6ava - Revision history

OCA at 14:26, 4 October 2023

OCA — Wed, 04 Oct 2023 14:26:11 GMT

←Older revision		Revision as of 14:26, 4 October 2023
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	<StructureSection load='6ava' size='340' side='right'caption='[[6ava]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='6ava' size='340' side='right'caption='[[6ava]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ava]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Buthus_eupeus Buthus~~ eupeus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AVA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6AVA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ava]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesobuthus_eupeus Mesobuthus eupeus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AVA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AVA FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[6atl\|6atl]]~~, [[~~6atm~~\|~~6atm]], [[6atn\|6atn]], [[6ats\|6ats]], [[6atu\|6atu]], [[6atw\|6atw]], [[6aty\|6aty]], [[6au7\|6au7]], [[6aup\|6aup]], [[6av8\|6av8~~]]</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6ava FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ava OCA], [~~http~~://pdbe.org/6ava PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6ava RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6ava PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6ava ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ava FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ava OCA], [https://pdbe.org/6ava PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ava RCSB], [https://www.ebi.ac.uk/pdbsum/6ava PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ava ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CTXI1_MESEU CTXI1_MESEU]] Toxin with unknown function in healthy organisms. On glioma cells, interacts with chloride channels (probably ClC-3/CLCN3) and MMP2 at the surface of glioma cells. This complex is then internalized via caveolae, thus inhibiting the chloride channels necessary for cell shrinkage and tumor propagation (By similarity).	+	[https://www.uniprot.org/uniprot/CTXI1_MESEU CTXI1_MESEU] Toxin with unknown function in healthy organisms. On glioma cells, interacts with chloride channels (probably ClC-3/CLCN3) and MMP2 at the surface of glioma cells. This complex is then internalized via caveolae, thus inhibiting the chloride channels necessary for cell shrinkage and tumor propagation (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buthus eupeus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Gewe, M M~~]]	+	[[Category: Mesobuthus eupeus]]
-	[[Category: ~~Rupert, P~~]]	+	[[Category: Gewe MM]]
-	[[Category: ~~Strong, R K~~]]	+	[[Category: Rupert P]]
-	[[Category: ~~Cystine knot]]~~	+	[[Category: Strong RK]]
-	~~[[Category: Knottin]]~~	+
-	~~[[Category: Toxin~~]]	+

OCA at 21:32, 28 October 2020

OCA — Wed, 28 Oct 2020 21:32:37 GMT

←Older revision		Revision as of 21:32, 28 October 2020
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	==Exploring Cystine Dense Peptide Space to Open a Unique Molecular Toolbox==		==Exploring Cystine Dense Peptide Space to Open a Unique Molecular Toolbox==
-	<StructureSection load='6ava' size='340' side='right' caption='[[6ava]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='6ava' size='340' side='right'caption='[[6ava]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ava]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buthus_eupeus Buthus eupeus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AVA OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6AVA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ava]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buthus_eupeus Buthus eupeus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AVA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6AVA FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6atl\|6atl]], [[6atm\|6atm]], [[6atn\|6atn]], [[6ats\|6ats]], [[6atu\|6atu]], [[6atw\|6atw]], [[6aty\|6aty]], [[6au7\|6au7]], [[6aup\|6aup]], [[6av8\|6av8]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6atl\|6atl]], [[6atm\|6atm]], [[6atn\|6atn]], [[6ats\|6ats]], [[6atu\|6atu]], [[6atw\|6atw]], [[6aty\|6aty]], [[6au7\|6au7]], [[6aup\|6aup]], [[6av8\|6av8]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6ava FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ava OCA], [http://pdbe.org/6ava PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ava RCSB], [http://www.ebi.ac.uk/pdbsum/6ava PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ava ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6ava FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ava OCA], [http://pdbe.org/6ava PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ava RCSB], [http://www.ebi.ac.uk/pdbsum/6ava PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ava ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</StructureSection>		</StructureSection>
	[[Category: Buthus eupeus]]		[[Category: Buthus eupeus]]
		+	[[Category: Large Structures]]
	[[Category: Gewe, M M]]		[[Category: Gewe, M M]]
	[[Category: Rupert, P]]		[[Category: Rupert, P]]

OCA at 07:00, 14 March 2018

OCA — Wed, 14 Mar 2018 07:00:38 GMT

←Older revision		Revision as of 07:00, 14 March 2018
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	<StructureSection load='6ava' size='340' side='right' caption='[[6ava]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='6ava' size='340' side='right' caption='[[6ava]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ava]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AVA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AVA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ava]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buthus_eupeus Buthus eupeus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AVA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AVA FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6atl\|6atl]], [[6atm\|6atm]], [[6atn\|6atn]], [[6ats\|6ats]], [[6atu\|6atu]], [[6atw\|6atw]], [[6aty\|6aty]], [[6au7\|6au7]], [[6aup\|6aup]], [[6av8\|6av8]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6atl\|6atl]], [[6atm\|6atm]], [[6atn\|6atn]], [[6ats\|6ats]], [[6atu\|6atu]], [[6atw\|6atw]], [[6aty\|6aty]], [[6au7\|6au7]], [[6aup\|6aup]], [[6av8\|6av8]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ava FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ava OCA], [http://pdbe.org/6ava PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ava RCSB], [http://www.ebi.ac.uk/pdbsum/6ava PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ava ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ava FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ava OCA], [http://pdbe.org/6ava PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ava RCSB], [http://www.ebi.ac.uk/pdbsum/6ava PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ava ProSAT]</span></td></tr>
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	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/CTXI1_MESEU CTXI1_MESEU]] Toxin with unknown function in healthy organisms. On glioma cells, interacts with chloride channels (probably ClC-3/CLCN3) and MMP2 at the surface of glioma cells. This complex is then internalized via caveolae, thus inhibiting the chloride channels necessary for cell shrinkage and tumor propagation (By similarity).		[[http://www.uniprot.org/uniprot/CTXI1_MESEU CTXI1_MESEU]] Toxin with unknown function in healthy organisms. On glioma cells, interacts with chloride channels (probably ClC-3/CLCN3) and MMP2 at the surface of glioma cells. This complex is then internalized via caveolae, thus inhibiting the chloride channels necessary for cell shrinkage and tumor propagation (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Peptides folded through interwoven disulfides display extreme biochemical properties and unique medicinal potential. However, their exploitation has been hampered by the limited amounts isolatable from natural sources and the expense of chemical synthesis. We developed reliable biological methods for high-throughput expression, screening and large-scale production of these peptides: 46 were successfully produced in multimilligram quantities, and >600 more were deemed expressible through stringent screening criteria. Many showed extreme resistance to temperature, proteolysis and/or reduction, and all displayed inhibitory activity against at least 1 of 20 ion channels tested, thus confirming their biological functionality. Crystal structures of 12 confirmed proper cystine topology and the utility of crystallography to study these molecules but also highlighted the need for rational classification. Previous categorization attempts have focused on limited subsets featuring distinct motifs. Here we present a global definition, classification and analysis of >700 structures of cystine-dense peptides, providing a unifying framework for these molecules.
		+
		+	Screening, large-scale production and structure-based classification of cystine-dense peptides.,Correnti CE, Gewe MM, Mehlin C, Bandaranayake AD, Johnsen WA, Rupert PB, Brusniak MY, Clarke M, Burke SE, De Van Der Schueren W, Pilat K, Turnbaugh SM, May D, Watson A, Chan MK, Bahl CD, Olson JM, Strong RK Nat Struct Mol Biol. 2018 Mar;25(3):270-278. doi: 10.1038/s41594-018-0033-9. Epub, 2018 Feb 26. PMID:29483648<ref>PMID:29483648</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6ava" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Buthus eupeus]]
	[[Category: Gewe, M M]]		[[Category: Gewe, M M]]
	[[Category: Rupert, P]]		[[Category: Rupert, P]]

OCA at 06:30, 28 February 2018

OCA — Wed, 28 Feb 2018 06:30:12 GMT

←Older revision		Revision as of 06:30, 28 February 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6ava is ~~ON HOLD until Paper Publication~~	+	==Exploring Cystine Dense Peptide Space to Open a Unique Molecular Toolbox==
-		+	<StructureSection load='6ava' size='340' side='right' caption='[[6ava]], [[Resolution\|resolution]] 2.20Å' scene=''>
-	~~Authors~~: ~~Gewe~~, M.M., ~~Rupert~~, P., ~~Strong~~, R.K.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6ava]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AVA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AVA FirstGlance]. <br>
-	~~Description: Exploring Cystine Dense Peptide Space to Open a Unique Molecular Toolbox~~	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6atl\|6atl]], [[6atm\|6atm]], [[6atn\|6atn]], [[6ats\|6ats]], [[6atu\|6atu]], [[6atw\|6atw]], [[6aty\|6aty]], [[6au7\|6au7]], [[6aup\|6aup]], [[6av8\|6av8]]</td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ava FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ava OCA], [http://pdbe.org/6ava PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ava RCSB], [http://www.ebi.ac.uk/pdbsum/6ava PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ava ProSAT]</span></td></tr>
-	[[Category: Gewe, M.M]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CTXI1_MESEU CTXI1_MESEU]] Toxin with unknown function in healthy organisms. On glioma cells, interacts with chloride channels (probably ClC-3/CLCN3) and MMP2 at the surface of glioma cells. This complex is then internalized via caveolae, thus inhibiting the chloride channels necessary for cell shrinkage and tumor propagation (By similarity).
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Gewe, M M]]
	[[Category: Rupert, P]]		[[Category: Rupert, P]]
-	[[Category: Strong, R.K]]	+	[[Category: Strong, R K]]
		+	[[Category: Cystine knot]]
		+	[[Category: Knottin]]
		+	[[Category: Toxin]]

OCA at 05:38, 17 January 2018

OCA — Wed, 17 Jan 2018 05:38:44 GMT

←Older revision		Revision as of 05:38, 17 January 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6ava is ON HOLD	+	The entry 6ava is ON HOLD until Paper Publication

	Authors: Gewe, M.M., Rupert, P., Strong, R.K.		Authors: Gewe, M.M., Rupert, P., Strong, R.K.
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	Description: Exploring Cystine Dense Peptide Space to Open a Unique Molecular Toolbox		Description: Exploring Cystine Dense Peptide Space to Open a Unique Molecular Toolbox
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Strong, R.K]]
	[[Category: Gewe, M.M]]		[[Category: Gewe, M.M]]
	[[Category: Rupert, P]]		[[Category: Rupert, P]]
		+	[[Category: Strong, R.K]]

OCA: Protected "6ava" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2017 16:49:59 GMT

Protected "6ava" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:49, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 6ava is ON HOLD Authors: Gewe, M.M., Rupert, P., Strong, R.K. Description: Exploring Cystine Dense Peptide Space to Open a Unique Molecular Toolbox...

OCA — Wed, 27 Sep 2017 16:49:58 GMT

New page: '''Unreleased structure''' The entry 6ava is ON HOLD Authors: Gewe, M.M., Rupert, P., Strong, R.K. Description: Exploring Cystine Dense Peptide Space to Open a Unique Molecular Toolbox...

New page

'''Unreleased structure'''

The entry 6ava is ON HOLD

Authors: Gewe, M.M., Rupert, P., Strong, R.K.

Description: Exploring Cystine Dense Peptide Space to Open a Unique Molecular Toolbox
[[Category: Unreleased Structures]]
[[Category: Strong, R.K]]
[[Category: Gewe, M.M]]
[[Category: Rupert, P]]