6bkb - Revision history

OCA at 14:44, 4 October 2023

OCA — Wed, 04 Oct 2023 14:44:14 GMT

←Older revision		Revision as of 14:44, 4 October 2023
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	<StructureSection load='6bkb' size='340' side='right'caption='[[6bkb]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='6bkb' size='340' side='right'caption='[[6bkb]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6bkb]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~] and [~~http~~://en.wikipedia.org/wiki/~~Recombinant_hepatitis_c_virus_hk6a~~/~~jfh~~-1 Recombinant ~~hepatitis c~~ virus ~~hk6a~~/~~jfh~~-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BKB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6BKB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6bkb]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Recombinant_Hepatitis_C_virus_HK6a/JFH-1 Recombinant Hepatitis C virus HK6a/JFH-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BKB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BKB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.799Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6bkb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bkb OCA], [~~http~~://pdbe.org/6bkb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6bkb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6bkb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6bkb ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bkb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bkb OCA], [https://pdbe.org/6bkb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bkb RCSB], [https://www.ebi.ac.uk/pdbsum/6bkb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bkb ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/IGG1_HUMAN IGG1_HUMAN] Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).<ref>PMID:17576170</ref> <ref>PMID:20176268</ref> <ref>PMID:22158414</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 16:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 6bkb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6bkb" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Recombinant ~~hepatitis c~~ virus ~~hk6a~~/~~jfh~~-1]]	+	[[Category: Recombinant Hepatitis C virus HK6a/JFH-1]]
-	[[Category: Law, M]]	+	[[Category: Law M]]
-	[[Category: Tzarum, N]]	+	[[Category: Tzarum N]]
-	[[Category: Wilson~~, I A]]~~	+	[[Category: Wilson IA]]
-	~~[[Category: Bnab]]~~	+
-	~~[[Category: Broadly neutralizing antibody]]~~	+
-	~~[[Category: E2 core]]~~	+
-	~~[[Category: Hcv]]~~	+
-	~~[[Category: Ighv1-69]]~~	+
-	~~[[Category: Immune system~~]]	+

OCA at 22:59, 5 June 2019

OCA — Wed, 05 Jun 2019 22:59:07 GMT

←Older revision		Revision as of 22:59, 5 June 2019
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	==Structure of Hepatitis C Virus Envelope Glycoprotein E2 core from genotype 6a bound to broadly neutralizing antibody AR3A==		==Structure of Hepatitis C Virus Envelope Glycoprotein E2 core from genotype 6a bound to broadly neutralizing antibody AR3A==
-	<StructureSection load='6bkb' size='340' side='right' caption='[[6bkb]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='6bkb' size='340' side='right'caption='[[6bkb]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6bkb]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BKB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BKB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6bkb]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Recombinant_hepatitis_c_virus_hk6a/jfh-1 Recombinant hepatitis c virus hk6a/jfh-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BKB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BKB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bkb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bkb OCA], [http://pdbe.org/6bkb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bkb RCSB], [http://www.ebi.ac.uk/pdbsum/6bkb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bkb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bkb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bkb OCA], [http://pdbe.org/6bkb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bkb RCSB], [http://www.ebi.ac.uk/pdbsum/6bkb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bkb ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	An effective vaccine to the antigenically diverse hepatitis C virus (HCV) must target conserved immune epitopes. Here, we investigate cross-neutralization of HCV genotypes by broadly neutralizing antibodies (bNAbs) encoded by the relatively abundant human gene family V H 1-69. We have deciphered the molecular requirements for cross-neutralization by this unique class of human antibodies from crystal structures of HCV E2 in complex with bNAbs. An unusually high binding affinity is found for germ line-reverted versions of VH1-69 precursor antibodies, and neutralization breadth is acquired during affinity maturation. Deep sequencing analysis of an HCV-immune B cell repertoire further demonstrates the importance of the V H 1-69 gene family in the generation of HCV bNAbs. This study therefore provides critical insights into immune recognition of HCV with important implications for rational vaccine design.
		+
		+	Genetic and structural insights into broad neutralization of hepatitis C virus by human VH1-69 antibodies.,Tzarum N, Giang E, Kong L, He L, Prentoe J, Augestad E, Hua Y, Castillo S, Lauer GM, Bukh J, Zhu J, Wilson IA, Law M Sci Adv. 2019 Jan 2;5(1):eaav1882. doi: 10.1126/sciadv.aav1882. eCollection 2019 , Jan. PMID:30613781<ref>PMID:30613781</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6bkb" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
		+	[[Category: Recombinant hepatitis c virus hk6a/jfh-1]]
	[[Category: Law, M]]		[[Category: Law, M]]
	[[Category: Tzarum, N]]		[[Category: Tzarum, N]]

OCA at 08:15, 26 December 2018

OCA — Wed, 26 Dec 2018 08:15:01 GMT

←Older revision		Revision as of 08:15, 26 December 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6bkb is ~~ON HOLD until Paper Publication~~	+	==Structure of Hepatitis C Virus Envelope Glycoprotein E2 core from genotype 6a bound to broadly neutralizing antibody AR3A==
-		+	<StructureSection load='6bkb' size='340' side='right' caption='[[6bkb]], [[Resolution\|resolution]] 2.80Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6bkb]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BKB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BKB FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bkb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bkb OCA], [http://pdbe.org/6bkb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bkb RCSB], [http://www.ebi.ac.uk/pdbsum/6bkb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bkb ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Law, M]]
		+	[[Category: Tzarum, N]]
		+	[[Category: Wilson, I A]]
		+	[[Category: Bnab]]
		+	[[Category: Broadly neutralizing antibody]]
		+	[[Category: E2 core]]
		+	[[Category: Hcv]]
		+	[[Category: Ighv1-69]]
		+	[[Category: Immune system]]

OCA at 05:05, 31 October 2018

OCA — Wed, 31 Oct 2018 05:05:45 GMT

←Older revision		Revision as of 05:05, 31 October 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6bkb is ON HOLD	+	The entry 6bkb is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 06:08, 17 October 2018

OCA — Wed, 17 Oct 2018 06:08:32 GMT

←Older revision		Revision as of 06:08, 17 October 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6bkb is ON HOLD ~~until Paper Publication~~	+	The entry 6bkb is ON HOLD

	Authors:		Authors:

OCA at 05:39, 17 January 2018

OCA — Wed, 17 Jan 2018 05:39:05 GMT

←Older revision		Revision as of 05:39, 17 January 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6bkb is ON HOLD	+	The entry 6bkb is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6bkb" [edit=sysop:move=sysop]

OCA — Wed, 15 Nov 2017 06:24:43 GMT

Protected "6bkb" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:24, 15 November 2017

OCA: New page: '''Unreleased structure''' The entry 6bkb is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 15 Nov 2017 06:24:42 GMT

New page: '''Unreleased structure''' The entry 6bkb is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6bkb is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]