6bti - Revision history

OCA at 14:50, 4 October 2023

OCA — Wed, 04 Oct 2023 14:50:01 GMT

←Older revision		Revision as of 14:50, 4 October 2023
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	<StructureSection load='6bti' size='340' side='right'caption='[[6bti]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='6bti' size='340' side='right'caption='[[6bti]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6bti]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BTI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6BTI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6bti]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BTI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BTI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E7Y:(5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide'>E7Y</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.45Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RBP2, CRBP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E7Y:(5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide'>E7Y</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6bti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bti OCA], [~~http~~://pdbe.org/6bti PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6bti RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6bti PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6bti ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bti OCA], [https://pdbe.org/6bti PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bti RCSB], [https://www.ebi.ac.uk/pdbsum/6bti PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bti ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/RET2_HUMAN RET2_HUMAN]] Intracellular transport of retinol.	+	[https://www.uniprot.org/uniprot/RET2_HUMAN RET2_HUMAN] Intracellular transport of retinol.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Blaner~~, W S~~]]	+	[[Category: Blaner WS]]
-	[[Category: Golczak, M]]	+	[[Category: Golczak M]]
-	[[Category: Lodowski~~, D T~~]]	+	[[Category: Lodowski DT]]
-	[[Category: Silvaroli~~, J A]]~~	+	[[Category: Silvaroli JA]]
-	~~[[Category: Anandamide]]~~	+
-	~~[[Category: Endocannabinoid]]~~	+
-	~~[[Category: Lipid binding protein]]~~	+
-	~~[[Category: N-arachidonoylethanolamine]]~~	+
-	~~[[Category: Retinol]]~~	+
-	~~[[Category: Vitamin some~~]]	+

OCA at 05:55, 20 May 2020

OCA — Wed, 20 May 2020 05:55:42 GMT

←Older revision		Revision as of 05:55, 20 May 2020
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	<StructureSection load='6bti' size='340' side='right'caption='[[6bti]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='6bti' size='340' side='right'caption='[[6bti]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6bti]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BTI OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6BTI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6bti]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BTI OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6BTI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=E7Y:(5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide'>E7Y</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E7Y:(5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide'>E7Y</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RBP2, CRBP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RBP2, CRBP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6bti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bti OCA], [http://pdbe.org/6bti PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bti RCSB], [http://www.ebi.ac.uk/pdbsum/6bti PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bti ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6bti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bti OCA], [http://pdbe.org/6bti PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bti RCSB], [http://www.ebi.ac.uk/pdbsum/6bti PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bti ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/RET2_HUMAN RET2_HUMAN]] Intracellular transport of retinol.		[[http://www.uniprot.org/uniprot/RET2_HUMAN RET2_HUMAN]] Intracellular transport of retinol.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Expressed in the small intestine, retinol-binding protein 2 (RBP2) facilitates dietary retinoid absorption. Rbp2-deficient (Rbp2(-/-) ) mice fed a chow diet exhibit by 6-7 months-of-age higher body weights, impaired glucose metabolism, and greater hepatic triglyceride levels compared to controls. These phenotypes are also observed when young Rbp2(-/-) mice are fed a high fat diet. Retinoids do not account for the phenotypes. Rather, RBP2 is a previously unidentified monoacylglycerol (MAG)-binding protein, interacting with the endocannabinoid 2-arachidonoylglycerol (2-AG) and other MAGs with affinities comparable to retinol. X-ray crystallographic studies show that MAGs bind in the retinol binding pocket. When challenged with an oil gavage, Rbp2(-/-) mice show elevated mucosal levels of 2-MAGs. This is accompanied by significantly elevated blood levels of the gut hormone GIP (glucose-dependent insulinotropic polypeptide). Thus, RBP2, in addition to facilitating dietary retinoid absorption, modulates MAG metabolism and likely signaling, playing a heretofore unknown role in systemic energy balance.
		+
		+	Retinol-binding protein 2 (RBP2) binds monoacylglycerols and modulates gut endocrine signaling and body weight.,Lee SA, Yang KJZ, Brun PJ, Silvaroli JA, Yuen JJ, Shmarakov I, Jiang H, Feranil JB, Li X, Lackey AI, Krezel W, Leibel RL, Libien J, Storch J, Golczak M, Blaner WS Sci Adv. 2020 Mar 11;6(11):eaay8937. doi: 10.1126/sciadv.aay8937. eCollection, 2020 Mar. PMID:32195347<ref>PMID:32195347</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6bti" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Retinol-binding protein 3D structures\|Retinol-binding protein 3D structures]]		*[[Retinol-binding protein 3D structures\|Retinol-binding protein 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 09:23, 18 December 2019

OCA — Wed, 18 Dec 2019 09:23:11 GMT

←Older revision		Revision as of 09:23, 18 December 2019
Line 1:		Line 1:

	==Crystal structure of human cellular retinol binding protein 2 (CRBP2) in complex with N-arachidonoylethanolamine (AEA)==		==Crystal structure of human cellular retinol binding protein 2 (CRBP2) in complex with N-arachidonoylethanolamine (AEA)==
-	<StructureSection load='6bti' size='340' side='right' caption='[[6bti]], [[Resolution\|resolution]] 1.45Å' scene=''>	+	<StructureSection load='6bti' size='340' side='right'caption='[[6bti]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6bti]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BTI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BTI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6bti]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BTI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BTI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=E7Y:(5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide'>E7Y</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=E7Y:(5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide'>E7Y</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RBP2, CRBP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bti OCA], [http://pdbe.org/6bti PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bti RCSB], [http://www.ebi.ac.uk/pdbsum/6bti PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bti ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bti OCA], [http://pdbe.org/6bti PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bti RCSB], [http://www.ebi.ac.uk/pdbsum/6bti PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bti ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/RET2_HUMAN RET2_HUMAN]] Intracellular transport of retinol.		[[http://www.uniprot.org/uniprot/RET2_HUMAN RET2_HUMAN]] Intracellular transport of retinol.
		+
		+	==See Also==
		+	*[[Retinol-binding protein 3D structures\|Retinol-binding protein 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Blaner, W S]]		[[Category: Blaner, W S]]
	[[Category: Golczak, M]]		[[Category: Golczak, M]]

OCA at 06:42, 12 December 2018

OCA — Wed, 12 Dec 2018 06:42:19 GMT

←Older revision		Revision as of 06:42, 12 December 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6bti is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of human cellular retinol binding protein 2 (CRBP2) in complex with N-arachidonoylethanolamine (AEA)==
-		+	<StructureSection load='6bti' size='340' side='right' caption='[[6bti]], [[Resolution\|resolution]] 1.45Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6bti]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BTI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BTI FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=E7Y:(5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide'>E7Y</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bti OCA], [http://pdbe.org/6bti PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bti RCSB], [http://www.ebi.ac.uk/pdbsum/6bti PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bti ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RET2_HUMAN RET2_HUMAN]] Intracellular transport of retinol.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Blaner, W S]]
		+	[[Category: Golczak, M]]
		+	[[Category: Lodowski, D T]]
		+	[[Category: Silvaroli, J A]]
		+	[[Category: Anandamide]]
		+	[[Category: Endocannabinoid]]
		+	[[Category: Lipid binding protein]]
		+	[[Category: N-arachidonoylethanolamine]]
		+	[[Category: Retinol]]
		+	[[Category: Vitamin some]]

OCA at 05:00, 20 December 2017

OCA — Wed, 20 Dec 2017 05:00:48 GMT

←Older revision		Revision as of 05:00, 20 December 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6bti is ON HOLD	+	The entry 6bti is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6bti" [edit=sysop:move=sysop]

OCA — Wed, 13 Dec 2017 05:57:01 GMT

Protected "6bti" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:57, 13 December 2017

OCA: New page: '''Unreleased structure''' The entry 6bti is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 13 Dec 2017 05:57:00 GMT

New page: '''Unreleased structure''' The entry 6bti is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6bti is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]