6auo - Revision history

OCA at 14:25, 4 October 2023

OCA — Wed, 04 Oct 2023 14:25:36 GMT

←Older revision		Revision as of 14:25, 4 October 2023
Line 3:		Line 3:
	<StructureSection load='6auo' size='340' side='right'caption='[[6auo]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='6auo' size='340' side='right'caption='[[6auo]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6auo]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~As_4.1583 As 4.1583~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AUO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6AUO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6auo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_avidinii Streptomyces avidinii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AUO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AUO FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OL4:N-biotin-C-Co4(mu3-O)4(Py)3(H2O)4-beta-alanine'>OL4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6auo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6auo OCA], [~~http~~://pdbe.org/6auo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6auo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6auo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6auo ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OL4:N-biotin-C-Co4(mu3-O)4(Py)3(H2O)4-beta-alanine'>OL4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6auo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6auo OCA], [https://pdbe.org/6auo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6auo RCSB], [https://www.ebi.ac.uk/pdbsum/6auo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6auo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SAV_STRAV SAV_STRAV]] The biological function of streptavidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of streptavidin).	+	[https://www.uniprot.org/uniprot/SAV_STRAV SAV_STRAV] The biological function of streptavidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of streptavidin).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: As 4 1583]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Borovik~~, A S~~]]	+	[[Category: Streptomyces avidinii]]
-	[[Category: Huerta-Lavorie, R]]	+	[[Category: Borovik AS]]
-	[[Category: Nguyen~~, A I~~]]	+	[[Category: Huerta-Lavorie R]]
-	[[Category: Olshansky, L]]	+	[[Category: Nguyen AI]]
-	[[Category: Tilley~~, T D~~]]	+	[[Category: Olshansky L]]
-	[[Category: Vallapurakal, J]]	+	[[Category: Tilley TD]]
-	~~[[Category: Artificial metalloprotein]]~~	+	[[Category: Vallapurakal J]]
-	~~[[Category: Biomimetic]]~~	+
-	~~[[Category: Biotin]]~~	+
-	~~[[Category: Co4o4]]~~	+
-	~~[[Category: Metal binding protein]]~~	+
-	~~[[Category: Photosynthesis]]~~	+
-	~~[[Category: Streptavidin]]~~	+
-	~~[[Category: Water oxidation~~]]	+

OCA at 09:47, 4 December 2019

OCA — Wed, 04 Dec 2019 09:47:48 GMT

←Older revision		Revision as of 09:47, 4 December 2019
Line 1:		Line 1:

	==Artificial Metalloproteins Containing a Co4O4 Active Site - 2xm-S112F==		==Artificial Metalloproteins Containing a Co4O4 Active Site - 2xm-S112F==
-	<StructureSection load='6auo' size='340' side='right' caption='[[6auo]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='6auo' size='340' side='right'caption='[[6auo]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6auo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/As_4.1583 As 4.1583]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AUO FirstGlance]. <br>		<table><tr><td colspan='2'>[[6auo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/As_4.1583 As 4.1583]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AUO FirstGlance]. <br>
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 6auo" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6auo" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Avidin 3D structures\|Avidin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 23:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: As 4 1583]]		[[Category: As 4 1583]]
		+	[[Category: Large Structures]]
	[[Category: Borovik, A S]]		[[Category: Borovik, A S]]
	[[Category: Huerta-Lavorie, R]]		[[Category: Huerta-Lavorie, R]]

OCA at 07:00, 14 March 2018

OCA — Wed, 14 Mar 2018 07:00:26 GMT

←Older revision		Revision as of 07:00, 14 March 2018
Line 3:		Line 3:
	<StructureSection load='6auo' size='340' side='right' caption='[[6auo]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='6auo' size='340' side='right' caption='[[6auo]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6auo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AUO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6auo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/As_4.1583 As 4.1583]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AUO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OL4:N-biotin-C-Co4(mu3-O)4(Py)3(H2O)4-beta-alanine'>OL4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OL4:N-biotin-C-Co4(mu3-O)4(Py)3(H2O)4-beta-alanine'>OL4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6auo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6auo OCA], [http://pdbe.org/6auo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6auo RCSB], [http://www.ebi.ac.uk/pdbsum/6auo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6auo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6auo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6auo OCA], [http://pdbe.org/6auo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6auo RCSB], [http://www.ebi.ac.uk/pdbsum/6auo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6auo ProSAT]</span></td></tr>
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: As 4 1583]]
	[[Category: Borovik, A S]]		[[Category: Borovik, A S]]
	[[Category: Huerta-Lavorie, R]]		[[Category: Huerta-Lavorie, R]]

OCA at 06:30, 28 February 2018

OCA — Wed, 28 Feb 2018 06:30:08 GMT

←Older revision		Revision as of 06:30, 28 February 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6auo is ~~ON HOLD~~	+	==Artificial Metalloproteins Containing a Co4O4 Active Site - 2xm-S112F==
		+	<StructureSection load='6auo' size='340' side='right' caption='[[6auo]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6auo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AUO FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OL4:N-biotin-C-Co4(mu3-O)4(Py)3(H2O)4-beta-alanine'>OL4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6auo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6auo OCA], [http://pdbe.org/6auo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6auo RCSB], [http://www.ebi.ac.uk/pdbsum/6auo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6auo ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SAV_STRAV SAV_STRAV]] The biological function of streptavidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of streptavidin).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Artificial metalloproteins (ArMs) containing Co4O4 cubane active sites were constructed via biotin-streptavidin technology. Stabilized by hydrogen bonds (H-bonds), terminal and cofacial Co(III)-OH2 moieties are observed crystallographically in a series of immobilized cubane sites. Solution electrochemistry provided correlations of oxidation potential and pH. For variants containing Ser and Phe adjacent to the metallocofactor, 1e(-)/1H(+) chemistry predominates until pH 8, above which the oxidation becomes pH-independent. Installation of Tyr proximal to the Co4O4 active site provided a single H-bond to one of a set of cofacial Co(III)-OH2 groups. With this variant, multi-e(-)/multi-H(+) chemistry is observed, along with a change in mechanism at pH 9.5 that is consistent with Tyr deprotonation. With structural similarities to both the oxygen-evolving complex of photosystem II (H-bonded Tyr) and to thin film water oxidation catalysts (Co4O4 core), these findings bridge synthetic and biological systems for water oxidation, highlighting the importance of secondary sphere interactions in mediating multi-e(-)/multi-H(+) reactivity.

-	~~Authors: Olshansky~~, L~~., Vallapurakal, J.~~, Huerta-Lavorie, R., Nguyen, A~~.I.~~, Tilley, T.D.~~, Borovik, A~~.S.	+	Artificial Metalloproteins Containing Co4O4 Cubane Active Sites.,Olshansky L, Huerta-Lavorie R, Nguyen AI, Vallapurackal J, Furst A, Tilley TD, Borovik AS J Am Chem Soc. 2018 Feb 13. doi: 10.1021/jacs.7b13052. PMID:29401385<ref>PMID:29401385</ref>

-	~~Description: Artificial Metalloproteins Containing~~ a ~~Co4O4 Active Site~~ -~~2xm~~-~~S112F~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	~~[[Category: Borovik, A.S]]~~	+	<div class="pdbe-citations 6auo" style="background-color:#fffaf0;"></div>
-	~~[[Category: Vallapurakal, J]]~~	+	== References ==
-	~~[[Category: Tilley, T.D]]~~	+	<references/>
-	[[Category: ~~Nguyen~~, A.I]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Borovik, A S]]
	[[Category: Huerta-Lavorie, R]]		[[Category: Huerta-Lavorie, R]]
		+	[[Category: Nguyen, A I]]
	[[Category: Olshansky, L]]		[[Category: Olshansky, L]]
		+	[[Category: Tilley, T D]]
		+	[[Category: Vallapurakal, J]]
		+	[[Category: Artificial metalloprotein]]
		+	[[Category: Biomimetic]]
		+	[[Category: Biotin]]
		+	[[Category: Co4o4]]
		+	[[Category: Metal binding protein]]
		+	[[Category: Photosynthesis]]
		+	[[Category: Streptavidin]]
		+	[[Category: Water oxidation]]

OCA: Protected "6auo" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2017 16:49:04 GMT

Protected "6auo" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:49, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 6auo is ON HOLD Authors: Olshansky, L., Vallapurakal, J., Huerta-Lavorie, R., Nguyen, A.I., Tilley, T.D., Borovik, A.S. Description: Artificial Met...

OCA — Wed, 27 Sep 2017 16:49:03 GMT

New page: '''Unreleased structure''' The entry 6auo is ON HOLD Authors: Olshansky, L., Vallapurakal, J., Huerta-Lavorie, R., Nguyen, A.I., Tilley, T.D., Borovik, A.S. Description: Artificial Met...

New page

'''Unreleased structure'''

The entry 6auo is ON HOLD

Authors: Olshansky, L., Vallapurakal, J., Huerta-Lavorie, R., Nguyen, A.I., Tilley, T.D., Borovik, A.S.

Description: Artificial Metalloproteins Containing a Co4O4 Active Site -2xm-S112F
[[Category: Unreleased Structures]]
[[Category: Borovik, A.S]]
[[Category: Vallapurakal, J]]
[[Category: Tilley, T.D]]
[[Category: Nguyen, A.I]]
[[Category: Huerta-Lavorie, R]]
[[Category: Olshansky, L]]