6ajl - Revision history

OCA at 09:32, 22 November 2023

OCA — Wed, 22 Nov 2023 09:32:58 GMT

←Older revision		Revision as of 09:32, 22 November 2023
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	<StructureSection load='6ajl' size='340' side='right'caption='[[6ajl]], [[Resolution\|resolution]] 3.23Å' scene=''>		<StructureSection load='6ajl' size='340' side='right'caption='[[6ajl]], [[Resolution\|resolution]] 3.23Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ajl]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AJL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6AJL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ajl]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AJL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AJL FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[6aj4\|6aj4]]</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.23Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">DOCK7, KIAA1771 ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN]), CDC42 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ajl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ajl OCA], [https://pdbe.org/6ajl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ajl RCSB], [https://www.ebi.ac.uk/pdbsum/6ajl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ajl ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6ajl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ajl OCA], [~~http~~://pdbe.org/6ajl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6ajl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6ajl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6ajl ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/DOCK7_HUMAN DOCK7_HUMAN]] Early-onset epileptic encephalopathy-cortical blindness-intellectual disability-facial dysmorphism syndrome. The disease is caused by mutations affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/DOCK7_HUMAN DOCK7_HUMAN] Early-onset epileptic encephalopathy-cortical blindness-intellectual disability-facial dysmorphism syndrome. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/DOCK7_HUMAN DOCK7_HUMAN]] Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity).[UniProtKB:Q8R1A4]<ref>PMID:16982419</ref> [[http://www.uniprot.org/uniprot/CDC42_HUMAN CDC42_HUMAN]] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.<ref>PMID:14978216</ref> <ref>PMID:15642749</ref> <ref>PMID:17038317</ref>	+	[https://www.uniprot.org/uniprot/DOCK7_HUMAN DOCK7_HUMAN] Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity).[UniProtKB:Q8R1A4]<ref>PMID:16982419</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6ajl" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6ajl" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Dedicator of cytokinesis protein 3D structures\|Dedicator of cytokinesis protein 3D structures]]
		+	*[[GTP-binding protein 3D structures\|GTP-binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kukimoto-Niino, M]]	+	[[Category: Kukimoto-Niino M]]
-	[[Category: Shirouzu, M]]	+	[[Category: Shirouzu M]]
-	~~[[Category: Cdc42]]~~	+
-	~~[[Category: Dhr-2]]~~	+
-	~~[[Category: Dock]]~~	+
-	~~[[Category: Gef]]~~	+
-	~~[[Category: Gtpase]]~~	+
-	~~[[Category: Mutant]]~~	+
-	~~[[Category: Rac]]~~	+
-	~~[[Category: Rho]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 08:07, 3 April 2019

OCA — Wed, 03 Apr 2019 08:07:59 GMT

←Older revision		Revision as of 08:07, 3 April 2019
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	<StructureSection load='6ajl' size='340' side='right'caption='[[6ajl]], [[Resolution\|resolution]] 3.23Å' scene=''>		<StructureSection load='6ajl' size='340' side='right'caption='[[6ajl]], [[Resolution\|resolution]] 3.23Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ajl]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AJL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AJL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ajl]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AJL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AJL FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6aj4\|6aj4]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6aj4\|6aj4]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DOCK7, KIAA1771 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), CDC42 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ajl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ajl OCA], [http://pdbe.org/6ajl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ajl RCSB], [http://www.ebi.ac.uk/pdbsum/6ajl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ajl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ajl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ajl OCA], [http://pdbe.org/6ajl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ajl RCSB], [http://www.ebi.ac.uk/pdbsum/6ajl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ajl ProSAT]</span></td></tr>
	</table>		</table>
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	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/DOCK7_HUMAN DOCK7_HUMAN]] Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity).[UniProtKB:Q8R1A4]<ref>PMID:16982419</ref> [[http://www.uniprot.org/uniprot/CDC42_HUMAN CDC42_HUMAN]] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.<ref>PMID:14978216</ref> <ref>PMID:15642749</ref> <ref>PMID:17038317</ref>		[[http://www.uniprot.org/uniprot/DOCK7_HUMAN DOCK7_HUMAN]] Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity).[UniProtKB:Q8R1A4]<ref>PMID:16982419</ref> [[http://www.uniprot.org/uniprot/CDC42_HUMAN CDC42_HUMAN]] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.<ref>PMID:14978216</ref> <ref>PMID:15642749</ref> <ref>PMID:17038317</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Dedicator Of CytoKinesis (DOCK) family of atypical guanine nucleotide exchange factors activates the Rho family GTPases Rac and/or Cdc42 through DOCK homology region 2 (DHR-2). Previous structural analyses of the DHR-2 domains of DOCK2 and DOCK9 have shown that they preferentially bind Rac1 and Cdc42, respectively; however, the molecular mechanism by which DHR-2 distinguishes between these GTPases is unclear. Here we report the crystal structure of the Cdc42-bound form of the DOCK7 DHR-2 domain showing dual specificity for Rac1 and Cdc42. The structure revealed increased substrate tolerance of DOCK7 at the interfaces with switch 1 and residue 56 of Cdc42. Furthermore, molecular dynamics simulations showed a closed-to-open conformational change in the DOCK7 DHR-2 domain between the Cdc42- and Rac1-bound states by lobe B displacement. Our results suggest that lobe B acts as a sensor for identifying different switch 1 conformations and explain how DOCK7 recognizes both Rac1 and Cdc42.
		+
		+	Structural Basis for the Dual Substrate Specificity of DOCK7 Guanine Nucleotide Exchange Factor.,Kukimoto-Niino M, Tsuda K, Ihara K, Mishima-Tsumagari C, Honda K, Ohsawa N, Shirouzu M Structure. 2019 Feb 16. pii: S0969-2126(19)30045-0. doi:, 10.1016/j.str.2019.02.001. PMID:30853411<ref>PMID:30853411</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6ajl" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Kukimoto-Niino, M]]		[[Category: Kukimoto-Niino, M]]

OCA at 07:45, 20 March 2019

OCA — Wed, 20 Mar 2019 07:45:15 GMT

←Older revision		Revision as of 07:45, 20 March 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6ajl is ~~ON HOLD until Paper Publication~~	+	==DOCK7 mutant I1836Y complexed with Cdc42==
-		+	<StructureSection load='6ajl' size='340' side='right'caption='[[6ajl]], [[Resolution\|resolution]] 3.23Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6ajl]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AJL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AJL FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6aj4\|6aj4]]</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ajl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ajl OCA], [http://pdbe.org/6ajl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ajl RCSB], [http://www.ebi.ac.uk/pdbsum/6ajl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ajl ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/DOCK7_HUMAN DOCK7_HUMAN]] Early-onset epileptic encephalopathy-cortical blindness-intellectual disability-facial dysmorphism syndrome. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DOCK7_HUMAN DOCK7_HUMAN]] Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity).[UniProtKB:Q8R1A4]<ref>PMID:16982419</ref> [[http://www.uniprot.org/uniprot/CDC42_HUMAN CDC42_HUMAN]] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.<ref>PMID:14978216</ref> <ref>PMID:15642749</ref> <ref>PMID:17038317</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Kukimoto-Niino, M]]
		+	[[Category: Shirouzu, M]]
		+	[[Category: Cdc42]]
		+	[[Category: Dhr-2]]
		+	[[Category: Dock]]
		+	[[Category: Gef]]
		+	[[Category: Gtpase]]
		+	[[Category: Mutant]]
		+	[[Category: Rac]]
		+	[[Category: Rho]]
		+	[[Category: Signaling protein]]

OCA at 06:07, 10 October 2018

OCA — Wed, 10 Oct 2018 06:07:54 GMT

←Older revision		Revision as of 06:07, 10 October 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6ajl is ON HOLD	+	The entry 6ajl is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6ajl" [edit=sysop:move=sysop]

OCA — Wed, 05 Sep 2018 08:37:49 GMT

Protected "6ajl" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:37, 5 September 2018

OCA: New page: '''Unreleased structure''' The entry 6ajl is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 05 Sep 2018 08:37:47 GMT

New page: '''Unreleased structure''' The entry 6ajl is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6ajl is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]