6atu - Revision history

OCA at 14:24, 4 October 2023

OCA — Wed, 04 Oct 2023 14:24:52 GMT

←Older revision		Revision as of 14:24, 4 October 2023
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	==Exploring Cystine Dense Peptide Space to Open a Unique Molecular Toolbox==		==Exploring Cystine Dense Peptide Space to Open a Unique Molecular Toolbox==
-	<StructureSection load='6atu' size='340' side='right' caption='[[6atu]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='6atu' size='340' side='right'caption='[[6atu]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6atu]] is a 18 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ATU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6ATU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6atu]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ATU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ATU FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[6atl\|6atl]], [[6atm\|6atm]], [[6atn\|6atn]], [[6ats\|6ats]]</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">PI3, WAP3, WFDC14 ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6atu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6atu OCA], [https://pdbe.org/6atu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6atu RCSB], [https://www.ebi.ac.uk/pdbsum/6atu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6atu ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6atu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6atu OCA], [~~http~~://pdbe.org/6atu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6atu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6atu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6atu ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ELAF_HUMAN ELAF_HUMAN]] Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis.	+	[https://www.uniprot.org/uniprot/ELAF_HUMAN ELAF_HUMAN] Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Gewe, M M~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Rupert, P~~]]	+	[[Category: Gewe MM]]
-	[[Category: ~~Strong, R K~~]]	+	[[Category: Rupert P]]
-	[[Category: ~~Cystine knot]]~~	+	[[Category: Strong RK]]
-	~~[[Category: Knottin]]~~	+
-	~~[[Category: Toxin~~]]	+

OCA at 06:59, 14 March 2018

OCA — Wed, 14 Mar 2018 06:59:55 GMT

←Older revision		Revision as of 06:59, 14 March 2018
Line 3:		Line 3:
	<StructureSection load='6atu' size='340' side='right' caption='[[6atu]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='6atu' size='340' side='right' caption='[[6atu]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6atu]] is a 18 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ATU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ATU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6atu]] is a 18 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ATU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ATU FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6atl\|6atl]], [[6atm\|6atm]], [[6atn\|6atn]], [[6ats\|6ats]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6atl\|6atl]], [[6atm\|6atm]], [[6atn\|6atn]], [[6ats\|6ats]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PI3, WAP3, WFDC14 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6atu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6atu OCA], [http://pdbe.org/6atu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6atu RCSB], [http://www.ebi.ac.uk/pdbsum/6atu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6atu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6atu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6atu OCA], [http://pdbe.org/6atu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6atu RCSB], [http://www.ebi.ac.uk/pdbsum/6atu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6atu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/ELAF_HUMAN ELAF_HUMAN]] Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis.		[[http://www.uniprot.org/uniprot/ELAF_HUMAN ELAF_HUMAN]] Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Peptides folded through interwoven disulfides display extreme biochemical properties and unique medicinal potential. However, their exploitation has been hampered by the limited amounts isolatable from natural sources and the expense of chemical synthesis. We developed reliable biological methods for high-throughput expression, screening and large-scale production of these peptides: 46 were successfully produced in multimilligram quantities, and >600 more were deemed expressible through stringent screening criteria. Many showed extreme resistance to temperature, proteolysis and/or reduction, and all displayed inhibitory activity against at least 1 of 20 ion channels tested, thus confirming their biological functionality. Crystal structures of 12 confirmed proper cystine topology and the utility of crystallography to study these molecules but also highlighted the need for rational classification. Previous categorization attempts have focused on limited subsets featuring distinct motifs. Here we present a global definition, classification and analysis of >700 structures of cystine-dense peptides, providing a unifying framework for these molecules.
		+
		+	Screening, large-scale production and structure-based classification of cystine-dense peptides.,Correnti CE, Gewe MM, Mehlin C, Bandaranayake AD, Johnsen WA, Rupert PB, Brusniak MY, Clarke M, Burke SE, De Van Der Schueren W, Pilat K, Turnbaugh SM, May D, Watson A, Chan MK, Bahl CD, Olson JM, Strong RK Nat Struct Mol Biol. 2018 Mar;25(3):270-278. doi: 10.1038/s41594-018-0033-9. Epub, 2018 Feb 26. PMID:29483648<ref>PMID:29483648</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6atu" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Gewe, M M]]		[[Category: Gewe, M M]]
	[[Category: Rupert, P]]		[[Category: Rupert, P]]

OCA at 06:29, 28 February 2018

OCA — Wed, 28 Feb 2018 06:29:29 GMT

←Older revision		Revision as of 06:29, 28 February 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 6atu is ON HOLD until Paper Publication~~	+	==Exploring Cystine Dense Peptide Space to Open a Unique Molecular Toolbox==
-		+	<StructureSection load='6atu' size='340' side='right' caption='[[6atu]], [[Resolution\|resolution]] 2.40Å' scene=''>
-	~~Authors: Gewe, M.M., Rupert, P., Strong, R.K.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6atu]] is a 18 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ATU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ATU FirstGlance]. <br>
-	~~Description:~~ Exploring Cystine Dense Peptide Space to Open a Unique Molecular Toolbox	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6atl\|6atl]], [[6atm\|6atm]], [[6atn\|6atn]], [[6ats\|6ats]]</td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6atu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6atu OCA], [http://pdbe.org/6atu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6atu RCSB], [http://www.ebi.ac.uk/pdbsum/6atu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6atu ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Strong~~, R.K]]	+	</table>
-	[[Category: Gewe, M.M]]	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ELAF_HUMAN ELAF_HUMAN]] Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Gewe, M M]]
	[[Category: Rupert, P]]		[[Category: Rupert, P]]
		+	[[Category: Strong, R K]]
		+	[[Category: Cystine knot]]
		+	[[Category: Knottin]]
		+	[[Category: Toxin]]

OCA: Protected "6atu" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2017 16:47:03 GMT

Protected "6atu" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:47, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 6atu is ON HOLD until Paper Publication Authors: Gewe, M.M., Rupert, P., Strong, R.K. Description: Exploring Cystine Dense Peptide Space to Open a ...

OCA — Wed, 27 Sep 2017 16:47:02 GMT

New page: '''Unreleased structure''' The entry 6atu is ON HOLD until Paper Publication Authors: Gewe, M.M., Rupert, P., Strong, R.K. Description: Exploring Cystine Dense Peptide Space to Open a ...

New page

'''Unreleased structure'''

The entry 6atu is ON HOLD until Paper Publication

Authors: Gewe, M.M., Rupert, P., Strong, R.K.

Description: Exploring Cystine Dense Peptide Space to Open a Unique Molecular Toolbox
[[Category: Unreleased Structures]]
[[Category: Strong, R.K]]
[[Category: Gewe, M.M]]
[[Category: Rupert, P]]