6a6k - Revision history

OCA at 09:19, 22 November 2023

OCA — Wed, 22 Nov 2023 09:19:17 GMT

←Older revision		Revision as of 09:19, 22 November 2023
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	<StructureSection load='6a6k' size='340' side='right'caption='[[6a6k]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='6a6k' size='340' side='right'caption='[[6a6k]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6a6k]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A6K OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6A6K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6a6k]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A6K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6A6K FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9S6:3-[(~{E})-5-oxidanyl-2-phenyl-1-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pent-1-enyl]phenol'>9S6</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6a6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a6k OCA], [~~http~~://pdbe.org/6a6k PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6a6k RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6a6k PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6a6k ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9S6:3-[(~{E})-5-oxidanyl-2-phenyl-1-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pent-1-enyl]phenol'>9S6</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6a6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a6k OCA], [https://pdbe.org/6a6k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6a6k RCSB], [https://www.ebi.ac.uk/pdbsum/6a6k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6a6k ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ERR3_HUMAN ERR3_HUMAN]] Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity).<ref>PMID:19067653</ref> <ref>PMID:18063693</ref> <ref>PMID:11864604</ref>	+	[https://www.uniprot.org/uniprot/ERR3_HUMAN ERR3_HUMAN] Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity).<ref>PMID:19067653</ref> <ref>PMID:18063693</ref> <ref>PMID:11864604</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6a6k" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6a6k" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Estrogen-related receptor 3D structures\|Estrogen-related receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chin, J]]	+	[[Category: Chin J]]
-	[[Category: Cho~~, S J~~]]	+	[[Category: Cho SJ]]
-	[[Category: Kim, J]]	+	[[Category: Kim J]]
-	[[Category: Song, J]]	+	[[Category: Song J]]
-	[[Category: Yoon, H]]	+	[[Category: Yoon H]]
-	~~[[Category: Anaplastic thyroid cancer]]~~	+
-	~~[[Category: Estrogen-related receptor gamma]]~~	+
-	~~[[Category: Radioiodine therapy]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 07:06, 10 April 2019

OCA — Wed, 10 Apr 2019 07:06:50 GMT

←Older revision		Revision as of 07:06, 10 April 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6a6k is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Crystal structure of Estrogen-related Receptor-3 (ERR-gamma) ligand binding domain with DN201000==
		+	<StructureSection load='6a6k' size='340' side='right'caption='[[6a6k]], [[Resolution\|resolution]] 2.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6a6k]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A6K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6A6K FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9S6:3-[(~{E})-5-oxidanyl-2-phenyl-1-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pent-1-enyl]phenol'>9S6</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6a6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a6k OCA], [http://pdbe.org/6a6k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6a6k RCSB], [http://www.ebi.ac.uk/pdbsum/6a6k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6a6k ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ERR3_HUMAN ERR3_HUMAN]] Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity).<ref>PMID:19067653</ref> <ref>PMID:18063693</ref> <ref>PMID:11864604</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	An inverse agonist of estrogen-related receptor-gamma (ERRgamma), an orphan nuclear receptor encoded by E srrg, enhances sodium iodide symporter-mediated radioiodine uptake in anaplastic thyroid cancer (ATC) cells, thereby facilitating responsiveness to radioiodine therapy in vitro. We synthesized potent, selective, and orally bioavailable ERRgamma-inverse agonists and evaluated their activity by analyzing in vitro pharmacology and absorption, distribution, metabolism, excretion, and toxicity profiles. X-ray crystallographic analysis of the ligand and ERRgamma complex showed that 35 completely binds to the target protein (PDB 6A6K ). Our results showed improved radioiodine avidity in ATC cells through compound 35-mediated upregulation of iodide-handling genes, leading to enhanced responsiveness to radioiodine therapy in vitro. Importantly, in vivo (124)I-positron emission tomography/computed tomography imaging revealed that 35 increases radioiodine avidity in CAL62 tumors. Collectively, these results demonstrated that 35 can be developed as a promising treatment for ERRgamma-related cancer in the future.

-	~~Authors: Yoon~~, H., Kim, J., ~~Chin~~, J., ~~Cho~~, S~~.J.~~, ~~Song~~, J.	+	Discovery of Potent, Selective, and Orally Bioavailable Estrogen-Related Receptor-gamma Inverse Agonists To Restore the Sodium Iodide Symporter Function in Anaplastic Thyroid Cancer.,Kim J, Song J, Ji HD, Yoo EK, Lee JE, Lee SB, Oh JM, Lee S, Hwang JS, Yoon H, Kim DS, Lee SJ, Jeong M, Lee S, Kim KH, Choi HS, Lee SW, Park KG, Lee IK, Kim SH, Hwang H, Jeon YH, Chin J, Cho SJ J Med Chem. 2019 Feb 28;62(4):1837-1858. doi: 10.1021/acs.jmedchem.8b01296. Epub , 2019 Feb 4. PMID:30657313<ref>PMID:30657313</ref>

-	~~Description: Crystal structure~~ of ~~Estrogen~~-~~related Receptor~~-~~3 (ERR-gamma) ligand binding domain with DN201000~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	~~[[Category: Cho, S.J]]~~	+	<div class="pdbe-citations 6a6k" style="background-color:#fffaf0;"></div>
-	~~[[Category: Yoon, H]]~~	+	== References ==
-	~~[[Category: Song, J]]~~	+	<references/>
-	[[Category: ~~Kim, J~~]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Chin, J]]		[[Category: Chin, J]]
		+	[[Category: Cho, S J]]
		+	[[Category: Kim, J]]
		+	[[Category: Song, J]]
		+	[[Category: Yoon, H]]
		+	[[Category: Anaplastic thyroid cancer]]
		+	[[Category: Estrogen-related receptor gamma]]
		+	[[Category: Radioiodine therapy]]
		+	[[Category: Transcription]]

OCA at 05:29, 29 August 2018

OCA — Wed, 29 Aug 2018 05:29:21 GMT

←Older revision		Revision as of 05:29, 29 August 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6a6k is ON HOLD	+	The entry 6a6k is ON HOLD until Paper Publication

	Authors: Yoon, H., Kim, J., Chin, J., Cho, S.J., Song, J.		Authors: Yoon, H., Kim, J., Chin, J., Cho, S.J., Song, J.

OCA: Protected "6a6k" [edit=sysop:move=sysop]

OCA — Wed, 04 Jul 2018 05:34:40 GMT

Protected "6a6k" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:34, 4 July 2018

OCA: New page: '''Unreleased structure''' The entry 6a6k is ON HOLD Authors: Yoon, H., Kim, J., Chin, J., Cho, S.J., Song, J. Description: Crystal structure of Estrogen-related Receptor-3 (ERR-gamma)...

OCA — Wed, 04 Jul 2018 05:34:39 GMT

New page: '''Unreleased structure''' The entry 6a6k is ON HOLD Authors: Yoon, H., Kim, J., Chin, J., Cho, S.J., Song, J. Description: Crystal structure of Estrogen-related Receptor-3 (ERR-gamma)...

New page

'''Unreleased structure'''

The entry 6a6k is ON HOLD

Authors: Yoon, H., Kim, J., Chin, J., Cho, S.J., Song, J.

Description: Crystal structure of Estrogen-related Receptor-3 (ERR-gamma) ligand binding domain with DN201000
[[Category: Unreleased Structures]]
[[Category: Cho, S.J]]
[[Category: Yoon, H]]
[[Category: Song, J]]
[[Category: Kim, J]]
[[Category: Chin, J]]