the pathogenesis of Campylobacter jejuni Hcp1, a structural and effector protein of the type six secretion system.,Noreen Z, Jobichen C, Abbasi R, Seetharaman J, Sivaraman J, Bohkhari H FEBS J. 2018 Sep 7. doi: 10.1111/febs.14650. PMID:30194714<ref>PMID:30194714</ref>

-	~~Description: Crystal structure~~ of ~~Hcp protein~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
		+	<div class="pdbe-citations 6a2v" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Jobichen, C]]		[[Category: Jobichen, C]]
	[[Category: Sivaraman, J]]		[[Category: Sivaraman, J]]
		+	[[Category: Hemolysin coregulated protein]]
		+	[[Category: Structural protein]]
		+	[[Category: Type vi secretion system protein]]

OCA at 05:30, 4 July 2018

OCA — Wed, 04 Jul 2018 05:30:49 GMT

←Older revision		Revision as of 05:30, 4 July 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6a2v is ON HOLD	+	The entry 6a2v is ON HOLD until Paper Publication

	Authors: Jobichen, C., Sivaraman, J.		Authors: Jobichen, C., Sivaraman, J.

OCA at 03:51, 27 June 2018

OCA — Wed, 27 Jun 2018 03:51:09 GMT

←Older revision		Revision as of 03:51, 27 June 2018
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	Authors: Jobichen, C., Sivaraman, J.		Authors: Jobichen, C., Sivaraman, J.

-	Description: Crystal structure of Hcp protein.	+	Description: Crystal structure of Hcp protein
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Jobichen, C]]		[[Category: Jobichen, C]]
	[[Category: Sivaraman, J]]		[[Category: Sivaraman, J]]

OCA: Protected "6a2v" [edit=sysop:move=sysop]

OCA — Wed, 20 Jun 2018 03:56:07 GMT

Protected "6a2v" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:56, 20 June 2018

OCA: New page: '''Unreleased structure''' The entry 6a2v is ON HOLD Authors: Jobichen, C., Sivaraman, J. Description: Crystal structure of Hcp protein. Category: Unreleased Structures [[Category:...

OCA — Wed, 20 Jun 2018 03:56:05 GMT

New page: '''Unreleased structure''' The entry 6a2v is ON HOLD Authors: Jobichen, C., Sivaraman, J. Description: Crystal structure of Hcp protein. Category: Unreleased Structures [[Category:...

New page

'''Unreleased structure'''

The entry 6a2v is ON HOLD

Authors: Jobichen, C., Sivaraman, J.

Description: Crystal structure of Hcp protein.
[[Category: Unreleased Structures]]
[[Category: Jobichen, C]]
[[Category: Sivaraman, J]]