6bdx - Revision history

OCA at 14:38, 4 October 2023

OCA — Wed, 04 Oct 2023 14:38:57 GMT

←Older revision		Revision as of 14:38, 4 October 2023
Line 1:		Line 1:

	==4-hydroxy tetrahydrodipicolinate reductase from Neisseria gonorrhoeae==		==4-hydroxy tetrahydrodipicolinate reductase from Neisseria gonorrhoeae==
-	<StructureSection load='6bdx' size='340' side='right' caption='[[6bdx]], [[Resolution\|resolution]] 1.85Å' scene=''>	+	<StructureSection load='6bdx' size='340' side='right'caption='[[6bdx]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6bdx]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"diplococcus_gonorrhoeae"_(zopf_1885)_lehmann_and_neumann_1896 "diplococcus~~ gonorrhoeae~~" (zopf 1885) lehmann and neumann 1896~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BDX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6BDX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6bdx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BDX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BDX FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.85Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">dapB, WHOK_00270, WHOK_02229C, WHOM_00688, WHOM_02238C, WHOP_00630, WHOP_02238C, WHOU_00751, WHOU_02311C, WHOV_01184, WHOV_02299C, WHOW_00218, WHOW_02292C, WHOX_00871, WHOX_02228C, WHOY_00570, WHOY_02311C, WHOZ_01787, WHOZ_02300C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~485~~ "~~Diplococcus gonorrhoeae~~" ~~(Zopf 1885) Lehmann and Neumann 1896])</td~~><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>[http://en.wikipedia.org/wiki/4-hydroxy-tetrahydrodipicolinate_reductase 4-hydroxy-tetrahydrodipicolinate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.1.8 1.17.1.8] </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bdx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bdx OCA], [https://pdbe.org/6bdx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bdx RCSB], [https://www.ebi.ac.uk/pdbsum/6bdx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bdx ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6bdx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bdx OCA], [~~http~~://pdbe.org/6bdx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6bdx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6bdx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6bdx ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~A0A1D3EVW8_NEIGO A0A1D3EVW8_NEIGO]~~] Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.[HAMAP-Rule:MF_00102~~][SAAS:SAAS00011094~~]	+	[https://www.uniprot.org/uniprot/DAPB_NEIG1 DAPB_NEIG1] Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.[HAMAP-Rule:MF_00102]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~4-hydroxy-tetrahydrodipicolinate reductase]]~~	+	[[Category: Large Structures]]
-	~~[[Category: Chruszcz, M]]~~	+
-	~~[[Category: Pote, S S]]~~	+
-	~~[[Category: Pye, S E]]~~	+
-	~~[[Category: Sheahan, T E]]~~	+
-	~~[[Category: 4-hydroxy tetrahydrodipicolinate reductase]]~~	+
-	~~[[Category: Lysine biosynthesis~~]]	+
	[[Category: Neisseria gonorrhoeae]]		[[Category: Neisseria gonorrhoeae]]
-	[[Category: ~~Oxidoreductase~~]]	+	[[Category: Chruszcz M]]
		+	[[Category: Pote SS]]
		+	[[Category: Pye SE]]
		+	[[Category: Sheahan TE]]

OCA at 07:50, 12 September 2018

OCA — Wed, 12 Sep 2018 07:50:05 GMT

←Older revision		Revision as of 07:50, 12 September 2018
Line 3:		Line 3:
	<StructureSection load='6bdx' size='340' side='right' caption='[[6bdx]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='6bdx' size='340' side='right' caption='[[6bdx]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6bdx]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BDX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BDX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6bdx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"diplococcus_gonorrhoeae"_(zopf_1885)_lehmann_and_neumann_1896 "diplococcus gonorrhoeae" (zopf 1885) lehmann and neumann 1896]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BDX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BDX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dapB, WHOK_00270, WHOK_02229C, WHOM_00688, WHOM_02238C, WHOP_00630, WHOP_02238C, WHOU_00751, WHOU_02311C, WHOV_01184, WHOV_02299C, WHOW_00218, WHOW_02292C, WHOX_00871, WHOX_02228C, WHOY_00570, WHOY_02311C, WHOZ_01787, WHOZ_02300C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=485 "Diplococcus gonorrhoeae" (Zopf 1885) Lehmann and Neumann 1896])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxy-tetrahydrodipicolinate_reductase 4-hydroxy-tetrahydrodipicolinate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.1.8 1.17.1.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxy-tetrahydrodipicolinate_reductase 4-hydroxy-tetrahydrodipicolinate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.1.8 1.17.1.8] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bdx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bdx OCA], [http://pdbe.org/6bdx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bdx RCSB], [http://www.ebi.ac.uk/pdbsum/6bdx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bdx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bdx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bdx OCA], [http://pdbe.org/6bdx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bdx RCSB], [http://www.ebi.ac.uk/pdbsum/6bdx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bdx ProSAT]</span></td></tr>

OCA at 07:25, 29 August 2018

OCA — Wed, 29 Aug 2018 07:25:40 GMT

←Older revision		Revision as of 07:25, 29 August 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6bdx is ~~ON HOLD until Oct 24 2019~~	+	==4-hydroxy tetrahydrodipicolinate reductase from Neisseria gonorrhoeae==
		+	<StructureSection load='6bdx' size='340' side='right' caption='[[6bdx]], [[Resolution\|resolution]] 1.85Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6bdx]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BDX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BDX FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxy-tetrahydrodipicolinate_reductase 4-hydroxy-tetrahydrodipicolinate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.1.8 1.17.1.8] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bdx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bdx OCA], [http://pdbe.org/6bdx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bdx RCSB], [http://www.ebi.ac.uk/pdbsum/6bdx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bdx ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/A0A1D3EVW8_NEIGO A0A1D3EVW8_NEIGO]] Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.[HAMAP-Rule:MF_00102][SAAS:SAAS00011094]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Neisseria gonorrhoeae, an obligate human pathogen, is a leading cause of communicable diseases globally. Due to rapid development of drug resistance, the rate of successfully curing gonococcal infections is rapidly decreasing. Hence, research is being directed toward finding alternative drugs or drug targets to help eradicate these infections. 4-Hydroxy-tetrahydrodipicolinate reductase (DapB), an important enzyme in the meso-diaminopimelate pathway, is a promising target for the development of new antibiotics. This manuscript describes the first structure of DapB from N. gonorrhoeae determined at 1.85A. This enzyme uses NAD(P)H as cofactor. Details of the interactions of the enzyme with its cofactors and a substrate analog/inhibitor are discussed. A large scale bioinformatics analysis of DapBs' sequences is also described.

-	~~Authors: Pote~~, S~~.S.~~, Pye~~, S.E.~~, Sheahan, ~~T.E.,~~ Chruszcz, M.	+	4-Hydroxy-tetrahydrodipicolinate reductase from Neisseria gonorrhoeae - structure and interactions with coenzymes and substrate analog.,Pote S, Pye SE, Sheahan TE, Gawlicka-Chruszcz A, Majorek KA, Chruszcz M Biochem Biophys Res Commun. 2018 Aug 6. pii: S0006-291X(18)31651-6. doi:, 10.1016/j.bbrc.2018.07.147. PMID:30093108<ref>PMID:30093108</ref>

-	~~Description: 4-hydroxy tetrahydrodipicolinate reductase from Neisseria gonorrhoeae~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category: Sheahan~~, T.~~E]]~~	+	<div class="pdbe-citations 6bdx" style="background-color:#fffaf0;"></div>
-	~~[[Category: Pye,~~ S.~~E]]~~	+	== References ==
-	[[Category: ~~Pote, S.S~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: 4-hydroxy-tetrahydrodipicolinate reductase]]
	[[Category: Chruszcz, M]]		[[Category: Chruszcz, M]]
		+	[[Category: Pote, S S]]
		+	[[Category: Pye, S E]]
		+	[[Category: Sheahan, T E]]
		+	[[Category: 4-hydroxy tetrahydrodipicolinate reductase]]
		+	[[Category: Lysine biosynthesis]]
		+	[[Category: Neisseria gonorrhoeae]]
		+	[[Category: Oxidoreductase]]

OCA at 04:43, 31 January 2018

OCA — Wed, 31 Jan 2018 04:43:31 GMT

←Older revision		Revision as of 04:43, 31 January 2018
Line 3:		Line 3:
	The entry 6bdx is ON HOLD until Oct 24 2019		The entry 6bdx is ON HOLD until Oct 24 2019

-	Authors: Pote, S.P., Pye, S.E., Sheahan, T.E., Chruszcz, M.	+	Authors: Pote, S.S., Pye, S.E., Sheahan, T.E., Chruszcz, M.

	Description: 4-hydroxy tetrahydrodipicolinate reductase from Neisseria gonorrhoeae		Description: 4-hydroxy tetrahydrodipicolinate reductase from Neisseria gonorrhoeae
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Sheahan, T.E]]		[[Category: Sheahan, T.E]]
-	[[Category: Chruszcz, M]]
	[[Category: Pye, S.E]]		[[Category: Pye, S.E]]
-	[[Category: Pote, S.P]]	+	[[Category: Pote, S.S]]
		+	[[Category: Chruszcz, M]]

OCA at 05:03, 29 November 2017

OCA — Wed, 29 Nov 2017 05:03:03 GMT

←Older revision		Revision as of 05:03, 29 November 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6bdx is ON HOLD	+	The entry 6bdx is ON HOLD until Oct 24 2019

	Authors: Pote, S.P., Pye, S.E., Sheahan, T.E., Chruszcz, M.		Authors: Pote, S.P., Pye, S.E., Sheahan, T.E., Chruszcz, M.

OCA: Protected "6bdx" [edit=sysop:move=sysop]

OCA — Wed, 01 Nov 2017 04:58:13 GMT

Protected "6bdx" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:58, 1 November 2017

OCA: New page: '''Unreleased structure''' The entry 6bdx is ON HOLD Authors: Pote, S.P., Pye, S.E., Sheahan, T.E., Chruszcz, M. Description: 4-hydroxy tetrahydrodipicolinate reductase from Neisseria ...

OCA — Wed, 01 Nov 2017 04:58:12 GMT

New page: '''Unreleased structure''' The entry 6bdx is ON HOLD Authors: Pote, S.P., Pye, S.E., Sheahan, T.E., Chruszcz, M. Description: 4-hydroxy tetrahydrodipicolinate reductase from Neisseria ...

New page

'''Unreleased structure'''

The entry 6bdx is ON HOLD

Authors: Pote, S.P., Pye, S.E., Sheahan, T.E., Chruszcz, M.

Description: 4-hydroxy tetrahydrodipicolinate reductase from Neisseria gonorrhoeae
[[Category: Unreleased Structures]]
[[Category: Sheahan, T.E]]
[[Category: Chruszcz, M]]
[[Category: Pye, S.E]]
[[Category: Pote, S.P]]