6b20 - Revision history

OCA at 14:30, 4 October 2023

OCA — Wed, 04 Oct 2023 14:30:44 GMT

←Older revision		Revision as of 14:30, 4 October 2023
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	<StructureSection load='6b20' size='340' side='right'caption='[[6b20]], [[Resolution\|resolution]] 2.34Å' scene=''>		<StructureSection load='6b20' size='340' side='right'caption='[[6b20]], [[Resolution\|resolution]] 2.34Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6b20]] is a 6 chain structure with sequence from [~~http://en.wikipedia.org/wiki/Bovin Bovin], [http~~://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [~~http~~://en.wikipedia.org/wiki/~~Camelus_glama Camelus~~ glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B20 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6B20 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6b20]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B20 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6B20 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.34Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6b20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b20 OCA], [~~http~~://pdbe.org/6b20 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6b20 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6b20 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6b20 ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6b20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b20 OCA], [https://pdbe.org/6b20 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6b20 RCSB], [https://www.ebi.ac.uk/pdbsum/6b20 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6b20 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/GBB1_BOVIN GBB1_BOVIN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. [[http://www.uniprot.org/uniprot/GBG1_BOVIN GBG1_BOVIN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	+	[https://www.uniprot.org/uniprot/GBB1_BOVIN GBB1_BOVIN] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 21:

	==See Also==		==See Also==
		+	*[[GTP-binding protein 3D structures\|GTP-binding protein 3D structures]]
	*[[Transducin 3D structures\|Transducin 3D structures]]		*[[Transducin 3D structures\|Transducin 3D structures]]
	== References ==		== References ==
Line 26:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
-	[[Category: ~~Bovin]]~~	+	[[Category: Lama glama]]
-	~~[[Category: Camelus~~ glama]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gulati, S]]	+	[[Category: Gulati S]]
-	[[Category: Kiser~~, P D~~]]	+	[[Category: Kiser PD]]
-	[[Category: Palczewski, K]]	+	[[Category: Palczewski K]]
-	~~[[Category: Beta propeller]]~~	+
-	~~[[Category: G protein]]~~	+
-	~~[[Category: G protein coupled receptor-signaling]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 21:35, 28 October 2020

OCA — Wed, 28 Oct 2020 21:35:39 GMT

←Older revision		Revision as of 21:35, 28 October 2020
Line 1:		Line 1:

	==Crystal structure of a complex between G protein beta gamma dimer and an inhibitory Nanobody regulator==		==Crystal structure of a complex between G protein beta gamma dimer and an inhibitory Nanobody regulator==
-	<StructureSection load='6b20' size='340' side='right' caption='[[6b20]], [[Resolution\|resolution]] 2.34Å' scene=''>	+	<StructureSection load='6b20' size='340' side='right'caption='[[6b20]], [[Resolution\|resolution]] 2.34Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6b20]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin], [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Camelus_glama Camelus glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B20 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6B20 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6b20]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin], [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Camelus_glama Camelus glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B20 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6B20 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6b20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b20 OCA], [http://pdbe.org/6b20 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b20 RCSB], [http://www.ebi.ac.uk/pdbsum/6b20 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b20 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6b20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b20 OCA], [http://pdbe.org/6b20 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b20 RCSB], [http://www.ebi.ac.uk/pdbsum/6b20 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b20 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 6b20" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6b20" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Transducin 3D structures\|Transducin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 25:		Line 28:
	[[Category: Bovin]]		[[Category: Bovin]]
	[[Category: Camelus glama]]		[[Category: Camelus glama]]
		+	[[Category: Large Structures]]
	[[Category: Gulati, S]]		[[Category: Gulati, S]]
	[[Category: Kiser, P D]]		[[Category: Kiser, P D]]

OCA at 16:36, 15 August 2018

OCA — Wed, 15 Aug 2018 16:36:00 GMT

←Older revision		Revision as of 16:36, 15 August 2018
Line 3:		Line 3:
	<StructureSection load='6b20' size='340' side='right' caption='[[6b20]], [[Resolution\|resolution]] 2.34Å' scene=''>		<StructureSection load='6b20' size='340' side='right' caption='[[6b20]], [[Resolution\|resolution]] 2.34Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6b20]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] ~~and~~ [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B20 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B20 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6b20]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin], [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Camelus_glama Camelus glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B20 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B20 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b20 OCA], [http://pdbe.org/6b20 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b20 RCSB], [http://www.ebi.ac.uk/pdbsum/6b20 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b20 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b20 OCA], [http://pdbe.org/6b20 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b20 RCSB], [http://www.ebi.ac.uk/pdbsum/6b20 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b20 ProSAT]</span></td></tr>
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
		+	[[Category: Bovin]]
		+	[[Category: Camelus glama]]
	[[Category: Gulati, S]]		[[Category: Gulati, S]]
	[[Category: Kiser, P D]]		[[Category: Kiser, P D]]

OCA at 05:31, 30 May 2018

OCA — Wed, 30 May 2018 05:31:49 GMT

←Older revision		Revision as of 05:31, 30 May 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6b20 is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of a complex between G protein beta gamma dimer and an inhibitory Nanobody regulator==
		+	<StructureSection load='6b20' size='340' side='right' caption='[[6b20]], [[Resolution\|resolution]] 2.34Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6b20]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B20 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B20 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b20 OCA], [http://pdbe.org/6b20 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b20 RCSB], [http://www.ebi.ac.uk/pdbsum/6b20 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b20 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GBB1_BOVIN GBB1_BOVIN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. [[http://www.uniprot.org/uniprot/GBG1_BOVIN GBG1_BOVIN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	G protein-coupled receptors (GPCRs) activate heterotrimeric G proteins by mediating a GDP to GTP exchange in the Galpha subunit. This leads to dissociation of the heterotrimer into Galpha-GTP and Gbetagamma dimer. The Galpha-GTP and Gbetagamma dimer each regulate a variety of downstream pathways to control various aspects of human physiology. Dysregulated Gbetagamma-signaling is a central element of various neurological and cancer-related anomalies. However, Gbetagamma also serves as a negative regulator of Galpha that is essential for G protein inactivation, and thus has the potential for numerous side effects when targeted therapeutically. Here we report a llama-derived nanobody (Nb5) that binds tightly to the Gbetagamma dimer. Nb5 responds to all combinations of beta-subtypes and gamma-subtypes and competes with other Gbetagamma-regulatory proteins for a common binding site on the Gbetagamma dimer. Despite its inhibitory effect on Gbetagamma-mediated signaling, Nb5 has no effect on Galphaq-mediated and Galphas-mediated signaling events in living cells.

-	~~Authors: Gulati~~, S., Kiser, ~~P.D.~~, ~~Palczewski~~, K.	+	Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor.,Gulati S, Jin H, Masuho I, Orban T, Cai Y, Pardon E, Martemyanov KA, Kiser PD, Stewart PL, Ford CP, Steyaert J, Palczewski K Nat Commun. 2018 May 18;9(1):1996. doi: 10.1038/s41467-018-04432-0. PMID:29777099<ref>PMID:29777099</ref>

-	~~Description: Crystal structure of~~ a ~~complex between G protein beta gamma dimer and an inhibitory Nanobody regulator~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 6b20" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Bos taurus]]
	[[Category: Gulati, S]]		[[Category: Gulati, S]]
-	[[Category: Kiser, P.D]]	+	[[Category: Kiser, P D]]
	[[Category: Palczewski, K]]		[[Category: Palczewski, K]]
		+	[[Category: Beta propeller]]
		+	[[Category: G protein]]
		+	[[Category: G protein coupled receptor-signaling]]
		+	[[Category: Signaling protein]]

OCA: Protected "6b20" [edit=sysop:move=sysop]

OCA — Wed, 27 Sep 2017 17:04:42 GMT

Protected "6b20" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:04, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 6b20 is ON HOLD until Paper Publication Authors: Gulati, S., Kiser, P.D., Palczewski, K. Description: Crystal structure of a complex between G prot...

OCA — Wed, 27 Sep 2017 17:04:41 GMT

New page: '''Unreleased structure''' The entry 6b20 is ON HOLD until Paper Publication Authors: Gulati, S., Kiser, P.D., Palczewski, K. Description: Crystal structure of a complex between G prot...

New page

'''Unreleased structure'''

The entry 6b20 is ON HOLD until Paper Publication

Authors: Gulati, S., Kiser, P.D., Palczewski, K.

Description: Crystal structure of a complex between G protein beta gamma dimer and an inhibitory Nanobody regulator
[[Category: Unreleased Structures]]
[[Category: Gulati, S]]
[[Category: Kiser, P.D]]
[[Category: Palczewski, K]]