6aoh - Revision history

OCA at 14:21, 4 October 2023

OCA — Wed, 04 Oct 2023 14:21:51 GMT

←Older revision		Revision as of 14:21, 4 October 2023
Line 3:		Line 3:
	<StructureSection load='6aoh' size='340' side='right'caption='[[6aoh]], [[Resolution\|resolution]] 3.50Å' scene=''>		<StructureSection load='6aoh' size='340' side='right'caption='[[6aoh]], [[Resolution\|resolution]] 3.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6aoh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AOH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6AOH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6aoh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AOH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AOH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOD:5-{4-[3-(2-methoxypyrimidin-5-yl)phenyl]piperazin-1-yl}pyrimidine-2,4-diamine'>BOD</scene>, <scene name='pdbligand=CB3:10-PROPARGYL-5,8-DIDEAZAFOLIC+ACID'>CB3</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.5Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6aog\|6aog]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOD:5-{4-[3-(2-methoxypyrimidin-5-yl)phenyl]piperazin-1-yl}pyrimidine-2,4-diamine'>BOD</scene>, <scene name='pdbligand=CB3:10-PROPARGYL-5,8-DIDEAZAFOLIC+ACID'>CB3</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6aoh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aoh OCA], [~~http~~://pdbe.org/6aoh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6aoh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6aoh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6aoh ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6aoh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aoh OCA], [https://pdbe.org/6aoh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6aoh RCSB], [https://www.ebi.ac.uk/pdbsum/6aoh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6aoh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/DRTS_TOXGO DRTS_TOXGO]] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity).	+	[https://www.uniprot.org/uniprot/DRTS_TOXGO DRTS_TOXGO] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity).

	==See Also==		==See Also==
Line 16:		Line 16:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chen, Z]]
-	[[Category: Li, Y]]
-	[[Category: Lu, H]]
-	[[Category: Thomas, S B]]
-	[[Category: Dhfr]]
-	[[Category: Oxidoreductase]]
-	[[Category: Pyrimethamine]]
	[[Category: Toxoplasma gondii]]		[[Category: Toxoplasma gondii]]
		+	[[Category: Chen Z]]
		+	[[Category: Li Y]]
		+	[[Category: Lu H]]
		+	[[Category: Thomas SB]]

OCA at 21:29, 28 October 2020

OCA — Wed, 28 Oct 2020 21:29:49 GMT

←Older revision		Revision as of 21:29, 28 October 2020
Line 1:		Line 1:

	==Crystal structure of Toxoplasma gondii TS-DHFR complexed with NADPH, dUMP, PDDF, and 5-(4-(3-(2-methoxypyrimidin-5-yl)phenyl)piperazin-1-yl)pyrimidine-2,4-diamine (TRC-2533)==		==Crystal structure of Toxoplasma gondii TS-DHFR complexed with NADPH, dUMP, PDDF, and 5-(4-(3-(2-methoxypyrimidin-5-yl)phenyl)piperazin-1-yl)pyrimidine-2,4-diamine (TRC-2533)==
-	<StructureSection load='6aoh' size='340' side='right' caption='[[6aoh]], [[Resolution\|resolution]] 3.50Å' scene=''>	+	<StructureSection load='6aoh' size='340' side='right'caption='[[6aoh]], [[Resolution\|resolution]] 3.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6aoh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AOH OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6AOH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6aoh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AOH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6AOH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOD:5-{4-[3-(2-methoxypyrimidin-5-yl)phenyl]piperazin-1-yl}pyrimidine-2,4-diamine'>BOD</scene>, <scene name='pdbligand=CB3:10-PROPARGYL-5,8-DIDEAZAFOLIC+ACID'>CB3</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOD:5-{4-[3-(2-methoxypyrimidin-5-yl)phenyl]piperazin-1-yl}pyrimidine-2,4-diamine'>BOD</scene>, <scene name='pdbligand=CB3:10-PROPARGYL-5,8-DIDEAZAFOLIC+ACID'>CB3</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6aog\|6aog]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6aog\|6aog]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6aoh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aoh OCA], [http://pdbe.org/6aoh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6aoh RCSB], [http://www.ebi.ac.uk/pdbsum/6aoh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6aoh ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6aoh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aoh OCA], [http://pdbe.org/6aoh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6aoh RCSB], [http://www.ebi.ac.uk/pdbsum/6aoh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6aoh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/DRTS_TOXGO DRTS_TOXGO]] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity).		[[http://www.uniprot.org/uniprot/DRTS_TOXGO DRTS_TOXGO]] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity).
		+
		+	==See Also==
		+	*[[Dihydrofolate reductase 3D structures\|Dihydrofolate reductase 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Chen, Z]]		[[Category: Chen, Z]]
	[[Category: Li, Y]]		[[Category: Li, Y]]

OCA at 06:03, 22 August 2018

OCA — Wed, 22 Aug 2018 06:03:06 GMT

←Older revision		Revision as of 06:03, 22 August 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 6aoh is ON HOLD until Paper Publication~~	+	==Crystal structure of Toxoplasma gondii TS-DHFR complexed with NADPH, dUMP, PDDF, and 5-(4-(3-(2-methoxypyrimidin-5-yl)phenyl)piperazin-1-yl)pyrimidine-2,4-diamine (TRC-2533)==
-		+	<StructureSection load='6aoh' size='340' side='right' caption='[[6aoh]], [[Resolution\|resolution]] 3.50Å' scene=''>
-	~~Authors: Thomas, S.B., Li, Y., Chen, Z., Lu, H.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6aoh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AOH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AOH FirstGlance]. <br>
-	~~Description:~~ Crystal structure of Toxoplasma gondii TS-DHFR complexed with NADPH, dUMP, PDDF, and 5-(4-(3-(2-methoxypyrimidin-5-yl)phenyl)piperazin-1-yl)pyrimidine-2,4-diamine (TRC-2533)	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOD:5-{4-[3-(2-methoxypyrimidin-5-yl)phenyl]piperazin-1-yl}pyrimidine-2,4-diamine'>BOD</scene>, <scene name='pdbligand=CB3:10-PROPARGYL-5,8-DIDEAZAFOLIC+ACID'>CB3</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6aog\|6aog]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6aoh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aoh OCA], [http://pdbe.org/6aoh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6aoh RCSB], [http://www.ebi.ac.uk/pdbsum/6aoh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6aoh ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DRTS_TOXGO DRTS_TOXGO]] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity).
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Chen, Z]]
	[[Category: Li, Y]]		[[Category: Li, Y]]
	[[Category: Lu, H]]		[[Category: Lu, H]]
-	[[Category: ~~Chen~~, Z]]	+	[[Category: Thomas, S B]]
-	[[Category: ~~Thomas, S.B~~]]	+	[[Category: Dhfr]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Pyrimethamine]]
		+	[[Category: Toxoplasma gondii]]

OCA: Protected "6aoh" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2017 16:37:11 GMT

Protected "6aoh" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:37, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 6aoh is ON HOLD until Paper Publication Authors: Thomas, S.B., Li, Y., Chen, Z., Lu, H. Description: Crystal structure of Toxoplasma gondii TS-DHFR...

OCA — Wed, 27 Sep 2017 16:37:10 GMT

New page: '''Unreleased structure''' The entry 6aoh is ON HOLD until Paper Publication Authors: Thomas, S.B., Li, Y., Chen, Z., Lu, H. Description: Crystal structure of Toxoplasma gondii TS-DHFR...

New page

'''Unreleased structure'''

The entry 6aoh is ON HOLD until Paper Publication

Authors: Thomas, S.B., Li, Y., Chen, Z., Lu, H.

Description: Crystal structure of Toxoplasma gondii TS-DHFR complexed with NADPH, dUMP, PDDF, and 5-(4-(3-(2-methoxypyrimidin-5-yl)phenyl)piperazin-1-yl)pyrimidine-2,4-diamine (TRC-2533)
[[Category: Unreleased Structures]]
[[Category: Li, Y]]
[[Category: Lu, H]]
[[Category: Chen, Z]]
[[Category: Thomas, S.B]]