6ai2 - Revision history

OCA at 09:31, 22 November 2023

OCA — Wed, 22 Nov 2023 09:31:30 GMT

←Older revision		Revision as of 09:31, 22 November 2023
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	<StructureSection load='6ai2' size='340' side='right'caption='[[6ai2]], [[Resolution\|resolution]] 3.30Å' scene=''>		<StructureSection load='6ai2' size='340' side='right'caption='[[6ai2]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ai2]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Salty Salty~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AI2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6AI2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ai2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AI2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AI2 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[3a5i\|3a5i]]</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.3Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">flhA, STM1913 ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=99287 SALTY])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ai2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ai2 OCA], [https://pdbe.org/6ai2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ai2 RCSB], [https://www.ebi.ac.uk/pdbsum/6ai2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ai2 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6ai2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ai2 OCA], [~~http~~://pdbe.org/6ai2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6ai2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6ai2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6ai2 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/FLHA_SALTY FLHA_SALTY]] Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.	+	[https://www.uniprot.org/uniprot/FLHA_SALTY FLHA_SALTY] Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6ai2" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6ai2" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Flagellar protein 3D structures\|Flagellar protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Salty~~]]	+	[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
-	[[Category: Imada, K]]	+	[[Category: Imada K]]
-	[[Category: Kinoshita, M]]	+	[[Category: Kinoshita M]]
-	[[Category: Minamino, T]]	+	[[Category: Minamino T]]
-	[[Category: Ogawa, Y]]	+	[[Category: Ogawa Y]]
-	~~[[Category: Flagellar type iii secretion]]~~	+
-	~~[[Category: Protein transport~~]]	+

OCA at 08:08, 21 May 2019

OCA — Tue, 21 May 2019 08:08:41 GMT

←Older revision		Revision as of 08:08, 21 May 2019
Line 3:		Line 3:
	<StructureSection load='6ai2' size='340' side='right'caption='[[6ai2]], [[Resolution\|resolution]] 3.30Å' scene=''>		<StructureSection load='6ai2' size='340' side='right'caption='[[6ai2]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ai2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AI2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AI2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ai2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Salty Salty]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AI2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AI2 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3a5i\|3a5i]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3a5i\|3a5i]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">flhA, STM1913 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=99287 SALTY])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ai2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ai2 OCA], [http://pdbe.org/6ai2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ai2 RCSB], [http://www.ebi.ac.uk/pdbsum/6ai2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ai2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ai2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ai2 OCA], [http://pdbe.org/6ai2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ai2 RCSB], [http://www.ebi.ac.uk/pdbsum/6ai2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ai2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/FLHA_SALTY FLHA_SALTY]] Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.		[[http://www.uniprot.org/uniprot/FLHA_SALTY FLHA_SALTY]] Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bacteria use a type III protein export apparatus for construction of the flagellum, which consists of the basal body, the hook, and the filament. FlhA forms a homo-nonamer through its C-terminal cytoplasmic domains (FlhAC) and ensures the strict order of flagellar assembly. FlhAC goes through dynamic domain motions during protein export, but it remains unknown how it occurs. Here, we report that the FlhA(G368C) mutation biases FlhAC toward a closed form, thereby reducing the binding affinity of FlhAC for flagellar export chaperones in complex with their cognate filament-type substrates. The G368C mutations also restrict the conformational flexibility of a linker region of FlhA (FlhAL), suppressing FlhAC ring formation. We propose that interactions of FlhAL with its neighboring subunit converts FlhAC in the ring from a closed conformation to an open one, allowing the chaperon/substrate complexes to bind to the FlhAC ring to form the filament at the hook tip.
		+
		+	Structural Insights into the Substrate Specificity Switch Mechanism of the Type III Protein Export Apparatus.,Inoue Y, Ogawa Y, Kinoshita M, Terahara N, Shimada M, Kodera N, Ando T, Namba K, Kitao A, Imada K, Minamino T Structure. 2019 Apr 16. pii: S0969-2126(19)30095-4. doi:, 10.1016/j.str.2019.03.017. PMID:31031200<ref>PMID:31031200</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6ai2" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Salty]]
	[[Category: Imada, K]]		[[Category: Imada, K]]
	[[Category: Kinoshita, M]]		[[Category: Kinoshita, M]]

OCA at 07:44, 20 March 2019

OCA — Wed, 20 Mar 2019 07:44:28 GMT

←Older revision		Revision as of 07:44, 20 March 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6ai2 is ~~ON HOLD~~	+	==Structure of the 328-692 fragment of FlhA (F459A)==
-		+	<StructureSection load='6ai2' size='340' side='right'caption='[[6ai2]], [[Resolution\|resolution]] 3.30Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6ai2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AI2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AI2 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3a5i\|3a5i]]</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ai2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ai2 OCA], [http://pdbe.org/6ai2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ai2 RCSB], [http://www.ebi.ac.uk/pdbsum/6ai2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ai2 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FLHA_SALTY FLHA_SALTY]] Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Imada, K]]
		+	[[Category: Kinoshita, M]]
		+	[[Category: Minamino, T]]
		+	[[Category: Ogawa, Y]]
		+	[[Category: Flagellar type iii secretion]]
		+	[[Category: Protein transport]]

OCA: Protected "6ai2" [edit=sysop:move=sysop]

OCA — Wed, 29 Aug 2018 05:34:10 GMT

Protected "6ai2" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:34, 29 August 2018

OCA: New page: '''Unreleased structure''' The entry 6ai2 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 29 Aug 2018 05:34:09 GMT

New page: '''Unreleased structure''' The entry 6ai2 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6ai2 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]