6bob - Revision history

OCA at 14:23, 13 March 2024

OCA — Wed, 13 Mar 2024 14:23:11 GMT

←Older revision		Revision as of 14:23, 13 March 2024
Line 3:		Line 3:
	<SX load='6bob' size='340' side='right' viewer='molstar' caption='[[6bob]], [[Resolution\|resolution]] 3.90Å' scene=''>		<SX load='6bob' size='340' side='right' viewer='molstar' caption='[[6bob]], [[Resolution\|resolution]] 3.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6bob]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BOB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6BOB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6bob]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BOB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BOB FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~Trpv6 (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=10116 Buffalo rat])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.9Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6bob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bob OCA], [~~http~~://pdbe.org/6bob PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6bob RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6bob PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6bob ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bob OCA], [https://pdbe.org/6bob PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bob RCSB], [https://www.ebi.ac.uk/pdbsum/6bob PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bob ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TRPV6_RAT TRPV6_RAT]] Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).[UniProtKB:Q91WD2][UniProtKB:Q9H1D0]<ref>PMID:11287959</ref>	+	[https://www.uniprot.org/uniprot/TRPV6_RAT TRPV6_RAT] Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).[UniProtKB:Q91WD2][UniProtKB:Q9H1D0]<ref>PMID:11287959</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Calcium-selective transient receptor potential vanilloid subfamily member 6 (TRPV6) channels play a critical role in calcium uptake in epithelial tissues. Altered TRPV6 expression is associated with a variety of human diseases, including cancers. TRPV6 channels are constitutively active and their open probability depends on the lipidic composition of the membrane in which they reside; it increases substantially in the presence of phosphatidylinositol 4,5-bisphosphate. Crystal structures of detergent-solubilized rat TRPV6 in the closed state have previously been solved. Corroborating electrophysiological results, these structures demonstrated that the Ca(2+) selectivity of TRPV6 arises from a ring of aspartate side chains in the selectivity filter that binds Ca(2+) tightly. However, how TRPV6 channels open and close their pores for ion permeation has remained unclear. Here we present cryo-electron microscopy structures of human TRPV6 in the open and closed states. The channel selectivity filter adopts similar conformations in both states, consistent with its explicit role in ion permeation. The iris-like channel opening is accompanied by an alpha-to-pi-helical transition in the pore-lining transmembrane helix S6 at an alanine hinge just below the selectivity filter. As a result of this transition, the S6 helices bend and rotate, exposing different residues to the ion channel pore in the open and closed states. This gating mechanism, which defines the constitutive activity of TRPV6, is, to our knowledge, unique among tetrameric ion channels and provides structural insights for understanding their diverse roles in physiology and disease.	+

-	Opening of the human epithelial calcium channel TRPV6.,McGoldrick LL, Singh AK, Saotome K, Yelshanskaya MV, Twomey EC, Grassucci RA, Sobolevsky AI Nature. 2017 Dec 20. pii: nature25182. doi: 10.1038/nature25182. PMID:29258289<ref>PMID:29258289</ref>	+	==See Also==
-		+	*[[Ion channels 3D structures\|Ion channels 3D structures]]
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class~~=~~"pdbe-citations 6bob" style~~=~~"background-color:#fffaf0;"></div>~~	+
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</SX>		</SX>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Grassucci~~, R A~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: McGoldrick~~, L L~~]]	+	[[Category: Grassucci RA]]
-	[[Category: Saotome, K]]	+	[[Category: McGoldrick LL]]
-	[[Category: Singh~~, A K~~]]	+	[[Category: Saotome K]]
-	[[Category: Sobolevsky~~, A I~~]]	+	[[Category: Singh AK]]
-	[[Category: Twomey~~, E C~~]]	+	[[Category: Sobolevsky AI]]
-	[[Category: Yelshanskaya~~, M V]]~~	+	[[Category: Twomey EC]]
-	~~[[Category: Ion channel]]~~	+	[[Category: Yelshanskaya MV]]
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 23:26, 10 April 2020

OCA — Fri, 10 Apr 2020 23:26:35 GMT

←Older revision		Revision as of 23:26, 10 April 2020
Line 3:		Line 3:
	<SX load='6bob' size='340' side='right' viewer='molstar' caption='[[6bob]], [[Resolution\|resolution]] 3.90Å' scene=''>		<SX load='6bob' size='340' side='right' viewer='molstar' caption='[[6bob]], [[Resolution\|resolution]] 3.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6bob]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BOB OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6BOB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6bob]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BOB OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6BOB FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Trpv6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Trpv6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6bob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bob OCA], [http://pdbe.org/6bob PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bob RCSB], [http://www.ebi.ac.uk/pdbsum/6bob PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bob ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6bob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bob OCA], [http://pdbe.org/6bob PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bob RCSB], [http://www.ebi.ac.uk/pdbsum/6bob PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bob ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 20:33, 6 March 2020

OCA — Fri, 06 Mar 2020 20:33:19 GMT

←Older revision		Revision as of 20:33, 6 March 2020
Line 1:		Line 1:

	==Cryo-EM structure of rat TRPV6* in nanodiscs==		==Cryo-EM structure of rat TRPV6* in nanodiscs==
-	<~~StructureSection~~ load='6bob' size='340' side='right'caption='[[6bob]], [[Resolution\|resolution]] 3.90Å' scene=''>	+	<SX load='6bob' size='340' side='right' viewer='molstar' caption='[[6bob]], [[Resolution\|resolution]] 3.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6bob]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BOB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BOB FirstGlance]. <br>		<table><tr><td colspan='2'>[[6bob]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BOB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BOB FirstGlance]. <br>
Line 21:		Line 21:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 09:54, 4 December 2019

OCA — Wed, 04 Dec 2019 09:54:01 GMT

←Older revision		Revision as of 09:54, 4 December 2019
Line 1:		Line 1:

	==Cryo-EM structure of rat TRPV6* in nanodiscs==		==Cryo-EM structure of rat TRPV6* in nanodiscs==
-	<StructureSection load='6bob' size='340' side='right' caption='[[6bob]], [[Resolution\|resolution]] 3.90Å' scene=''>	+	<StructureSection load='6bob' size='340' side='right'caption='[[6bob]], [[Resolution\|resolution]] 3.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6bob]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BOB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BOB FirstGlance]. <br>		<table><tr><td colspan='2'>[[6bob]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BOB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BOB FirstGlance]. <br>
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Grassucci, R A]]		[[Category: Grassucci, R A]]
	[[Category: McGoldrick, L L]]		[[Category: McGoldrick, L L]]

OCA at 06:04, 3 January 2018

OCA — Wed, 03 Jan 2018 06:04:46 GMT

←Older revision		Revision as of 06:04, 3 January 2018
Line 3:		Line 3:
	<StructureSection load='6bob' size='340' side='right' caption='[[6bob]], [[Resolution\|resolution]] 3.90Å' scene=''>		<StructureSection load='6bob' size='340' side='right' caption='[[6bob]], [[Resolution\|resolution]] 3.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6bob]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BOB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BOB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6bob]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BOB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BOB FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bob OCA], [http://pdbe.org/6bob PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bob RCSB], [http://www.ebi.ac.uk/pdbsum/6bob PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bob ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Trpv6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bob OCA], [http://pdbe.org/6bob PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bob RCSB], [http://www.ebi.ac.uk/pdbsum/6bob PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bob ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/TRPV6_RAT TRPV6_RAT]] Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).[UniProtKB:Q91WD2][UniProtKB:Q9H1D0]<ref>PMID:11287959</ref>		[[http://www.uniprot.org/uniprot/TRPV6_RAT TRPV6_RAT]] Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).[UniProtKB:Q91WD2][UniProtKB:Q9H1D0]<ref>PMID:11287959</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Calcium-selective transient receptor potential vanilloid subfamily member 6 (TRPV6) channels play a critical role in calcium uptake in epithelial tissues. Altered TRPV6 expression is associated with a variety of human diseases, including cancers. TRPV6 channels are constitutively active and their open probability depends on the lipidic composition of the membrane in which they reside; it increases substantially in the presence of phosphatidylinositol 4,5-bisphosphate. Crystal structures of detergent-solubilized rat TRPV6 in the closed state have previously been solved. Corroborating electrophysiological results, these structures demonstrated that the Ca(2+) selectivity of TRPV6 arises from a ring of aspartate side chains in the selectivity filter that binds Ca(2+) tightly. However, how TRPV6 channels open and close their pores for ion permeation has remained unclear. Here we present cryo-electron microscopy structures of human TRPV6 in the open and closed states. The channel selectivity filter adopts similar conformations in both states, consistent with its explicit role in ion permeation. The iris-like channel opening is accompanied by an alpha-to-pi-helical transition in the pore-lining transmembrane helix S6 at an alanine hinge just below the selectivity filter. As a result of this transition, the S6 helices bend and rotate, exposing different residues to the ion channel pore in the open and closed states. This gating mechanism, which defines the constitutive activity of TRPV6, is, to our knowledge, unique among tetrameric ion channels and provides structural insights for understanding their diverse roles in physiology and disease.
		+
		+	Opening of the human epithelial calcium channel TRPV6.,McGoldrick LL, Singh AK, Saotome K, Yelshanskaya MV, Twomey EC, Grassucci RA, Sobolevsky AI Nature. 2017 Dec 20. pii: nature25182. doi: 10.1038/nature25182. PMID:29258289<ref>PMID:29258289</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6bob" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Buffalo rat]]
	[[Category: Grassucci, R A]]		[[Category: Grassucci, R A]]
	[[Category: McGoldrick, L L]]		[[Category: McGoldrick, L L]]

OCA at 06:25, 20 December 2017

OCA — Wed, 20 Dec 2017 06:25:28 GMT

←Older revision		Revision as of 06:25, 20 December 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6bob is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Cryo-EM structure of rat TRPV6* in nanodiscs==
-		+	<StructureSection load='6bob' size='340' side='right' caption='[[6bob]], [[Resolution\|resolution]] 3.90Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6bob]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BOB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BOB FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bob OCA], [http://pdbe.org/6bob PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bob RCSB], [http://www.ebi.ac.uk/pdbsum/6bob PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bob ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TRPV6_RAT TRPV6_RAT]] Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).[UniProtKB:Q91WD2][UniProtKB:Q9H1D0]<ref>PMID:11287959</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Grassucci, R A]]
		+	[[Category: McGoldrick, L L]]
		+	[[Category: Saotome, K]]
		+	[[Category: Singh, A K]]
		+	[[Category: Sobolevsky, A I]]
		+	[[Category: Twomey, E C]]
		+	[[Category: Yelshanskaya, M V]]
		+	[[Category: Ion channel]]
		+	[[Category: Membrane protein]]
		+	[[Category: Transport protein]]

OCA at 06:04, 6 December 2017

OCA — Wed, 06 Dec 2017 06:04:14 GMT

←Older revision		Revision as of 06:04, 6 December 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6bob is ON HOLD	+	The entry 6bob is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6bob" [edit=sysop:move=sysop]

OCA — Wed, 29 Nov 2017 05:06:53 GMT

Protected "6bob" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:06, 29 November 2017

OCA: New page: '''Unreleased structure''' The entry 6bob is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 29 Nov 2017 05:06:51 GMT

New page: '''Unreleased structure''' The entry 6bob is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6bob is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]