6a6p - Revision history

OCA at 09:19, 22 November 2023

OCA — Wed, 22 Nov 2023 09:19:36 GMT

←Older revision		Revision as of 09:19, 22 November 2023
Line 3:		Line 3:
	<StructureSection load='6a6p' size='340' side='right'caption='[[6a6p]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='6a6p' size='340' side='right'caption='[[6a6p]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6a6p]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A6P OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6A6P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6a6p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A6P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6A6P FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9RF:{2-methyl-4-[({5-[4-(trifluoromethyl)phenyl]-1,3,4-thiadiazol-2-yl}methyl)sulfanyl]phenoxy}acetic+acid'>9RF</scene>, <scene name='pdbligand=B7G:HEPTYL-BETA-D-GLUCOPYRANOSIDE'>B7G</scene>, <scene name='pdbligand=PE3:3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL'>PE3</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6a6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a6p OCA], [~~http~~://pdbe.org/6a6p PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6a6p RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6a6p PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6a6p ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9RF:{2-methyl-4-[({5-[4-(trifluoromethyl)phenyl]-1,3,4-thiadiazol-2-yl}methyl)sulfanyl]phenoxy}acetic+acid'>9RF</scene>, <scene name='pdbligand=B7G:HEPTYL-BETA-D-GLUCOPYRANOSIDE'>B7G</scene>, <scene name='pdbligand=PE3:3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL'>PE3</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6a6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a6p OCA], [https://pdbe.org/6a6p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6a6p RCSB], [https://www.ebi.ac.uk/pdbsum/6a6p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6a6p ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PPARD_HUMAN PPARD_HUMAN]] Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.<ref>PMID:1333051</ref> <ref>PMID:15604518</ref>	+	[https://www.uniprot.org/uniprot/PPARD_HUMAN PPARD_HUMAN] Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.<ref>PMID:1333051</ref> <ref>PMID:15604518</ref>
		+
		+	==See Also==
		+	*[[Peroxisome proliferator-activated receptor 3D structures\|Peroxisome proliferator-activated receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chin~~, J W~~]]	+	[[Category: Chin JW]]
-	[[Category: Cho~~, S J~~]]	+	[[Category: Cho SJ]]
-	[[Category: Ha~~, J H~~]]	+	[[Category: Ha JH]]
-	[[Category: Song~~, J Y]]~~	+	[[Category: Song JY]]
-	~~[[Category: Complex]]~~	+
-	~~[[Category: Nuclear receptor]]~~	+
-	~~[[Category: Peroxisome proliferator-activated receptor family]]~~	+
-	~~[[Category: Ppardelta]]~~	+
-	~~[[Category: Structural protein~~]]	+

OCA at 05:38, 10 July 2019

OCA — Wed, 10 Jul 2019 05:38:20 GMT

←Older revision		Revision as of 05:38, 10 July 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6a6p is ~~ON HOLD until Paper Publication~~	+	==Crystal Structure of Peroxisome Proliferator-Activated Receptor Delta (PPARd)LBD in Complex with DN003316==
-		+	<StructureSection load='6a6p' size='340' side='right'caption='[[6a6p]], [[Resolution\|resolution]] 2.10Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6a6p]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A6P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6A6P FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9RF:{2-methyl-4-[({5-[4-(trifluoromethyl)phenyl]-1,3,4-thiadiazol-2-yl}methyl)sulfanyl]phenoxy}acetic+acid'>9RF</scene>, <scene name='pdbligand=B7G:HEPTYL-BETA-D-GLUCOPYRANOSIDE'>B7G</scene>, <scene name='pdbligand=PE3:3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL'>PE3</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6a6p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a6p OCA], [http://pdbe.org/6a6p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6a6p RCSB], [http://www.ebi.ac.uk/pdbsum/6a6p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6a6p ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PPARD_HUMAN PPARD_HUMAN]] Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.<ref>PMID:1333051</ref> <ref>PMID:15604518</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Chin, J W]]
		+	[[Category: Cho, S J]]
		+	[[Category: Ha, J H]]
		+	[[Category: Song, J Y]]
		+	[[Category: Complex]]
		+	[[Category: Nuclear receptor]]
		+	[[Category: Peroxisome proliferator-activated receptor family]]
		+	[[Category: Ppardelta]]
		+	[[Category: Structural protein]]

OCA at 18:00, 19 September 2018

OCA — Wed, 19 Sep 2018 18:00:06 GMT

←Older revision		Revision as of 18:00, 19 September 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6a6p is ON HOLD	+	The entry 6a6p is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6a6p" [edit=sysop:move=sysop]

OCA — Wed, 04 Jul 2018 05:35:03 GMT

Protected "6a6p" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:35, 4 July 2018

OCA: New page: '''Unreleased structure''' The entry 6a6p is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 04 Jul 2018 05:35:01 GMT

New page: '''Unreleased structure''' The entry 6a6p is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6a6p is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]