6agr - Revision history

OCA at 09:30, 22 November 2023

OCA — Wed, 22 Nov 2023 09:30:19 GMT

←Older revision		Revision as of 09:30, 22 November 2023
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	<StructureSection load='6agr' size='340' side='right'caption='[[6agr]], [[Resolution\|resolution]] 1.22Å' scene=''>		<StructureSection load='6agr' size='340' side='right'caption='[[6agr]], [[Resolution\|resolution]] 1.22Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6agr]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AGR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6AGR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6agr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AGR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEL:2-PHENYL-ETHANOL'>PEL</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.22Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6abn\|6abn]], [[6abz\|6abz]], [[6ac2\|6ac2]], [[6ad5\|6ad5]], [[6adf\|6adf]], [[6aea\|6aea]], [[6agn\|6agn]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEL:2-PHENYL-ETHANOL'>PEL</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6agr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6agr OCA], [https://pdbe.org/6agr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6agr RCSB], [https://www.ebi.ac.uk/pdbsum/6agr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6agr ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6agr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6agr OCA], [~~http~~://pdbe.org/6agr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6agr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6agr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6agr ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>	+	[https://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Lysozyme]]~~	+	[[Category: Seraj Z]]
-	[[Category: Seraj, Z]]	+	[[Category: Seyedarabi A]]
-	[[Category: Seyedarabi, A]]	+
-	~~[[Category: Hewl]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Phenylethyl alcohol~~]]	+

OCA at 16:04, 29 January 2020

OCA — Wed, 29 Jan 2020 16:04:49 GMT

←Older revision		Revision as of 16:04, 29 January 2020
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	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>		[[http://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Release of water is the main force which drives proteins towards crystallisation (giving rise to protein crystals for crystallography) and aggregation (main cause of neurodegenerative diseases), and as such it is possible to make changes in the crystallisation/aggregation process by using compounds which are able to reduce the amount of water molecules around proteins. Cinnamaldehyde and Phenyl ethyl alcohol are the active constituents of cinnamon and rose flower, respectively. Traditional Iranian Medicine (TIM) suggests the use of cinnamon and rose flower for the reduction of excess coldness and wetness from the brain of patients suffering from Dementia. Using crystallisation as a model system and X-ray crystallography, we tested whether Cinnamaldehyde or Phenyl ethyl alcohol can mimic the role of precipitants resulting in the formation of crystals of HEWL (as a model protein) by releasing water from the surrounding protein environment. Results have revealed that both Cinnamaldehyde and Phenyl ethyl alcohol, in particular, were capable to adequately act as 'precipitants' but in the presence of NaCl (as a salt), resulting in better crystals of HEWL by changing the amount of charge and/or making water molecules unavailable in the symmetry related position, in line with the role suggested for these compounds by TIM.
		+
		+	The role of Cinnamaldehyde and Phenyl ethyl alcohol as two types of precipitants affecting protein hydration levels.,Seraj Z, Seyedarabi A Int J Biol Macromol. 2019 Dec 27;146:705-715. doi:, 10.1016/j.ijbiomac.2019.12.204. PMID:31887389<ref>PMID:31887389</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6agr" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Lysozyme 3D structures\|Lysozyme 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:25, 14 August 2019

OCA — Wed, 14 Aug 2019 16:25:17 GMT

←Older revision		Revision as of 16:25, 14 August 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6agr is ~~ON HOLD until Paper Publication~~	+	==Structure of HEWL co-crystallised with phenylethyl alcohol==
-		+	<StructureSection load='6agr' size='340' side='right'caption='[[6agr]], [[Resolution\|resolution]] 1.22Å' scene=''>
-	~~Authors~~: ~~Seyedarabi~~, A., ~~Seraj~~, Z.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6agr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AGR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AGR FirstGlance]. <br>
-	~~Description~~: ~~Structure of HEWL co-crystallised~~ with ~~phenylethyl alcohol~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEL:2-PHENYL-ETHANOL'>PEL</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6abn\|6abn]], [[6abz\|6abz]], [[6ac2\|6ac2]], [[6ad5\|6ad5]], [[6adf\|6adf]], [[6aea\|6aea]], [[6agn\|6agn]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6agr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6agr OCA], [http://pdbe.org/6agr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6agr RCSB], [http://www.ebi.ac.uk/pdbsum/6agr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6agr ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Gallus gallus]]
		+	[[Category: Large Structures]]
		+	[[Category: Lysozyme]]
		+	[[Category: Seraj, Z]]
	[[Category: Seyedarabi, A]]		[[Category: Seyedarabi, A]]
-	[[Category: ~~Seraj, Z~~]]	+	[[Category: Hewl]]
		+	[[Category: Hydrolase]]
		+	[[Category: Phenylethyl alcohol]]

OCA at 04:58, 26 June 2019

OCA — Wed, 26 Jun 2019 04:58:30 GMT

←Older revision		Revision as of 04:58, 26 June 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6agr is ON HOLD	+	The entry 6agr is ON HOLD until Paper Publication

	Authors: Seyedarabi, A., Seraj, Z.		Authors: Seyedarabi, A., Seraj, Z.
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	Description: Structure of HEWL co-crystallised with phenylethyl alcohol		Description: Structure of HEWL co-crystallised with phenylethyl alcohol
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Seraj, Z]]
	[[Category: Seyedarabi, A]]		[[Category: Seyedarabi, A]]
		+	[[Category: Seraj, Z]]

OCA at 03:48, 12 June 2019

OCA — Wed, 12 Jun 2019 03:48:27 GMT

←Older revision		Revision as of 03:48, 12 June 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6agr is ON HOLD ~~until Paper Publication~~	+	The entry 6agr is ON HOLD

	Authors: Seyedarabi, A., Seraj, Z.		Authors: Seyedarabi, A., Seraj, Z.
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	Description: Structure of HEWL co-crystallised with phenylethyl alcohol		Description: Structure of HEWL co-crystallised with phenylethyl alcohol
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Seyedarabi, A]]
	[[Category: Seraj, Z]]		[[Category: Seraj, Z]]
		+	[[Category: Seyedarabi, A]]

OCA at 06:09, 3 October 2018

OCA — Wed, 03 Oct 2018 06:09:14 GMT

←Older revision		Revision as of 06:09, 3 October 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6agr is ON HOLD	+	The entry 6agr is ON HOLD until Paper Publication

	Authors: Seyedarabi, A., Seraj, Z.		Authors: Seyedarabi, A., Seraj, Z.

OCA: Protected "6agr" [edit=sysop:move=sysop]

OCA — Wed, 22 Aug 2018 04:35:00 GMT

Protected "6agr" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:35, 22 August 2018

OCA: New page: '''Unreleased structure''' The entry 6agr is ON HOLD Authors: Seyedarabi, A., Seraj, Z. Description: Structure of HEWL co-crystallised with phenylethyl alcohol [[Category: Unreleased S...

OCA — Wed, 22 Aug 2018 04:34:58 GMT

New page: '''Unreleased structure''' The entry 6agr is ON HOLD Authors: Seyedarabi, A., Seraj, Z. Description: Structure of HEWL co-crystallised with phenylethyl alcohol [[Category: Unreleased S...

New page

'''Unreleased structure'''

The entry 6agr is ON HOLD

Authors: Seyedarabi, A., Seraj, Z.

Description: Structure of HEWL co-crystallised with phenylethyl alcohol
[[Category: Unreleased Structures]]
[[Category: Seyedarabi, A]]
[[Category: Seraj, Z]]