6bq1 - Revision history

OCA at 14:23, 13 March 2024

OCA — Wed, 13 Mar 2024 14:23:28 GMT

←Older revision		Revision as of 14:23, 13 March 2024
Line 3:		Line 3:
	<SX load='6bq1' size='340' side='right' viewer='molstar' caption='[[6bq1]], [[Resolution\|resolution]] 3.60Å' scene=''>		<SX load='6bq1' size='340' side='right' viewer='molstar' caption='[[6bq1]], [[Resolution\|resolution]] 3.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6bq1]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BQ1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6BQ1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6bq1]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BQ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BQ1 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=E4S:5-{2-amino-1-~~[~~4-(morpholin-4-yl)phenyl]-1H-benzimidazol-6-yl}-N-(2-fluorophenyl)-2-methoxypyridine-3-sulfonamide'>E4S</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.6Å</td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>~~[~~[Non-Standard_Residue~~\|~~NonStd Res:~~]]~~</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E4S:5-{2-amino-1-[4-(morpholin-4-yl)phenyl]-1H-benzimidazol-6-yl}-N-(2-fluorophenyl)-2-methoxypyridine-3-sulfonamide'>E4S</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>PI4KA, PIK4, PIK4CA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=9606 HUMAN]), TTC7B, TTC7L1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), FAM126A, DRCTNNB1A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bq1 OCA], [https://pdbe.org/6bq1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bq1 RCSB], [https://www.ebi.ac.uk/pdbsum/6bq1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bq1 ProSAT]</span></td></tr>
-	~~<tr id='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[http~~:~~//en.wikipedia.org/wiki/1~~-~~phosphatidylinositol_4~~-~~kinase~~ 1-~~phosphatidylinositol~~ 4-~~kinase~~]~~, with EC number [http://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=~~2~~.7.1.67~~ 2~~.7.1.67]~~ </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6bq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bq1 OCA], [~~http~~://pdbe.org/6bq1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6bq1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6bq1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6bq1 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/~~HYCCI_HUMAN HYCCI_HUMAN~~]~~] Hypomyelination~~ - ~~congenital cataract~~. The disease is caused by ~~mutations~~ affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/PI4KA_HUMAN PI4KA_HUMAN] Bilateral perisylvian polymicrogyria;Autosomal recessive spastic paraplegia type 84;Combined immunodeficiency-enteropathy spectrum. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~HYCCI_HUMAN HYCCI_HUMAN~~]~~] May have a role~~ in the ~~beta-catenin/Lef signaling pathway. May have a role~~ in the ~~process of myelination~~ of the ~~central and peripheral nervous system~~.<ref>PMID:~~16951682~~</ref>	+	[https://www.uniprot.org/uniprot/PI4KA_HUMAN PI4KA_HUMAN] Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate.<ref>PMID:10101268</ref> <ref>PMID:23229899</ref>
-	<~~div style="background-color~~:~~#fffaf0;"~~>	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Plasma membrane (PM) phosphoinositides play essential roles in cell physiology, serving as both markers of membrane identity and signaling molecules central to the cell's interaction with its environment. The first step in PM phosphoinositide synthesis is the conversion of phosphatidylinositol (PI) to PI4P, the precursor of PI(4,5)P2 and PI(3,4,5)P3 This conversion is catalyzed by the PI4KIIIalpha complex, comprising a lipid kinase, PI4KIIIalpha, and two regulatory subunits, TTC7 and FAM126. We here report the structure of this complex at 3.6-A resolution, determined by cryo-electron microscopy. The proteins form an obligate approximately 700-kDa superassembly with a broad surface suitable for membrane interaction, toward which the kinase active sites are oriented. The structural complexity of the assembly highlights PI4P synthesis as a major regulatory junction in PM phosphoinositide homeostasis. Our studies provide a framework for further exploring the mechanisms underlying PM phosphoinositide regulation.	+

-	Architecture of the human PI4KIIIalpha lipid kinase complex.,Lees JA, Zhang Y, Oh MS, Schauder CM, Yu X, Baskin JM, Dobbs K, Notarangelo LD, De Camilli P, Walz T, Reinisch KM Proc Natl Acad Sci U S A. 2017 Dec 11. pii: 1718471115. doi:, 10.1073/pnas.1718471115. PMID:29229838<ref>PMID:29229838</ref>	+	==See Also==
-		+	*[[Phosphatidylinositol 4-kinase\|Phosphatidylinositol 4-kinase]]
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class~~=~~"pdbe-citations 6bq1" style~~=~~"background~~-~~color:#fffaf0;"></div>~~	+
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</SX>		</SX>
-	[[Category: ~~1-phosphatidylinositol 4-kinase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Baskin, J]]	+	[[Category: Baskin J]]
-	[[Category: Camilli~~, P D~~]]	+	[[Category: Camilli PD]]
-	[[Category: Dobbs, K]]	+	[[Category: Dobbs K]]
-	[[Category: Lees~~, J A~~]]	+	[[Category: Lees JA]]
-	[[Category: Notarangelo~~, L D~~]]	+	[[Category: Notarangelo LD]]
-	[[Category: Oh, M]]	+	[[Category: Oh M]]
-	[[Category: Reinisch~~, K M~~]]	+	[[Category: Reinisch KM]]
-	[[Category: Schauder~~, C M~~]]	+	[[Category: Schauder CM]]
-	[[Category: Walz, T]]	+	[[Category: Walz T]]
-	[[Category: Yu, X]]	+	[[Category: Yu X]]
-	[[Category: Zhang, Y]]	+	[[Category: Zhang Y]]
-	~~[[Category: Kinase]]~~	+
-	~~[[Category: Phosphoinositide synthesis]]~~	+
-	~~[[Category: Transferase-signaling protein complex~~]]	+

OCA at 23:27, 10 April 2020

OCA — Fri, 10 Apr 2020 23:27:32 GMT

←Older revision		Revision as of 23:27, 10 April 2020
Line 3:		Line 3:
	<SX load='6bq1' size='340' side='right' viewer='molstar' caption='[[6bq1]], [[Resolution\|resolution]] 3.60Å' scene=''>		<SX load='6bq1' size='340' side='right' viewer='molstar' caption='[[6bq1]], [[Resolution\|resolution]] 3.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6bq1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BQ1 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6BQ1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6bq1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BQ1 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6BQ1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=E4S:5-{2-amino-1-[4-(morpholin-4-yl)phenyl]-1H-benzimidazol-6-yl}-N-(2-fluorophenyl)-2-methoxypyridine-3-sulfonamide'>E4S</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E4S:5-{2-amino-1-[4-(morpholin-4-yl)phenyl]-1H-benzimidazol-6-yl}-N-(2-fluorophenyl)-2-methoxypyridine-3-sulfonamide'>E4S</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PI4KA, PIK4, PIK4CA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), TTC7B, TTC7L1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), FAM126A, DRCTNNB1A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PI4KA, PIK4, PIK4CA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), TTC7B, TTC7L1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), FAM126A, DRCTNNB1A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1-phosphatidylinositol_4-kinase 1-phosphatidylinositol 4-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.67 2.7.1.67] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1-phosphatidylinositol_4-kinase 1-phosphatidylinositol 4-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.67 2.7.1.67] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6bq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bq1 OCA], [http://pdbe.org/6bq1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bq1 RCSB], [http://www.ebi.ac.uk/pdbsum/6bq1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bq1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6bq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bq1 OCA], [http://pdbe.org/6bq1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bq1 RCSB], [http://www.ebi.ac.uk/pdbsum/6bq1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bq1 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 20:33, 6 March 2020

OCA — Fri, 06 Mar 2020 20:33:44 GMT

←Older revision		Revision as of 20:33, 6 March 2020
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	==Human PI4KIIIa lipid kinase complex==		==Human PI4KIIIa lipid kinase complex==
-	<~~StructureSection~~ load='6bq1' size='340' side='right'caption='[[6bq1]], [[Resolution\|resolution]] 3.60Å' scene=''>	+	<SX load='6bq1' size='340' side='right' viewer='molstar' caption='[[6bq1]], [[Resolution\|resolution]] 3.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6bq1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BQ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BQ1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[6bq1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BQ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BQ1 FirstGlance]. <br>
Line 26:		Line 26:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: 1-phosphatidylinositol 4-kinase]]		[[Category: 1-phosphatidylinositol 4-kinase]]
	[[Category: Human]]		[[Category: Human]]

OCA at 09:22, 18 December 2019

OCA — Wed, 18 Dec 2019 09:22:55 GMT

←Older revision		Revision as of 09:22, 18 December 2019
Line 1:		Line 1:

	==Human PI4KIIIa lipid kinase complex==		==Human PI4KIIIa lipid kinase complex==
-	<StructureSection load='6bq1' size='340' side='right' caption='[[6bq1]], [[Resolution\|resolution]] 3.60Å' scene=''>	+	<StructureSection load='6bq1' size='340' side='right'caption='[[6bq1]], [[Resolution\|resolution]] 3.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6bq1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BQ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BQ1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[6bq1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BQ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BQ1 FirstGlance]. <br>
Line 29:		Line 29:
	[[Category: 1-phosphatidylinositol 4-kinase]]		[[Category: 1-phosphatidylinositol 4-kinase]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Baskin, J]]		[[Category: Baskin, J]]
	[[Category: Camilli, P D]]		[[Category: Camilli, P D]]

OCA at 09:01, 27 December 2017

OCA — Wed, 27 Dec 2017 09:01:02 GMT

←Older revision		Revision as of 09:01, 27 December 2017
Line 3:		Line 3:
	<StructureSection load='6bq1' size='340' side='right' caption='[[6bq1]], [[Resolution\|resolution]] 3.60Å' scene=''>		<StructureSection load='6bq1' size='340' side='right' caption='[[6bq1]], [[Resolution\|resolution]] 3.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6bq1]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BQ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BQ1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6bq1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BQ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BQ1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=E4S:5-{2-amino-1-[4-(morpholin-4-yl)phenyl]-1H-benzimidazol-6-yl}-N-(2-fluorophenyl)-2-methoxypyridine-3-sulfonamide'>E4S</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=E4S:5-{2-amino-1-[4-(morpholin-4-yl)phenyl]-1H-benzimidazol-6-yl}-N-(2-fluorophenyl)-2-methoxypyridine-3-sulfonamide'>E4S</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PI4KA, PIK4, PIK4CA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), TTC7B, TTC7L1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), FAM126A, DRCTNNB1A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1-phosphatidylinositol_4-kinase 1-phosphatidylinositol 4-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.67 2.7.1.67] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1-phosphatidylinositol_4-kinase 1-phosphatidylinositol 4-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.67 2.7.1.67] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bq1 OCA], [http://pdbe.org/6bq1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bq1 RCSB], [http://www.ebi.ac.uk/pdbsum/6bq1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bq1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bq1 OCA], [http://pdbe.org/6bq1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bq1 RCSB], [http://www.ebi.ac.uk/pdbsum/6bq1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bq1 ProSAT]</span></td></tr>
Line 13:		Line 14:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/HYCCI_HUMAN HYCCI_HUMAN]] May have a role in the beta-catenin/Lef signaling pathway. May have a role in the process of myelination of the central and peripheral nervous system.<ref>PMID:16951682</ref>		[[http://www.uniprot.org/uniprot/HYCCI_HUMAN HYCCI_HUMAN]] May have a role in the beta-catenin/Lef signaling pathway. May have a role in the process of myelination of the central and peripheral nervous system.<ref>PMID:16951682</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Plasma membrane (PM) phosphoinositides play essential roles in cell physiology, serving as both markers of membrane identity and signaling molecules central to the cell's interaction with its environment. The first step in PM phosphoinositide synthesis is the conversion of phosphatidylinositol (PI) to PI4P, the precursor of PI(4,5)P2 and PI(3,4,5)P3 This conversion is catalyzed by the PI4KIIIalpha complex, comprising a lipid kinase, PI4KIIIalpha, and two regulatory subunits, TTC7 and FAM126. We here report the structure of this complex at 3.6-A resolution, determined by cryo-electron microscopy. The proteins form an obligate approximately 700-kDa superassembly with a broad surface suitable for membrane interaction, toward which the kinase active sites are oriented. The structural complexity of the assembly highlights PI4P synthesis as a major regulatory junction in PM phosphoinositide homeostasis. Our studies provide a framework for further exploring the mechanisms underlying PM phosphoinositide regulation.
		+
		+	Architecture of the human PI4KIIIalpha lipid kinase complex.,Lees JA, Zhang Y, Oh MS, Schauder CM, Yu X, Baskin JM, Dobbs K, Notarangelo LD, De Camilli P, Walz T, Reinisch KM Proc Natl Acad Sci U S A. 2017 Dec 11. pii: 1718471115. doi:, 10.1073/pnas.1718471115. PMID:29229838<ref>PMID:29229838</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6bq1" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 18:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: 1-phosphatidylinositol 4-kinase]]		[[Category: 1-phosphatidylinositol 4-kinase]]
		+	[[Category: Human]]
	[[Category: Baskin, J]]		[[Category: Baskin, J]]
	[[Category: Camilli, P D]]		[[Category: Camilli, P D]]

OCA at 07:04, 13 December 2017

OCA — Wed, 13 Dec 2017 07:04:37 GMT

←Older revision		Revision as of 07:04, 13 December 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6bq1 is ~~ON HOLD~~	+	==Human PI4KIIIa lipid kinase complex==
-		+	<StructureSection load='6bq1' size='340' side='right' caption='[[6bq1]], [[Resolution\|resolution]] 3.60Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6bq1]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BQ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BQ1 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=E4S:5-{2-amino-1-[4-(morpholin-4-yl)phenyl]-1H-benzimidazol-6-yl}-N-(2-fluorophenyl)-2-methoxypyridine-3-sulfonamide'>E4S</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1-phosphatidylinositol_4-kinase 1-phosphatidylinositol 4-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.67 2.7.1.67] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bq1 OCA], [http://pdbe.org/6bq1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bq1 RCSB], [http://www.ebi.ac.uk/pdbsum/6bq1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bq1 ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/HYCCI_HUMAN HYCCI_HUMAN]] Hypomyelination - congenital cataract. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HYCCI_HUMAN HYCCI_HUMAN]] May have a role in the beta-catenin/Lef signaling pathway. May have a role in the process of myelination of the central and peripheral nervous system.<ref>PMID:16951682</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: 1-phosphatidylinositol 4-kinase]]
		+	[[Category: Baskin, J]]
		+	[[Category: Camilli, P D]]
		+	[[Category: Dobbs, K]]
		+	[[Category: Lees, J A]]
		+	[[Category: Notarangelo, L D]]
		+	[[Category: Oh, M]]
		+	[[Category: Reinisch, K M]]
		+	[[Category: Schauder, C M]]
		+	[[Category: Walz, T]]
		+	[[Category: Yu, X]]
		+	[[Category: Zhang, Y]]
		+	[[Category: Kinase]]
		+	[[Category: Phosphoinositide synthesis]]
		+	[[Category: Transferase-signaling protein complex]]

OCA: Protected "6bq1" [edit=sysop:move=sysop]

OCA — Wed, 06 Dec 2017 06:05:00 GMT

Protected "6bq1" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:05, 6 December 2017

OCA: New page: '''Unreleased structure''' The entry 6bq1 is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 06 Dec 2017 06:04:58 GMT

New page: '''Unreleased structure''' The entry 6bq1 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6bq1 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]