6bsr - Revision history

OCA at 14:24, 13 March 2024

OCA — Wed, 13 Mar 2024 14:24:22 GMT

←Older revision		Revision as of 14:24, 13 March 2024
Line 3:		Line 3:
	<StructureSection load='6bsr' size='340' side='right'caption='[[6bsr]], [[Resolution\|resolution]] 2.34Å' scene=''>		<StructureSection load='6bsr' size='340' side='right'caption='[[6bsr]], [[Resolution\|resolution]] 2.34Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6bsr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"enterococcus_proteiformis"_thiercelin_and_jouhaud_1903 "enterococcus proteiformis" thiercelin and jouhaud 1903~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BSR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BSR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6bsr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BSR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BSR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PNM:OPEN+FORM+-+PENICILLIN+G'>PNM</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.34Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6bsq\|6bsq]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PNM:OPEN+FORM+-+PENICILLIN+G'>PNM</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pbp4, DRJ71_03440, FKY84_09230, KUB3007_C20250 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1351 "Enterococcus proteiformis" Thiercelin and Jouhaud 1903]), pbp4, A6B47_10405 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1351 "Enterococcus proteiformis" Thiercelin and Jouhaud 1903])</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bsr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bsr OCA], [https://pdbe.org/6bsr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bsr RCSB], [https://www.ebi.ac.uk/pdbsum/6bsr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bsr ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bsr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bsr OCA], [https://pdbe.org/6bsr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bsr RCSB], [https://www.ebi.ac.uk/pdbsum/6bsr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bsr ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/Q9K3C9_ENTFL Q9K3C9_ENTFL]
-	The final steps of cell-wall biosynthesis in bacteria are carried out by penicillin-binding proteins (PBPs), whose transpeptidase domains form the crosslinks in peptidoglycan chains that define the bacterial cell wall. These enzymes are the targets of beta-lactam antibiotics, as their inhibition reduces the structural integrity of the cell wall. Bacterial resistance to antibiotics is a rapidly growing concern; however, the structural underpinnings of PBP-derived antibiotic resistance are poorly understood. PBP4 and PBP5 are low-affinity, class B transpeptidases that confer antibiotic resistance to Enterococcus faecalis and Enterococcus faecium, respectively. Here, we report the crystal structures of PBP4 (1.8 A) and PBP5 (2.7 A) in their apo and acyl-enzyme complexes with the beta-lactams benzylpenicillin, imipenem and ceftaroline. We found that, although these three beta-lactams adopt geometries similar to those observed in other class B PBP structures, there are small, but significant differences that likely decrease antibiotic efficacy. Further, we also discovered that the N-terminal domain extensions in this class of PBPs undergo large rigid-body rotations without impacting the structure of the catalytic transpeptidase domain. Together, our findings are defining the subtle functional and structural differences in the enterococcus PBPs that allow them to support transpeptidase activity while also conferring bacterial resistance to antibiotics that function as substrate mimics.	+
-		+
-	The structures of penicillin binding protein 4 (PBP4) and PBP5 from Enterococci provide structural insights into beta-lactam resistance.,Moon TM, D'Andrea ED, Lee CW, Soares A, Jakoncic J, Desbonnet C, Solache MG, Rice LB, Page R, Peti W J Biol Chem. 2018 Oct 24. pii: ~~RA118.006052. doi: 10.1074~~/~~jbc.RA118.006052. PMID:30355734<ref>PMID:30355734<~~/~~ref>~~	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~	+
-	</~~div>~~	+
-	~~<div class="pdbe-citations 6bsr" style="background-color:#fffaf0;"><~~/~~div>~~	+

	==See Also==		==See Also==
	*[[Penicillin-binding protein 3D structures\|Penicillin-binding protein 3D structures]]		*[[Penicillin-binding protein 3D structures\|Penicillin-binding protein 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Enterococcus ~~proteiformis thiercelin and jouhaud 1903~~]]	+	[[Category: Enterococcus faecalis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Andrea~~, E D.D~~]]	+	[[Category: D'Andrea ED]]
-	[[Category: Moon~~, T M~~]]	+	[[Category: Moon TM]]
-	[[Category: Page, R]]	+	[[Category: Page R]]
-	[[Category: Peti, W]]	+	[[Category: Peti W]]
-	~~[[Category: Antibiotic]]~~	+
-	~~[[Category: Benzylpenicillin]]~~	+
-	~~[[Category: Beta-lactam]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Penicillin binding protein]]~~	+
-	~~[[Category: Transpeptidase~~]]	+

OCA at 15:52, 3 November 2021

OCA — Wed, 03 Nov 2021 15:52:23 GMT

←Older revision		Revision as of 15:52, 3 November 2021
Line 3:		Line 3:
	<StructureSection load='6bsr' size='340' side='right'caption='[[6bsr]], [[Resolution\|resolution]] 2.34Å' scene=''>		<StructureSection load='6bsr' size='340' side='right'caption='[[6bsr]], [[Resolution\|resolution]] 2.34Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6bsr]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"enterococcus_proteiformis"_thiercelin_and_jouhaud_1903 "enterococcus proteiformis" thiercelin and jouhaud 1903]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BSR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6BSR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6bsr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"enterococcus_proteiformis"_thiercelin_and_jouhaud_1903 "enterococcus proteiformis" thiercelin and jouhaud 1903]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BSR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BSR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PNM:OPEN+FORM+-+PENICILLIN+G'>PNM</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=~~PG1~~:PENICILLIN+G~~+ACYL-SERINE~~'>~~PG1~~</scene></td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6bsq\|6bsq]]</div></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6bsq\|6bsq]]</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pbp4, DRJ71_03440, FKY84_09230, KUB3007_C20250 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1351 "Enterococcus proteiformis" Thiercelin and Jouhaud 1903]), pbp4, A6B47_10405 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1351 "Enterococcus proteiformis" Thiercelin and Jouhaud 1903])</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pbp4, A6B47_10405 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1351 "Enterococcus proteiformis" Thiercelin and Jouhaud 1903])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bsr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bsr OCA], [https://pdbe.org/6bsr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bsr RCSB], [https://www.ebi.ac.uk/pdbsum/6bsr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bsr ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6bsr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bsr OCA], [~~http~~://pdbe.org/6bsr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6bsr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6bsr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6bsr ProSAT]</span></td></tr>	+
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 17:50, 11 December 2019

OCA — Wed, 11 Dec 2019 17:50:59 GMT

←Older revision		Revision as of 17:50, 11 December 2019
Line 1:		Line 1:

	==Crystal structure of penicillin-binding protein 4 (PBP4) from Enterococcus faecalis in the benzylpenicillin bound form.==		==Crystal structure of penicillin-binding protein 4 (PBP4) from Enterococcus faecalis in the benzylpenicillin bound form.==
-	<StructureSection load='6bsr' size='340' side='right' caption='[[6bsr]], [[Resolution\|resolution]] 2.34Å' scene=''>	+	<StructureSection load='6bsr' size='340' side='right'caption='[[6bsr]], [[Resolution\|resolution]] 2.34Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6bsr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"enterococcus_proteiformis"_thiercelin_and_jouhaud_1903 "enterococcus proteiformis" thiercelin and jouhaud 1903]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BSR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BSR FirstGlance]. <br>		<table><tr><td colspan='2'>[[6bsr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"enterococcus_proteiformis"_thiercelin_and_jouhaud_1903 "enterococcus proteiformis" thiercelin and jouhaud 1903]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BSR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BSR FirstGlance]. <br>
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 6bsr" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6bsr" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Penicillin-binding protein 3D structures\|Penicillin-binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 24:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Enterococcus proteiformis thiercelin and jouhaud 1903]]		[[Category: Enterococcus proteiformis thiercelin and jouhaud 1903]]
		+	[[Category: Large Structures]]
	[[Category: Andrea, E D.D]]		[[Category: Andrea, E D.D]]
	[[Category: Moon, T M]]		[[Category: Moon, T M]]

OCA at 12:40, 7 November 2018

OCA — Wed, 07 Nov 2018 12:40:22 GMT

←Older revision		Revision as of 12:40, 7 November 2018
Line 3:		Line 3:
	<StructureSection load='6bsr' size='340' side='right' caption='[[6bsr]], [[Resolution\|resolution]] 2.34Å' scene=''>		<StructureSection load='6bsr' size='340' side='right' caption='[[6bsr]], [[Resolution\|resolution]] 2.34Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6bsr]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BSR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BSR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6bsr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"enterococcus_proteiformis"_thiercelin_and_jouhaud_1903 "enterococcus proteiformis" thiercelin and jouhaud 1903]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BSR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BSR FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PG1:PENICILLIN+G+ACYL-SERINE'>PG1</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PG1:PENICILLIN+G+ACYL-SERINE'>PG1</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6bsq\|6bsq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6bsq\|6bsq]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pbp4, A6B47_10405 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1351 "Enterococcus proteiformis" Thiercelin and Jouhaud 1903])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bsr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bsr OCA], [http://pdbe.org/6bsr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bsr RCSB], [http://www.ebi.ac.uk/pdbsum/6bsr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bsr ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bsr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bsr OCA], [http://pdbe.org/6bsr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bsr RCSB], [http://www.ebi.ac.uk/pdbsum/6bsr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bsr ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The final steps of cell-wall biosynthesis in bacteria are carried out by penicillin-binding proteins (PBPs), whose transpeptidase domains form the crosslinks in peptidoglycan chains that define the bacterial cell wall. These enzymes are the targets of beta-lactam antibiotics, as their inhibition reduces the structural integrity of the cell wall. Bacterial resistance to antibiotics is a rapidly growing concern; however, the structural underpinnings of PBP-derived antibiotic resistance are poorly understood. PBP4 and PBP5 are low-affinity, class B transpeptidases that confer antibiotic resistance to Enterococcus faecalis and Enterococcus faecium, respectively. Here, we report the crystal structures of PBP4 (1.8 A) and PBP5 (2.7 A) in their apo and acyl-enzyme complexes with the beta-lactams benzylpenicillin, imipenem and ceftaroline. We found that, although these three beta-lactams adopt geometries similar to those observed in other class B PBP structures, there are small, but significant differences that likely decrease antibiotic efficacy. Further, we also discovered that the N-terminal domain extensions in this class of PBPs undergo large rigid-body rotations without impacting the structure of the catalytic transpeptidase domain. Together, our findings are defining the subtle functional and structural differences in the enterococcus PBPs that allow them to support transpeptidase activity while also conferring bacterial resistance to antibiotics that function as substrate mimics.
		+
		+	The structures of penicillin binding protein 4 (PBP4) and PBP5 from Enterococci provide structural insights into beta-lactam resistance.,Moon TM, D'Andrea ED, Lee CW, Soares A, Jakoncic J, Desbonnet C, Solache MG, Rice LB, Page R, Peti W J Biol Chem. 2018 Oct 24. pii: RA118.006052. doi: 10.1074/jbc.RA118.006052. PMID:30355734<ref>PMID:30355734</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6bsr" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Enterococcus proteiformis thiercelin and jouhaud 1903]]
	[[Category: Andrea, E D.D]]		[[Category: Andrea, E D.D]]
	[[Category: Moon, T M]]		[[Category: Moon, T M]]

OCA at 06:48, 31 October 2018

OCA — Wed, 31 Oct 2018 06:48:46 GMT

←Older revision		Revision as of 06:48, 31 October 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 6bsr is ON HOLD until Paper Publication~~	+	==Crystal structure of penicillin-binding protein 4 (PBP4) from Enterococcus faecalis in the benzylpenicillin bound form.==
-		+	<StructureSection load='6bsr' size='340' side='right' caption='[[6bsr]], [[Resolution\|resolution]] 2.34Å' scene=''>
-	~~Authors: Moon, T.M., D'Andrea, E.D., Peti, W., Page, R.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6bsr]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BSR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BSR FirstGlance]. <br>
-	~~Description:~~ Crystal structure of penicillin-binding protein 4 (PBP4) from Enterococcus faecalis in the benzylpenicillin bound form.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PG1:PENICILLIN+G+ACYL-SERINE'>PG1</scene></td></tr>
-	[[~~Category~~: D'Andrea, E.D]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6bsq\|6bsq]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bsr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bsr OCA], [http://pdbe.org/6bsr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bsr RCSB], [http://www.ebi.ac.uk/pdbsum/6bsr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bsr ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Andrea, E D.D]]
		+	[[Category: Moon, T M]]
	[[Category: Page, R]]		[[Category: Page, R]]
	[[Category: Peti, W]]		[[Category: Peti, W]]
-	[[Category: ~~Moon, T.M~~]]	+	[[Category: Antibiotic]]
		+	[[Category: Benzylpenicillin]]
		+	[[Category: Beta-lactam]]
		+	[[Category: Hydrolase]]
		+	[[Category: Penicillin binding protein]]
		+	[[Category: Transpeptidase]]

OCA at 03:41, 8 March 2018

OCA — Thu, 08 Mar 2018 03:41:37 GMT

←Older revision		Revision as of 03:41, 8 March 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6bsr is ON HOLD	+	The entry 6bsr is ON HOLD until Paper Publication

	Authors: Moon, T.M., D'Andrea, E.D., Peti, W., Page, R.		Authors: Moon, T.M., D'Andrea, E.D., Peti, W., Page, R.
Line 8:		Line 8:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: D'Andrea, E.D]]		[[Category: D'Andrea, E.D]]
-	[[Category: Peti, W]]
	[[Category: Page, R]]		[[Category: Page, R]]
		+	[[Category: Peti, W]]
	[[Category: Moon, T.M]]		[[Category: Moon, T.M]]

OCA: Protected "6bsr" [edit=sysop:move=sysop]

OCA — Wed, 13 Dec 2017 05:54:34 GMT

Protected "6bsr" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:54, 13 December 2017

OCA: New page: '''Unreleased structure''' The entry 6bsr is ON HOLD Authors: Moon, T.M., D'Andrea, E.D., Peti, W., Page, R. Description: Crystal structure of penicillin-binding protein 4 (PBP4) from ...

OCA — Wed, 13 Dec 2017 05:54:33 GMT

New page: '''Unreleased structure''' The entry 6bsr is ON HOLD Authors: Moon, T.M., D'Andrea, E.D., Peti, W., Page, R. Description: Crystal structure of penicillin-binding protein 4 (PBP4) from ...

New page

'''Unreleased structure'''

The entry 6bsr is ON HOLD

Authors: Moon, T.M., D'Andrea, E.D., Peti, W., Page, R.

Description: Crystal structure of penicillin-binding protein 4 (PBP4) from Enterococcus faecalis in the benzylpenicillin bound form.
[[Category: Unreleased Structures]]
[[Category: D'Andrea, E.D]]
[[Category: Peti, W]]
[[Category: Page, R]]
[[Category: Moon, T.M]]