6b3w - Revision history

OCA at 14:32, 4 October 2023

OCA — Wed, 04 Oct 2023 14:32:23 GMT

←Older revision		Revision as of 14:32, 4 October 2023
Line 1:		Line 1:

	==Structure of Hs/AcPRC2 in complex with 5,8-dichloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one==		==Structure of Hs/AcPRC2 in complex with 5,8-dichloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one==
-	<StructureSection load='6b3w' size='340' side='right' caption='[[6b3w]], [[Resolution\|resolution]] 3.05Å' scene=''>	+	<StructureSection load='6b3w' size='340' side='right'caption='[[6b3w]], [[Resolution\|resolution]] 3.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6b3w]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Anoca Anoca~~] and [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B3W OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6B3W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6b3w]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Anolis_carolinensis Anolis carolinensis] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B3W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6B3W FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CJG:5,8-dichloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one'>CJG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.05Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EZH2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28377 ANOCA]), EED ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), SUZ12, CHET9, JJAZ1, KIAA0160 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CJG:5,8-dichloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one'>CJG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6b3w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b3w OCA], [~~http~~://pdbe.org/6b3w PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6b3w RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6b3w PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6b3w ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6b3w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b3w OCA], [https://pdbe.org/6b3w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6b3w RCSB], [https://www.ebi.ac.uk/pdbsum/6b3w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6b3w ProSAT]</span></td></tr>
	</table>		</table>
-	== Disease ==
-	[[http://www.uniprot.org/uniprot/SUZ12_HUMAN SUZ12_HUMAN]] A chromosomal aberration involving SUZ12 may be a cause of endometrial stromal tumors. Translocation t(7;17)(p15;q21) with JAZF1. The translocation generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part of JAZF1 and the C-terminus part of SUZ12. It is frequently found in all cases of endometrial stromal tumors, except in endometrial stromal sarcomas, where it is rarer.<ref>PMID:11371647</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~SUZ12_HUMAN SUZ12_HUMAN~~]] Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.<ref>PMID:15225548</ref> <ref>PMID:15231737</ref> <ref>PMID:15385962</ref> <ref>PMID:16618801</ref> <ref>PMID:17344414</ref> <ref>PMID:18285464</ref> [[http://www.uniprot.org/uniprot/EED_HUMAN EED_HUMAN]] Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.<ref>PMID:9584199</ref> <ref>PMID:10581039</ref> <ref>PMID:14532106</ref> <ref>PMID:15385962</ref> <ref>PMID:15231737</ref> <ref>PMID:15225548</ref> <ref>PMID:16357870</ref> <ref>PMID:18285464</ref> <ref>PMID:20974918</ref>	+	[https://www.uniprot.org/uniprot/G1KPH4_ANOCA G1KPH4_ANOCA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 6b3w" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6b3w" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Polycomb complex proteins 3D structures\|Polycomb complex proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Anoca~~]]	+	[[Category: Anolis carolinensis]]
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: Brooun, A]]	+	[[Category: Large Structures]]
-	[[Category: Deng, Y]]	+	[[Category: Brooun A]]
-	[[Category: Gajiwala~~, K S~~]]	+	[[Category: Deng Y]]
-	[[Category: Liu, W]]	+	[[Category: Gajiwala KS]]
-	[[Category: Stewart~~, A E]]~~	+	[[Category: Liu W]]
-	~~[[Category: Lysine methyltransferase]]~~	+	[[Category: Stewart AE]]
-	~~[[Category: Metal binding protein~~]]	+

OCA at 08:26, 22 February 2018

OCA — Thu, 22 Feb 2018 08:26:32 GMT

←Older revision		Revision as of 08:26, 22 February 2018
Line 3:		Line 3:
	<StructureSection load='6b3w' size='340' side='right' caption='[[6b3w]], [[Resolution\|resolution]] 3.05Å' scene=''>		<StructureSection load='6b3w' size='340' side='right' caption='[[6b3w]], [[Resolution\|resolution]] 3.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6b3w]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B3W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B3W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6b3w]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Anoca Anoca] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B3W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B3W FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CJG:5,8-dichloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one'>CJG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CJG:5,8-dichloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one'>CJG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EZH2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28377 ANOCA]), EED ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), SUZ12, CHET9, JJAZ1, KIAA0160 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b3w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b3w OCA], [http://pdbe.org/6b3w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b3w RCSB], [http://www.ebi.ac.uk/pdbsum/6b3w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b3w ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b3w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b3w OCA], [http://pdbe.org/6b3w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b3w RCSB], [http://www.ebi.ac.uk/pdbsum/6b3w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b3w ProSAT]</span></td></tr>
	</table>		</table>
Line 24:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Anoca]]
		+	[[Category: Human]]
	[[Category: Brooun, A]]		[[Category: Brooun, A]]
	[[Category: Deng, Y]]		[[Category: Deng, Y]]

OCA at 08:37, 27 December 2017

OCA — Wed, 27 Dec 2017 08:37:06 GMT

←Older revision		Revision as of 08:37, 27 December 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6b3w is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Structure of Hs/AcPRC2 in complex with 5,8-dichloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one==
		+	<StructureSection load='6b3w' size='340' side='right' caption='[[6b3w]], [[Resolution\|resolution]] 3.05Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6b3w]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B3W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B3W FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CJG:5,8-dichloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one'>CJG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b3w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b3w OCA], [http://pdbe.org/6b3w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b3w RCSB], [http://www.ebi.ac.uk/pdbsum/6b3w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b3w ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/SUZ12_HUMAN SUZ12_HUMAN]] A chromosomal aberration involving SUZ12 may be a cause of endometrial stromal tumors. Translocation t(7;17)(p15;q21) with JAZF1. The translocation generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part of JAZF1 and the C-terminus part of SUZ12. It is frequently found in all cases of endometrial stromal tumors, except in endometrial stromal sarcomas, where it is rarer.<ref>PMID:11371647</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SUZ12_HUMAN SUZ12_HUMAN]] Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.<ref>PMID:15225548</ref> <ref>PMID:15231737</ref> <ref>PMID:15385962</ref> <ref>PMID:16618801</ref> <ref>PMID:17344414</ref> <ref>PMID:18285464</ref> [[http://www.uniprot.org/uniprot/EED_HUMAN EED_HUMAN]] Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.<ref>PMID:9584199</ref> <ref>PMID:10581039</ref> <ref>PMID:14532106</ref> <ref>PMID:15385962</ref> <ref>PMID:15231737</ref> <ref>PMID:15225548</ref> <ref>PMID:16357870</ref> <ref>PMID:18285464</ref> <ref>PMID:20974918</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A new series of lactam-derived EZH2 inhibitors was designed via a ligand- and physicochemical property-based strategy to address metabolic stability and thermodynamic solubility issues associated with previous lead compound 1. The new inhibitors incorporated an sp3 hybridized carbon atom at the 7-position of the lactam moiety present in lead compound 1 as a replacement for a dimethylisoxazole group. This transformation enabled optimization of the physicochemical properties and potency compared to compound 1. Analysis of relationships between calculated logD (cLogD) values and in vitro metabolic stability and permeability parameters identified a clogD range that afforded an increased probability of achieving favorable ADME data in a single molecule. Compound 23a exhibited the best overlap of potency and pharmaceutical properties as well as robust tumor growth inhibition in vivo and was therefore advanced as a development candidate (PF-06821497). A crystal structure of 23a in complex with the three-protein PRC2 complex enabled understanding of the key structural features required for optimal binding.

-	~~Authors~~: ~~Gajiwala~~, ~~K.S~~., ~~Brooun~~, A., ~~Liu~~, W., ~~Deng~~, Y., Stewart, A.E.	+	Optimization of orally bioavailable enhancer of zeste homolog 2 (EZH2) inhibitors using ligand and property-based design strategies: Identification of development candidate (R)-5,8-dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2- dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497).,Kung PP, Bingham P, Brooun A, Collins MR, Deng YL, Dinh DM, Fan C, Gajiwala KS, Grantner R, Gukasyan HJ, Hu W, Huang B, Kania RS, Kephart SE, Krivacic CT, Kumpf RA, Khamphavong P, Kraus M, Liu W, Maegley KA, Nguyen L, Ren S, Richter DT, Rollins RA, Sach NW, Sharma S, Sherrill J, Spangler JE, Stewart AE, Sutton SC, Uryu S, Verhelle D, Wang H, Wang S, Wythes M, Xin S, Yamazaki S, Zhu H, Zhu J, Zehnder L, Edwards MP J Med Chem. 2017 Dec 6. doi: 10.1021/acs.jmedchem.7b01375. PMID:29211475<ref>PMID:29211475</ref>

-	~~Description: Structure~~ of Hs/~~AcPRC2 in complex with 5,8~~-~~dichloro~~-~~7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	~~[[Category: Stewart, A.E]]~~	+	<div class="pdbe-citations 6b3w" style="background-color:#fffaf0;"></div>
-	~~[[Category: Liu, W]]~~	+	== References ==
-	~~[[Category: Gajiwala, K.S]]~~	+	<references/>
-	~~[[Category: Deng, Y]]~~	+	__TOC__
		+	</StructureSection>
	[[Category: Brooun, A]]		[[Category: Brooun, A]]
		+	[[Category: Deng, Y]]
		+	[[Category: Gajiwala, K S]]
		+	[[Category: Liu, W]]
		+	[[Category: Stewart, A E]]
		+	[[Category: Lysine methyltransferase]]
		+	[[Category: Metal binding protein]]

OCA at 05:02, 29 November 2017

OCA — Wed, 29 Nov 2017 05:02:22 GMT

←Older revision		Revision as of 05:02, 29 November 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6b3w is ON HOLD	+	The entry 6b3w is ON HOLD until Paper Publication

	Authors: Gajiwala, K.S., Brooun, A., Liu, W., Deng, Y., Stewart, A.E.		Authors: Gajiwala, K.S., Brooun, A., Liu, W., Deng, Y., Stewart, A.E.
Line 9:		Line 9:
	[[Category: Stewart, A.E]]		[[Category: Stewart, A.E]]
	[[Category: Liu, W]]		[[Category: Liu, W]]
-	[[Category: Deng, Y]]
	[[Category: Gajiwala, K.S]]		[[Category: Gajiwala, K.S]]
		+	[[Category: Deng, Y]]
	[[Category: Brooun, A]]		[[Category: Brooun, A]]

OCA: Protected "6b3w" [edit=sysop:move=sysop]

OCA — Wed, 04 Oct 2017 08:12:11 GMT

Protected "6b3w" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:12, 4 October 2017

OCA: New page: '''Unreleased structure''' The entry 6b3w is ON HOLD Authors: Gajiwala, K.S., Brooun, A., Liu, W., Deng, Y., Stewart, A.E. Description: Structure of Hs/AcPRC2 in complex with 5,8-dichl...

OCA — Wed, 04 Oct 2017 08:12:09 GMT

New page: '''Unreleased structure''' The entry 6b3w is ON HOLD Authors: Gajiwala, K.S., Brooun, A., Liu, W., Deng, Y., Stewart, A.E. Description: Structure of Hs/AcPRC2 in complex with 5,8-dichl...

New page

'''Unreleased structure'''

The entry 6b3w is ON HOLD

Authors: Gajiwala, K.S., Brooun, A., Liu, W., Deng, Y., Stewart, A.E.

Description: Structure of Hs/AcPRC2 in complex with 5,8-dichloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one
[[Category: Unreleased Structures]]
[[Category: Stewart, A.E]]
[[Category: Liu, W]]
[[Category: Deng, Y]]
[[Category: Gajiwala, K.S]]
[[Category: Brooun, A]]