6b77 - Revision history

OCA at 14:34, 4 October 2023

OCA — Wed, 04 Oct 2023 14:34:18 GMT

←Older revision		Revision as of 14:34, 4 October 2023
Line 3:		Line 3:
	<StructureSection load='6b77' size='340' side='right'caption='[[6b77]], [[Resolution\|resolution]] 2.37Å' scene=''>		<StructureSection load='6b77' size='340' side='right'caption='[[6b77]], [[Resolution\|resolution]] 2.37Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6b77]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B77 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6B77 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6b77]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B77 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6B77 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CWV:[3-(1-aminoisoquinolin-6-yl)phenyl]boronic+acid'>CWV</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD~~</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4~~</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><~~/td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.37Å</td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat">[[6b74\|6b74]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CWV:[3-(1-aminoisoquinolin-6-yl)phenyl]boronic+acid'>CWV</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='activity~~'>~~<td class="sblockLbl"><b>Activity:~~</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_XIIa Coagulation factor XIIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.38 3.4.21.38] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6b77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b77 OCA], [https://pdbe.org/6b77 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6b77 RCSB], [https://www.ebi.ac.uk/pdbsum/6b77 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6b77 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6b77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b77 OCA], [~~http~~://pdbe.org/6b77 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6b77 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6b77 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6b77 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/FA12_HUMAN FA12_HUMAN]] Congenital factor XII deficiency;Hereditary angioedema type 3. Defects in F12 are the cause of factor XII deficiency (FA12D) [MIM:[~~http~~://omim.org/entry/234000 234000]]; also known as Hageman factor deficiency. This trait is an asymptomatic anomaly of in vitro blood coagulation. Its diagnosis is based on finding a low plasma activity of the factor in coagulating assays. It is usually only accidentally discovered through pre-operative blood tests. F12 deficiency is divided into two categories, a cross-reacting material (CRM)-negative group (negative F12 antigen detection) and a CRM-positive group (positive F12 antigen detection).<ref>PMID:8528215</ref> <ref>PMID:2882793</ref> <ref>PMID:2510163</ref> <ref>PMID:8049433</ref> <ref>PMID:9354665</ref> <ref>PMID:10361128</ref> <ref>PMID:11776307</ref> <ref>PMID:15205584</ref> <ref>PMID:15617741</ref> Defects in F12 are the cause of hereditary angioedema type 3 (HAE3) [MIM:[~~http~~://omim.org/entry/610618 610618]]; also known as estrogen-related HAE or hereditary angioneurotic edema with normal C1 inhibitor concentration and function. HAE is characterized by episodic local subcutaneous edema, and submucosal edema involving the upper respiratory and gastrointestinal tracts. HAE3 occurs exclusively in women and is precipitated or worsened by high estrogen levels (e.g. during pregnancy or treatment with oral contraceptives). It differs from HAE types 1 and 2 in that both concentration and function of C1 inhibitor are normal.<ref>PMID:16638441</ref> <ref>PMID:17186468</ref>	+	[https://www.uniprot.org/uniprot/FA12_HUMAN FA12_HUMAN] Congenital factor XII deficiency;Hereditary angioedema type 3. Defects in F12 are the cause of factor XII deficiency (FA12D) [MIM:[https://omim.org/entry/234000 234000]; also known as Hageman factor deficiency. This trait is an asymptomatic anomaly of in vitro blood coagulation. Its diagnosis is based on finding a low plasma activity of the factor in coagulating assays. It is usually only accidentally discovered through pre-operative blood tests. F12 deficiency is divided into two categories, a cross-reacting material (CRM)-negative group (negative F12 antigen detection) and a CRM-positive group (positive F12 antigen detection).<ref>PMID:8528215</ref> <ref>PMID:2882793</ref> <ref>PMID:2510163</ref> <ref>PMID:8049433</ref> <ref>PMID:9354665</ref> <ref>PMID:10361128</ref> <ref>PMID:11776307</ref> <ref>PMID:15205584</ref> <ref>PMID:15617741</ref> Defects in F12 are the cause of hereditary angioedema type 3 (HAE3) [MIM:[https://omim.org/entry/610618 610618]; also known as estrogen-related HAE or hereditary angioneurotic edema with normal C1 inhibitor concentration and function. HAE is characterized by episodic local subcutaneous edema, and submucosal edema involving the upper respiratory and gastrointestinal tracts. HAE3 occurs exclusively in women and is precipitated or worsened by high estrogen levels (e.g. during pregnancy or treatment with oral contraceptives). It differs from HAE types 1 and 2 in that both concentration and function of C1 inhibitor are normal.<ref>PMID:16638441</ref> <ref>PMID:17186468</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/FA12_HUMAN FA12_HUMAN]] Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa.<ref>PMID:21304106</ref>	+	[https://www.uniprot.org/uniprot/FA12_HUMAN FA12_HUMAN] Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa.<ref>PMID:21304106</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 6b77" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6b77" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[3D structures of FXII\|3D structures of FXII]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Coagulation factor XIIa]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dementiev~~, A A~~]]	+	[[Category: Dementiev AA]]
-	[[Category: Flavin~~, M T~~]]	+	[[Category: Flavin MT]]
-	[[Category: Partridge~~, J R~~]]	+	[[Category: Partridge JR]]
-	[[Category: Silva, A]]	+	[[Category: Silva A]]
-	[[Category: Yee, C]]	+	[[Category: Yee C]]
-	~~[[Category: Blood clotting]]~~	+
-	~~[[Category: Structural characterization of human plasma factor xiia in complexes with inhibitor~~]]	+

OCA at 21:37, 28 October 2020

OCA — Wed, 28 Oct 2020 21:37:30 GMT

←Older revision		Revision as of 21:37, 28 October 2020
Line 1:		Line 1:

	==Structures of the two-chain human plasma factor XIIa co-crystallized with potent inhibitors==		==Structures of the two-chain human plasma factor XIIa co-crystallized with potent inhibitors==
-	<StructureSection load='6b77' size='340' side='right' caption='[[6b77]], [[Resolution\|resolution]] 2.37Å' scene=''>	+	<StructureSection load='6b77' size='340' side='right'caption='[[6b77]], [[Resolution\|resolution]] 2.37Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6b77]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B77 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6B77 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6b77]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B77 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6B77 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CWV:[3-(1-aminoisoquinolin-6-yl)phenyl]boronic+acid'>CWV</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=~~NAG~~:~~N-ACETYL-D-GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=~~SO4~~:~~SULFATE+ION~~'>~~SO4~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CWV:[3-(1-aminoisoquinolin-6-yl)phenyl]boronic+acid'>CWV</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6b74\|6b74]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6b74\|6b74]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_XIIa Coagulation factor XIIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.38 3.4.21.38] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_XIIa Coagulation factor XIIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.38 3.4.21.38] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6b77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b77 OCA], [http://pdbe.org/6b77 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b77 RCSB], [http://www.ebi.ac.uk/pdbsum/6b77 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b77 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6b77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b77 OCA], [http://pdbe.org/6b77 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b77 RCSB], [http://www.ebi.ac.uk/pdbsum/6b77 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b77 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 28:		Line 28:
	[[Category: Coagulation factor XIIa]]		[[Category: Coagulation factor XIIa]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
		+	[[Category: Large Structures]]
	[[Category: Dementiev, A A]]		[[Category: Dementiev, A A]]
	[[Category: Flavin, M T]]		[[Category: Flavin, M T]]

OCA at 07:39, 21 March 2018

OCA — Wed, 21 Mar 2018 07:39:01 GMT

←Older revision		Revision as of 07:39, 21 March 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6b77 is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Structures of the two-chain human plasma factor XIIa co-crystallized with potent inhibitors==
		+	<StructureSection load='6b77' size='340' side='right' caption='[[6b77]], [[Resolution\|resolution]] 2.37Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6b77]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B77 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B77 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CWV:[3-(1-aminoisoquinolin-6-yl)phenyl]boronic+acid'>CWV</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6b74\|6b74]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_XIIa Coagulation factor XIIa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.38 3.4.21.38] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b77 OCA], [http://pdbe.org/6b77 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b77 RCSB], [http://www.ebi.ac.uk/pdbsum/6b77 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b77 ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/FA12_HUMAN FA12_HUMAN]] Congenital factor XII deficiency;Hereditary angioedema type 3. Defects in F12 are the cause of factor XII deficiency (FA12D) [MIM:[http://omim.org/entry/234000 234000]]; also known as Hageman factor deficiency. This trait is an asymptomatic anomaly of in vitro blood coagulation. Its diagnosis is based on finding a low plasma activity of the factor in coagulating assays. It is usually only accidentally discovered through pre-operative blood tests. F12 deficiency is divided into two categories, a cross-reacting material (CRM)-negative group (negative F12 antigen detection) and a CRM-positive group (positive F12 antigen detection).<ref>PMID:8528215</ref> <ref>PMID:2882793</ref> <ref>PMID:2510163</ref> <ref>PMID:8049433</ref> <ref>PMID:9354665</ref> <ref>PMID:10361128</ref> <ref>PMID:11776307</ref> <ref>PMID:15205584</ref> <ref>PMID:15617741</ref> Defects in F12 are the cause of hereditary angioedema type 3 (HAE3) [MIM:[http://omim.org/entry/610618 610618]]; also known as estrogen-related HAE or hereditary angioneurotic edema with normal C1 inhibitor concentration and function. HAE is characterized by episodic local subcutaneous edema, and submucosal edema involving the upper respiratory and gastrointestinal tracts. HAE3 occurs exclusively in women and is precipitated or worsened by high estrogen levels (e.g. during pregnancy or treatment with oral contraceptives). It differs from HAE types 1 and 2 in that both concentration and function of C1 inhibitor are normal.<ref>PMID:16638441</ref> <ref>PMID:17186468</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FA12_HUMAN FA12_HUMAN]] Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa.<ref>PMID:21304106</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Activated factor XIIa (FXIIa) is a serine protease that has received a great deal of interest in recent years as a potential target for the development of new antithrombotics. Despite the strong interest in obtaining structural information, only the structure of the FXIIa catalytic domain in its zymogen conformation is available. In this work, reproducible experimental conditions found for the crystallization of human plasma beta-FXIIa and crystal growth optimization have led to determination of the first structure of the active form of the enzyme. Two crystal structures of human plasma beta-FXIIa complexed with small molecule inhibitors are presented herein. The first is the noncovalent inhibitor benzamidine. The second is an aminoisoquinoline containing a boronic acid-reactive group that targets the catalytic serine. Both benzamidine and the aminoisoquinoline bind in a canonical fashion typical of synthetic serine protease inhibitors, and the protease domain adopts a typical chymotrypsin-like serine protease active conformation. This novel structural data explains the basis of the FXII activation, provides insights into the enzymatic properties of beta-FXIIa, and is a great aid toward the further design of protease inhibitors for human FXIIa.

-	~~Authors: Dementiev~~, A~~.A.~~, Silva, A., Yee, C., Flavin, ~~M.T.~~, Partridge~~, J~~.R.	+	Structures of human plasma beta-factor XIIa cocrystallized with potent inhibitors.,Dementiev A, Silva A, Yee C, Li Z, Flavin MT, Sham H, Partridge JR Blood Adv. 2018 Mar 13;2(5):549-558. doi: 10.1182/bloodadvances.2018016337. PMID:29519898<ref>PMID:29519898</ref>

-	~~Description: Structures~~ of the ~~two~~-~~chain human plasma factor XIIa co~~-~~crystallized with potent inhibitors~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: ~~Flavin, M.T~~]]	+	<div class="pdbe-citations 6b77" style="background-color:#fffaf0;"></div>
-	[[Category: Dementiev, A.A]]	+	== References ==
-	[[Category: ~~Partridge~~, ~~J.R~~]]	+	<references/>
-	[[Category: ~~Yee~~, C]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Coagulation factor XIIa]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Dementiev, A A]]
		+	[[Category: Flavin, M T]]
		+	[[Category: Partridge, J R]]
	[[Category: Silva, A]]		[[Category: Silva, A]]
		+	[[Category: Yee, C]]
		+	[[Category: Blood clotting]]
		+	[[Category: Structural characterization of human plasma factor xiia in complexes with inhibitor]]

OCA at 04:51, 1 November 2017

OCA — Wed, 01 Nov 2017 04:51:47 GMT

←Older revision		Revision as of 04:51, 1 November 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6b77 is ON HOLD	+	The entry 6b77 is ON HOLD until Paper Publication

	Authors: Dementiev, A.A., Silva, A., Yee, C., Flavin, M.T., Partridge, J.R.		Authors: Dementiev, A.A., Silva, A., Yee, C., Flavin, M.T., Partridge, J.R.

OCA: Protected "6b77" [edit=sysop:move=sysop]

OCA — Wed, 11 Oct 2017 05:37:11 GMT

Protected "6b77" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:37, 11 October 2017

OCA: New page: '''Unreleased structure''' The entry 6b77 is ON HOLD Authors: Dementiev, A.A., Silva, A., Yee, C., Flavin, M.T., Partridge, J.R. Description: Structures of the two-chain human plasma f...

OCA — Wed, 11 Oct 2017 05:37:10 GMT

New page: '''Unreleased structure''' The entry 6b77 is ON HOLD Authors: Dementiev, A.A., Silva, A., Yee, C., Flavin, M.T., Partridge, J.R. Description: Structures of the two-chain human plasma f...

New page

'''Unreleased structure'''

The entry 6b77 is ON HOLD

Authors: Dementiev, A.A., Silva, A., Yee, C., Flavin, M.T., Partridge, J.R.

Description: Structures of the two-chain human plasma factor XIIa co-crystallized with potent inhibitors
[[Category: Unreleased Structures]]
[[Category: Flavin, M.T]]
[[Category: Dementiev, A.A]]
[[Category: Partridge, J.R]]
[[Category: Yee, C]]
[[Category: Silva, A]]