6ay9 - Revision history

OCA at 14:28, 4 October 2023

OCA — Wed, 04 Oct 2023 14:28:32 GMT

←Older revision		Revision as of 14:28, 4 October 2023
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	<StructureSection load='6ay9' size='340' side='right'caption='[[6ay9]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='6ay9' size='340' side='right'caption='[[6ay9]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ay9]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~9hiv1 9hiv1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AY9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6AY9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ay9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AY9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AY9 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=CL:CHLORIDE+ION'>CL</scene~~>, ~~<scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[4xfx\|4xfx]]~~<~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">gag ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ay9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ay9 OCA], [https://pdbe.org/6ay9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ay9 RCSB], [https://www.ebi.ac.uk/pdbsum/6ay9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ay9 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6ay9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ay9 OCA], [~~http~~://pdbe.org/6ay9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6ay9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6ay9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6ay9 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~CPSF6_HUMAN CPSF6_HUMAN~~]~~] Component~~ of the ~~cleavage factor Im~~ complex (~~CFIm~~) ~~that~~ plays a ~~key~~ role in ~~pre-mRNA 3'-processing. Involved in association~~ with ~~NUDT21~~/~~CPSF5 in pre-MRNA 3'-end poly~~(A) ~~site cleavage and poly(A) addition~~. CPSF6 binds to cleavage and polyadenylation RNA substrates and promotes RNA looping.<ref>PMID:9659921</ref> <ref>PMID:8626397</ref> <ref>PMID:14690600</ref> <ref>PMID:20695905</ref> <ref>PMID:21295486</ref>	+	[https://www.uniprot.org/uniprot/GAG_HV1N5 GAG_HV1N5] Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex. Implicated in the release from host cell mediated by Vpu. Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex. Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers. p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1 (By similarity).
-	== ~~References~~ ==	+
-	~~<references/>~~	+	==See Also==
		+	*[[Gag polyprotein 3D structures\|Gag polyprotein 3D structures]]
		+	*[[Virus coat proteins 3D structures\|Virus coat proteins 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Human immunodeficiency virus 1]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gres~~, A T~~]]	+	[[Category: Gres AT]]
-	[[Category: Kirby~~, K A~~]]	+	[[Category: Kirby KA]]
-	[[Category: Sarafianos~~, S G]]~~	+	[[Category: Sarafianos SG]]
-	~~[[Category: Cpsf6 complex]]~~	+
-	~~[[Category: Hexamer]]~~	+
-	~~[[Category: Hiv-1 capsid protein]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 17:41, 11 December 2019

OCA — Wed, 11 Dec 2019 17:41:30 GMT

←Older revision		Revision as of 17:41, 11 December 2019
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	==Structure of the native full-length HIV-1 capsid protein in complex with CPSF6 peptide==		==Structure of the native full-length HIV-1 capsid protein in complex with CPSF6 peptide==
-	<StructureSection load='6ay9' size='340' side='right' caption='[[6ay9]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='6ay9' size='340' side='right'caption='[[6ay9]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6ay9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AY9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AY9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[6ay9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AY9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AY9 FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Gres, A T]]		[[Category: Gres, A T]]
	[[Category: Kirby, K A]]		[[Category: Kirby, K A]]

OCA at 07:45, 21 February 2019

OCA — Thu, 21 Feb 2019 07:45:34 GMT

←Older revision		Revision as of 07:45, 21 February 2019
Line 3:		Line 3:
	<StructureSection load='6ay9' size='340' side='right' caption='[[6ay9]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='6ay9' size='340' side='right' caption='[[6ay9]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ay9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AY9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AY9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ay9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AY9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AY9 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xfx\|4xfx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xfx\|4xfx]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">gag ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ay9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ay9 OCA], [http://pdbe.org/6ay9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ay9 RCSB], [http://www.ebi.ac.uk/pdbsum/6ay9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ay9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ay9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ay9 OCA], [http://pdbe.org/6ay9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ay9 RCSB], [http://www.ebi.ac.uk/pdbsum/6ay9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ay9 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:33, 12 September 2018

OCA — Wed, 12 Sep 2018 07:33:19 GMT

←Older revision		Revision as of 07:33, 12 September 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6ay9 is ~~ON HOLD~~ ~~until Sep 07 2019~~	+	==Structure of the native full-length HIV-1 capsid protein in complex with CPSF6 peptide==
-		+	<StructureSection load='6ay9' size='340' side='right' caption='[[6ay9]], [[Resolution\|resolution]] 2.50Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6ay9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AY9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AY9 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4xfx\|4xfx]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ay9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ay9 OCA], [http://pdbe.org/6ay9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ay9 RCSB], [http://www.ebi.ac.uk/pdbsum/6ay9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ay9 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CPSF6_HUMAN CPSF6_HUMAN]] Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3'-processing. Involved in association with NUDT21/CPSF5 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. CPSF6 binds to cleavage and polyadenylation RNA substrates and promotes RNA looping.<ref>PMID:9659921</ref> <ref>PMID:8626397</ref> <ref>PMID:14690600</ref> <ref>PMID:20695905</ref> <ref>PMID:21295486</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Gres, A T]]
		+	[[Category: Kirby, K A]]
		+	[[Category: Sarafianos, S G]]
		+	[[Category: Cpsf6 complex]]
		+	[[Category: Hexamer]]
		+	[[Category: Hiv-1 capsid protein]]
		+	[[Category: Viral protein]]

OCA: Protected "6ay9" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2017 16:57:08 GMT

Protected "6ay9" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:57, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 6ay9 is ON HOLD until Sep 07 2019 Authors: Description: Category: Unreleased Structures

OCA — Wed, 27 Sep 2017 16:57:07 GMT

New page: '''Unreleased structure''' The entry 6ay9 is ON HOLD until Sep 07 2019 Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6ay9 is ON HOLD until Sep 07 2019

Authors:

Description:
[[Category: Unreleased Structures]]