6bqp - Revision history

OCA at 14:48, 4 October 2023

OCA — Wed, 04 Oct 2023 14:48:35 GMT

←Older revision		Revision as of 14:48, 4 October 2023
Line 3:		Line 3:
	<StructureSection load='6bqp' size='340' side='right'caption='[[6bqp]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='6bqp' size='340' side='right'caption='[[6bqp]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6bqp]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BQP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6BQP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6bqp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BQP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BQP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6T2:1-(2-{5-[(3-Methyloxetan-3-yl)methoxy]-1H-benzimidazol-1-yl}quinolin-8-yl)piperidin-4-amine'>6T2</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.95Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CAMKK2, CAMKKB, KIAA0787 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6T2:1-(2-{5-[(3-Methyloxetan-3-yl)methoxy]-1H-benzimidazol-1-yl}quinolin-8-yl)piperidin-4-amine'>6T2</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium/calmodulin-dependent_protein_kinase Calcium/calmodulin-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.17 2.7.11.17] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bqp OCA], [https://pdbe.org/6bqp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bqp RCSB], [https://www.ebi.ac.uk/pdbsum/6bqp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bqp ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6bqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bqp OCA], [~~http~~://pdbe.org/6bqp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6bqp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6bqp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6bqp ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/KKCC2_HUMAN KKCC2_HUMAN]] Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.<ref>PMID:11395482</ref> <ref>PMID:12935886</ref> <ref>PMID:9662074</ref> <ref>PMID:21957496</ref>	+	[https://www.uniprot.org/uniprot/KKCC2_HUMAN KKCC2_HUMAN] Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.<ref>PMID:11395482</ref> <ref>PMID:12935886</ref> <ref>PMID:9662074</ref> <ref>PMID:21957496</ref>

	==See Also==		==See Also==
Line 18:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Calcium/calmodulin-dependent protein kinase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arruda, P]]	+	[[Category: Arruda P]]
-	[[Category: Counago~~, R M~~]]	+	[[Category: Counago RM]]
-	[[Category: Drewry, D]]	+	[[Category: Drewry D]]
-	[[Category: Edwards~~, A M~~]]	+	[[Category: Edwards AM]]
-	[[Category: Elkins~~, J M~~]]	+	[[Category: Elkins JM]]
-	[[Category: Massirer~~, K B~~]]	+	[[Category: Massirer KB]]
-	[[Category: Ramos~~, P Z]]~~	+	[[Category: Ramos PZ]]
-	~~[[Category: Reis, C V.dos]]~~	+	[[Category: De Souza GP]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Dos Reis CV]]
-	[[Category: Souza~~, G P.de~~]]	+
-	[[Category: ~~Protein kinase domain]]~~	+
-	~~[[Category: Sgc]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Transferase inhibitor complex~~]]	+

OCA at 06:37, 17 April 2019

OCA — Wed, 17 Apr 2019 06:37:30 GMT

←Older revision		Revision as of 06:37, 17 April 2019
Line 1:		Line 1:

	==Crystal Structure of the Human CAMKK2B in complex with Crenolanib==		==Crystal Structure of the Human CAMKK2B in complex with Crenolanib==
-	<StructureSection load='6bqp' size='340' side='right' caption='[[6bqp]], [[Resolution\|resolution]] 1.95Å' scene=''>	+	<StructureSection load='6bqp' size='340' side='right'caption='[[6bqp]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6bqp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BQP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BQP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6bqp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BQP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BQP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6T2:1-(2-{5-[(3-Methyloxetan-3-yl)methoxy]-1H-benzimidazol-1-yl}quinolin-8-yl)piperidin-4-amine'>6T2</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6T2:1-(2-{5-[(3-Methyloxetan-3-yl)methoxy]-1H-benzimidazol-1-yl}quinolin-8-yl)piperidin-4-amine'>6T2</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CAMKK2, CAMKKB, KIAA0787 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium/calmodulin-dependent_protein_kinase Calcium/calmodulin-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.17 2.7.11.17] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium/calmodulin-dependent_protein_kinase Calcium/calmodulin-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.17 2.7.11.17] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bqp OCA], [http://pdbe.org/6bqp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bqp RCSB], [http://www.ebi.ac.uk/pdbsum/6bqp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bqp ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bqp OCA], [http://pdbe.org/6bqp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bqp RCSB], [http://www.ebi.ac.uk/pdbsum/6bqp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bqp ProSAT]</span></td></tr>
Line 10:		Line 11:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/KKCC2_HUMAN KKCC2_HUMAN]] Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.<ref>PMID:11395482</ref> <ref>PMID:12935886</ref> <ref>PMID:9662074</ref> <ref>PMID:21957496</ref>		[[http://www.uniprot.org/uniprot/KKCC2_HUMAN KKCC2_HUMAN]] Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.<ref>PMID:11395482</ref> <ref>PMID:12935886</ref> <ref>PMID:9662074</ref> <ref>PMID:21957496</ref>
		+
		+	==See Also==
		+	*[[Calcium/calmodulin-dependent protein kinase kinase\|Calcium/calmodulin-dependent protein kinase kinase]]
	== References ==		== References ==
	<references/>		<references/>
Line 15:		Line 19:
	</StructureSection>		</StructureSection>
	[[Category: Calcium/calmodulin-dependent protein kinase]]		[[Category: Calcium/calmodulin-dependent protein kinase]]
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Arruda, P]]		[[Category: Arruda, P]]
	[[Category: Counago, R M]]		[[Category: Counago, R M]]

OCA at 07:04, 13 December 2017

OCA — Wed, 13 Dec 2017 07:04:27 GMT

←Older revision		Revision as of 07:04, 13 December 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6bqp ~~is ON HOLD~~	+	==Crystal Structure of the Human CAMKK2B in complex with Crenolanib==
-		+	<StructureSection load='6bqp' size='340' side='right' caption='[[6bqp]], [[Resolution\|resolution]] 1.95Å' scene=''>
-	~~Authors~~: ~~Counago, R~~.M., ~~de Souza~~, G.P., ~~dos Reis, C~~.V., ~~Ramos, P~~.Z., ~~Drewry, D~~., ~~Massirer~~, K.B.~~, Arruda, P~~., ~~Edwards~~, A.M., ~~Elkins~~, J.M.~~, Structural Genomics Consortium~~ (~~SGC~~)	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6bqp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BQP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BQP FirstGlance]. <br>
-	~~Description~~: ~~Crystal Structure of the Human CAMKK2B in complex with Crenolanib~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6T2:1-(2-{5-[(3-Methyloxetan-3-yl)methoxy]-1H-benzimidazol-1-yl}quinolin-8-yl)piperidin-4-amine'>6T2</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium/calmodulin-dependent_protein_kinase Calcium/calmodulin-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.17 2.7.11.17] </span></td></tr>
-	[[Category: ~~Elkins~~, J.M]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bqp OCA], [http://pdbe.org/6bqp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bqp RCSB], [http://www.ebi.ac.uk/pdbsum/6bqp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bqp ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KKCC2_HUMAN KKCC2_HUMAN]] Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.<ref>PMID:11395482</ref> <ref>PMID:12935886</ref> <ref>PMID:9662074</ref> <ref>PMID:21957496</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Calcium/calmodulin-dependent protein kinase]]
		+	[[Category: Arruda, P]]
		+	[[Category: Counago, R M]]
	[[Category: Drewry, D]]		[[Category: Drewry, D]]
-	[[Category: Edwards, A.M]]	+	[[Category: Edwards, A M]]
-	[[Category: ~~Arruda~~, ~~P]]~~	+	[[Category: Elkins, J M]]
-	~~[[Category: Structural Genomics Consortium (Sgc)~~]]	+	[[Category: Massirer, K B]]
-	[[Category: Massirer, K.B]]	+	[[Category: Ramos, P Z]]
-	[[Category: Ramos, P.Z]]	+	[[Category: Reis, C V.dos]]
-	[[Category: ~~Counago~~, R.M]]	+	[[Category: Structural genomic]]
-	[[Category: ~~Dos Reis, C.V~~]]	+	[[Category: Souza, G P.de]]
-	[[Category: De Souza, G.P]]	+	[[Category: Protein kinase domain]]
		+	[[Category: Sgc]]
		+	[[Category: Transferase]]
		+	[[Category: Transferase inhibitor complex]]

OCA: Protected "6bqp" [edit=sysop:move=sysop]

OCA — Wed, 06 Dec 2017 06:06:24 GMT

Protected "6bqp" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:06, 6 December 2017

OCA: New page: '''Unreleased structure''' The entry 6bqp is ON HOLD Authors: Counago, R.M., de Souza, G.P., dos Reis, C.V., Ramos, P.Z., Drewry, D., Massirer, K.B., Arruda, P., Edwards, A.M., Elkins, ...

OCA — Wed, 06 Dec 2017 06:06:23 GMT

New page: '''Unreleased structure''' The entry 6bqp is ON HOLD Authors: Counago, R.M., de Souza, G.P., dos Reis, C.V., Ramos, P.Z., Drewry, D., Massirer, K.B., Arruda, P., Edwards, A.M., Elkins, ...

New page

'''Unreleased structure'''

The entry 6bqp is ON HOLD

Authors: Counago, R.M., de Souza, G.P., dos Reis, C.V., Ramos, P.Z., Drewry, D., Massirer, K.B., Arruda, P., Edwards, A.M., Elkins, J.M., Structural Genomics Consortium (SGC)

Description: Crystal Structure of the Human CAMKK2B in complex with Crenolanib
[[Category: Unreleased Structures]]
[[Category: Elkins, J.M]]
[[Category: Drewry, D]]
[[Category: Edwards, A.M]]
[[Category: Arruda, P]]
[[Category: Structural Genomics Consortium (Sgc)]]
[[Category: Massirer, K.B]]
[[Category: Ramos, P.Z]]
[[Category: Counago, R.M]]
[[Category: Dos Reis, C.V]]
[[Category: De Souza, G.P]]