6a51 - Revision history

OCA at 06:42, 26 June 2019

OCA — Wed, 26 Jun 2019 06:42:28 GMT

←Older revision		Revision as of 06:42, 26 June 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6a51 is ~~ON HOLD until Paper~~ Publication	+	==Novel Regulators CheP and CheQ Specifically Control Chemotaxis Core Gene cheVAW Transcription in Bacterial Pathogen Campylobacter jejuni==
		+	<StructureSection load='6a51' size='340' side='right'caption='[[6a51]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6a51]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A51 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6A51 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6a51 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a51 OCA], [http://pdbe.org/6a51 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6a51 RCSB], [http://www.ebi.ac.uk/pdbsum/6a51 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6a51 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Campylobacter jejuni is the leading cause of foodborne gastrointestinal illness worldwide, and chemotaxis plays an important role in its host colonization and pathogenesis. Although many studies on chemotaxis have focused on the physical organization and signaling mechanism of the system's protein complex, much less is known about the transcriptional regulation of its components. Here, we describe two novel regulators, CJJ81176_0275 and CJJ81176_0276 (designated as CheP and CheQ), which specifically activate the transcription of the chemotaxis core genes cheV, cheA and cheW in C. jejuni and they are also essential for chemotactic responses. CheP has a single HD-related output domain (HDOD) domain and can promote CheQ binding to the cheVAW operon promoter through a protein-protein interaction. Mutagenesis analyses identified key residues critical for CheP function and/or interaction with CheQ. Further structural characterization of CheQ revealed a novel fold with strong positive surface charges that allow for its DNA binding. These findings reveal the gene regulatory mechanism of the chemotaxis system in an important bacterial pathogen and provide potential anti-virulence targets for campylobacteriosis treatment. In addition, ChePQ is an example of how proteins with the widespread but functionally obscure HDOD can coordinate with a signal output DNA-binding protein/domain to regulate the expression of important signaling pathways.

-	~~Authors: Lu, G., Gao, B~~., Cha, G., Chen, Z., Mo, R.	+	The novel regulators CheP and CheQ control the core chemotaxis operon cheVAW in Campylobacter jejuni.,Cha G, Chen Z, Mo R, Lu G, Gao B Mol Microbiol. 2019 Jan;111(1):145-158. doi: 10.1111/mmi.14144. Epub 2018 Nov 22. PMID:30338872<ref>PMID:30338872</ref>

-	~~Description~~: ~~Novel Regulators CheP and CheQ Specifically Control Chemotaxis Core Gene cheVAW Transcription in Bacterial Pathogen Campylobacter jejuni~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6a51" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Cha, G]]
	[[Category: Chen, Z]]		[[Category: Chen, Z]]
	[[Category: Gao, B]]		[[Category: Gao, B]]
-	[[Category: Cha, G]]
	[[Category: Lu, G]]		[[Category: Lu, G]]
	[[Category: Mo, R]]		[[Category: Mo, R]]
		+	[[Category: Campylobacter]]
		+	[[Category: Chemotaxis]]
		+	[[Category: Gene regulation]]
		+	[[Category: Hdod domain]]
		+	[[Category: Unknown function]]

OCA at 19:39, 9 August 2018

OCA — Thu, 09 Aug 2018 19:39:47 GMT

←Older revision		Revision as of 19:39, 9 August 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6a51 is ON HOLD	+	The entry 6a51 is ON HOLD until Paper Publication

	Authors: Lu, G., Gao, B., Cha, G., Chen, Z., Mo, R.		Authors: Lu, G., Gao, B., Cha, G., Chen, Z., Mo, R.
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	Description: Novel Regulators CheP and CheQ Specifically Control Chemotaxis Core Gene cheVAW Transcription in Bacterial Pathogen Campylobacter jejuni		Description: Novel Regulators CheP and CheQ Specifically Control Chemotaxis Core Gene cheVAW Transcription in Bacterial Pathogen Campylobacter jejuni
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Chen, Z]]
	[[Category: Gao, B]]		[[Category: Gao, B]]
	[[Category: Cha, G]]		[[Category: Cha, G]]
-	[[Category: Chen, Z]]
	[[Category: Lu, G]]		[[Category: Lu, G]]
	[[Category: Mo, R]]		[[Category: Mo, R]]

OCA: Protected "6a51" [edit=sysop:move=sysop]

OCA — Wed, 27 Jun 2018 03:55:40 GMT

Protected "6a51" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:55, 27 June 2018

OCA: New page: '''Unreleased structure''' The entry 6a51 is ON HOLD Authors: Lu, G., Gao, B., Cha, G., Chen, Z., Mo, R. Description: Novel Regulators CheP and CheQ Specifically Control Chemotaxis Cor...

OCA — Wed, 27 Jun 2018 03:55:38 GMT

New page: '''Unreleased structure''' The entry 6a51 is ON HOLD Authors: Lu, G., Gao, B., Cha, G., Chen, Z., Mo, R. Description: Novel Regulators CheP and CheQ Specifically Control Chemotaxis Cor...

New page

'''Unreleased structure'''

The entry 6a51 is ON HOLD

Authors: Lu, G., Gao, B., Cha, G., Chen, Z., Mo, R.

Description: Novel Regulators CheP and CheQ Specifically Control Chemotaxis Core Gene cheVAW Transcription in Bacterial Pathogen Campylobacter jejuni
[[Category: Unreleased Structures]]
[[Category: Gao, B]]
[[Category: Cha, G]]
[[Category: Chen, Z]]
[[Category: Lu, G]]
[[Category: Mo, R]]