6auj - Revision history

OCA at 14:25, 4 October 2023

OCA — Wed, 04 Oct 2023 14:25:25 GMT

←Older revision		Revision as of 14:25, 4 October 2023
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	==Crystal structure of thymidylate synthase from Elizabethkingia anophelis NUHP1==		==Crystal structure of thymidylate synthase from Elizabethkingia anophelis NUHP1==
-	<StructureSection load='6auj' size='340' side='right' caption='[[6auj]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='6auj' size='340' side='right'caption='[[6auj]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6auj]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Elizabethkingia_anophelis_nuhp1~~ Elizabethkingia anophelis ~~nuhp1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AUJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6AUJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6auj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Elizabethkingia_anophelis_NUHP1 Elizabethkingia anophelis NUHP1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AUJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AUJ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=M0H:S-(HYDROXYMETHYL)-L-CYSTEINE'>M0H</scene>~~</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M0H:S-(HYDROXYMETHYL)-L-CYSTEINE'>M0H</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">thyA~~, ~~BD94_0762 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1338011 Elizabethkingia anophelis NUHP1])~~<~~/td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6auj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6auj OCA], [https://pdbe.org/6auj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6auj RCSB], [https://www.ebi.ac.uk/pdbsum/6auj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6auj ProSAT]</span></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45]~~ </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6auj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6auj OCA], [~~http~~://pdbe.org/6auj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6auj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6auj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6auj ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/A0A077EAN3_9FLAO A0A077EAN3_9FLAO]] Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.[HAMAP-Rule:MF_00008]	+	[https://www.uniprot.org/uniprot/A0A077EAN3_9FLAO A0A077EAN3_9FLAO] Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.[HAMAP-Rule:MF_00008]
		+
		+	==See Also==
		+	*[[Thymidylate synthase 3D structures\|Thymidylate synthase 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Elizabethkingia anophelis ~~nuhp1~~]]	+	[[Category: Elizabethkingia anophelis NUHP1]]
-	[[Category: ~~Thymidylate synthase]]~~	+	[[Category: Large Structures]]
-	~~[[Category: Structural genomic]]~~	+
-	~~[[Category: Elizabethkingia anopheli]]~~	+
-	~~[[Category: Ssgcid]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA: Protected "6auj" [edit=sysop:move=sysop]

OCA — Mon, 06 Nov 2017 11:50:33 GMT

Protected "6auj" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:50, 6 November 2017

OCA: New page: ==Crystal structure of thymidylate synthase from Elizabethkingia anophelis NUHP1== == Structural highlights ==
<table><tr><td colspan='2'>[[6auj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Elizabethkingia_anophelis_nuhp1 Elizabethkingia anophelis nuhp1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AUJ OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AUJ FirstGlance]. 
</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=M0H:S-(HYDROXYMETHYL)-L-CYSTEINE'>M0H</scene></td></tr>
<tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">thyA, BD94_0762 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1338011 Elizabethkingia anophelis NUHP1])</td></tr>
<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </td></tr>
<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6auj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6auj OCA], [http://pdbe.org/6auj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6auj RCSB], [http://www.ebi.ac.uk/pdbsum/6auj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6auj ProSAT]</td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/A0A077EAN3_9FLAO A0A077EAN3_9FLAO]] Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.[HAMAP-Rule:MF_00008]
TOC
</StructureSection>
[[Category: Elizabethkingia anophelis nuhp1]]
[[Category: Thymidylate synthase]]
[[Category: Structural genomic]]
[[Category: Elizabethkingia anopheli]]
[[Category: Ssgcid]]
[[Category: Transferase]]