6al4 - Revision history

OCA at 14:19, 4 October 2023

OCA — Wed, 04 Oct 2023 14:19:54 GMT

←Older revision		Revision as of 14:19, 4 October 2023
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	==CRYSTAL STRUCTURE OF ANTI-CD19 ANTIBODY B43 FAB==		==CRYSTAL STRUCTURE OF ANTI-CD19 ANTIBODY B43 FAB==
-	<StructureSection load='6al4' size='340' side='right' caption='[[6al4]], [[Resolution\|resolution]] 2.45Å' scene=''>	+	<StructureSection load='6al4' size='340' side='right'caption='[[6al4]], [[Resolution\|resolution]] 2.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6al4]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AL4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6AL4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6al4]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AL4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AL4 FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.45Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~IGK@ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN]), IGH@ ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6al4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6al4 OCA], [~~http~~://pdbe.org/6al4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6al4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6al4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6al4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6al4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6al4 OCA], [https://pdbe.org/6al4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6al4 RCSB], [https://www.ebi.ac.uk/pdbsum/6al4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6al4 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q6P5S8_HUMAN Q6P5S8_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6al4" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6al4" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Gilliland, G L~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Obmolova, G~~]]	+	[[Category: Gilliland GL]]
-	[[Category: ~~Teplyakov, A~~]]	+	[[Category: Obmolova G]]
-	[[Category: ~~Immune system~~]]	+	[[Category: Teplyakov A]]

OCA at 08:29, 2 May 2018

OCA — Wed, 02 May 2018 08:29:18 GMT

←Older revision		Revision as of 08:29, 2 May 2018
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	<StructureSection load='6al4' size='340' side='right' caption='[[6al4]], [[Resolution\|resolution]] 2.45Å' scene=''>		<StructureSection load='6al4' size='340' side='right' caption='[[6al4]], [[Resolution\|resolution]] 2.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6al4]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AL4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AL4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6al4]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AL4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AL4 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IGK@ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), IGH@ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6al4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6al4 OCA], [http://pdbe.org/6al4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6al4 RCSB], [http://www.ebi.ac.uk/pdbsum/6al4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6al4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6al4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6al4 OCA], [http://pdbe.org/6al4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6al4 RCSB], [http://www.ebi.ac.uk/pdbsum/6al4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6al4 ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Gilliland, G L]]		[[Category: Gilliland, G L]]
	[[Category: Obmolova, G]]		[[Category: Obmolova, G]]
	[[Category: Teplyakov, A]]		[[Category: Teplyakov, A]]
	[[Category: Immune system]]		[[Category: Immune system]]

OCA at 06:36, 28 March 2018

OCA — Wed, 28 Mar 2018 06:36:16 GMT

←Older revision		Revision as of 06:36, 28 March 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6al4 is ~~ON HOLD until Paper~~ Publication	+	==CRYSTAL STRUCTURE OF ANTI-CD19 ANTIBODY B43 FAB==
		+	<StructureSection load='6al4' size='340' side='right' caption='[[6al4]], [[Resolution\|resolution]] 2.45Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6al4]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AL4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AL4 FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6al4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6al4 OCA], [http://pdbe.org/6al4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6al4 RCSB], [http://www.ebi.ac.uk/pdbsum/6al4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6al4 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	CD19 is a transmembrane protein expressed on malignant B cells, but not in other lineages or other tissues, which makes it an attractive target for monoclonal antibody-mediated immunotherapy. Anti-CD19 antibody B43 was utilized in a bispecific T-cell engager (BiTE) blinatumomab that demonstrated potency for the treatment of relapsed acute lymphoblastic leukemia. To gain insight into the mechanism of action of the antibody, the crystal structure of B43 Fab was determined in complex with CD19 and in the unbound form. The structure revealed the binding epitope, explained the lack of cross-reactivity toward non-human species, and suggested the key-and-lock mechanism of antigen recognition. Most unexpectedly, the structure revealed a unique molecular topology of CD19. Rather than a tandem of c-type immunoglobulin folds predicted from the amino acid sequence, the extracellular domain of CD19 exhibits an elongated beta-sandwich formed by two immunoglobulin folds by swapping their C-terminal halves. This is the first structure of CD19, which has no sequence homologs.

-	~~Authors~~:	+	Crystal structure of B-cell co-receptor CD19 in complex with antibody B43 reveals an unexpected fold.,Teplyakov A, Obmolova G, Luo J, Gilliland GL Proteins. 2018 Feb 28. doi: 10.1002/prot.25485. PMID:29490423<ref>PMID:29490423</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 6al4" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Gilliland, G L]]
		+	[[Category: Obmolova, G]]
		+	[[Category: Teplyakov, A]]
		+	[[Category: Immune system]]

OCA: Protected "6al4" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2017 16:32:10 GMT

Protected "6al4" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:32, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 6al4 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

OCA — Wed, 27 Sep 2017 16:32:09 GMT

New page: '''Unreleased structure''' The entry 6al4 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6al4 is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]