6bmn - Revision history

OCA at 08:27, 22 February 2018

OCA — Thu, 22 Feb 2018 08:27:52 GMT

←Older revision		Revision as of 08:27, 22 February 2018
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	<StructureSection load='6bmn' size='340' side='right' caption='[[6bmn]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='6bmn' size='340' side='right' caption='[[6bmn]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6bmn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BMN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BMN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6bmn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BMN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BMN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PAP:3-PHOSPHATE-ADENOSINE-5-DIPHOSPHATE'>PAP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PAP:3-PHOSPHATE-ADENOSINE-5-DIPHOSPHATE'>PAP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ZDHHC20 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_S-acyltransferase Protein S-acyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.225 2.3.1.225] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_S-acyltransferase Protein S-acyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.225 2.3.1.225] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bmn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bmn OCA], [http://pdbe.org/6bmn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bmn RCSB], [http://www.ebi.ac.uk/pdbsum/6bmn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bmn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bmn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bmn OCA], [http://pdbe.org/6bmn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bmn RCSB], [http://www.ebi.ac.uk/pdbsum/6bmn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bmn ProSAT]</span></td></tr>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Protein S-acyltransferase]]		[[Category: Protein S-acyltransferase]]
	[[Category: Banerjee, A]]		[[Category: Banerjee, A]]

OCA at 18:29, 24 January 2018

OCA — Wed, 24 Jan 2018 18:29:59 GMT

←Older revision		Revision as of 18:29, 24 January 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6bmn is ~~ON HOLD until Paper~~ Publication	+	==Structure of human DHHC20 palmitoyltransferase, space group P63==
		+	<StructureSection load='6bmn' size='340' side='right' caption='[[6bmn]], [[Resolution\|resolution]] 2.25Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6bmn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BMN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BMN FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PAP:3-PHOSPHATE-ADENOSINE-5-DIPHOSPHATE'>PAP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_S-acyltransferase Protein S-acyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.225 2.3.1.225] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bmn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bmn OCA], [http://pdbe.org/6bmn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bmn RCSB], [http://www.ebi.ac.uk/pdbsum/6bmn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bmn ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	DHHC (Asp-His-His-Cys) palmitoyltransferases are eukaryotic integral membrane enzymes that catalyze protein palmitoylation, which is important in a range of physiological processes, including small guanosine triphosphatase (GTPase) signaling, cell adhesion, and neuronal receptor scaffolding. We present crystal structures of two DHHC palmitoyltransferases and a covalent intermediate mimic. The active site resides at the membrane-cytosol interface, which allows the enzyme to catalyze thioester-exchange chemistry by using fatty acyl-coenzyme A and explains why membrane-proximal cysteines are candidates for palmitoylation. The acyl chain binds in a cavity formed by the transmembrane domain. We propose a mechanism for acyl chain-length selectivity in DHHC enzymes on the basis of cavity mutants with preferences for shorter and longer acyl chains.

-	~~Authors:~~ Lee, C.-J.	+	Fatty acyl recognition and transfer by an integral membrane S-acyltransferase.,Rana MS, Kumar P, Lee CJ, Verardi R, Rajashankar KR, Banerjee A Science. 2018 Jan 12;359(6372). pii: 359/6372/eaao6326. doi:, 10.1126/science.aao6326. PMID:29326245<ref>PMID:29326245</ref>

-	~~Description~~: ~~lipid binding enzyme p63~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: Lee, C.-J]]	+	<div class="pdbe-citations 6bmn" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Protein S-acyltransferase]]
		+	[[Category: Banerjee, A]]
		+	[[Category: Lee, C J]]
		+	[[Category: Rana, M S]]
		+	[[Category: Acyl]]
		+	[[Category: Dhhc]]
		+	[[Category: Lipid]]
		+	[[Category: Palmitoyltransferase]]
		+	[[Category: Transferase]]

OCA at 07:17, 27 December 2017

OCA — Wed, 27 Dec 2017 07:17:07 GMT

←Older revision		Revision as of 07:17, 27 December 2017
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6bmn is ON HOLD	+	The entry 6bmn is ON HOLD until Paper Publication

	Authors: Lee, C.-J.		Authors: Lee, C.-J.

OCA at 06:03, 6 December 2017

OCA — Wed, 06 Dec 2017 06:03:38 GMT

←Older revision		Revision as of 06:03, 6 December 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6bmn is ON HOLD ~~until sometime in the future~~	+	The entry 6bmn is ON HOLD

	Authors: Lee, C.-J.		Authors: Lee, C.-J.

OCA at 05:04, 29 November 2017

OCA — Wed, 29 Nov 2017 05:04:27 GMT

←Older revision		Revision as of 05:04, 29 November 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6bmn is ON HOLD	+	The entry 6bmn is ON HOLD until sometime in the future

	Authors: Lee, C.-J.		Authors: Lee, C.-J.

OCA: Protected "6bmn" [edit=sysop:move=sysop]

OCA — Wed, 22 Nov 2017 06:37:08 GMT

Protected "6bmn" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:37, 22 November 2017

OCA: New page: '''Unreleased structure''' The entry 6bmn is ON HOLD Authors: Lee, C.-J. Description: lipid binding enzyme p63 Category: Unreleased Structures Category: Lee, C.-J

OCA — Wed, 22 Nov 2017 06:37:07 GMT

New page: '''Unreleased structure''' The entry 6bmn is ON HOLD Authors: Lee, C.-J. Description: lipid binding enzyme p63 Category: Unreleased Structures Category: Lee, C.-J

New page

'''Unreleased structure'''

The entry 6bmn is ON HOLD

Authors: Lee, C.-J.

Description: lipid binding enzyme p63
[[Category: Unreleased Structures]]
[[Category: Lee, C.-J]]