6bx7 - Revision history

OCA at 14:52, 4 October 2023

OCA — Wed, 04 Oct 2023 14:52:03 GMT

←Older revision		Revision as of 14:52, 4 October 2023
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	<StructureSection load='6bx7' size='340' side='right'caption='[[6bx7]], [[Resolution\|resolution]] 2.85Å' scene=''>		<StructureSection load='6bx7' size='340' side='right'caption='[[6bx7]], [[Resolution\|resolution]] 2.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6bx7]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BX7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6BX7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6bx7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BX7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BX7 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=CA:CALCIUM+ION'>CA</scene~~>, ~~<scene name='pdbligand=EPE:4-(~~2~~-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.85Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~PCDH1 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN]~~)</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6bx7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bx7 OCA], [~~http~~://pdbe.org/6bx7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6bx7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6bx7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6bx7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bx7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bx7 OCA], [https://pdbe.org/6bx7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bx7 RCSB], [https://www.ebi.ac.uk/pdbsum/6bx7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bx7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PCDH1_HUMAN PCDH1_HUMAN]] May be involved in cell-cell interaction processes and in cell adhesion.	+	[https://www.uniprot.org/uniprot/PCDH1_HUMAN PCDH1_HUMAN] May be involved in cell-cell interaction processes and in cell adhesion.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Modak, D]]	+	[[Category: Modak D]]
-	[[Category: Sotomayor, M]]	+	[[Category: Sotomayor M]]
-	~~[[Category: Adhesion]]~~	+
-	~~[[Category: Asthma]]~~	+
-	~~[[Category: Cadherin]]~~	+
-	~~[[Category: Calcium-binding protein]]~~	+
-	~~[[Category: Cell adhesion~~]]	+

OCA at 07:03, 16 October 2019

OCA — Wed, 16 Oct 2019 07:03:19 GMT

←Older revision		Revision as of 07:03, 16 October 2019
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	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/PCDH1_HUMAN PCDH1_HUMAN]] May be involved in cell-cell interaction processes and in cell adhesion.		[[http://www.uniprot.org/uniprot/PCDH1_HUMAN PCDH1_HUMAN]] May be involved in cell-cell interaction processes and in cell adhesion.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cadherins form a large family of calcium-dependent adhesive proteins involved in morphogenesis, cell differentiation, and neuronal connectivity. Non-clustered delta1 protocadherins form a cadherin subgroup of proteins with seven extracellular cadherin (EC) repeats and cytoplasmic domains distinct from those of classical cadherins. Non-clustered delta1 protocadherins mediate homophilic adhesion and have been implicated in various diseases including asthma, autism, and cancer. Here we present X-ray crystal structures of human Protocadherin-1 (PCDH1), a delta1-protocadherin member essential for New World Hantavirus infection that is typically expressed in the brain, airway epithelium, skin keratinocytes, and lungs. The structures suggest a binding mode that involves antiparallel overlap of repeats EC1 to EC4. Mutagenesis combined with binding assays and biochemical experiments validated this mode of adhesion. Overall, these results reveal the molecular mechanism underlying adhesiveness of PCDH1 and delta1-protocadherins, also shedding light on PCDH1's role in maintaining airway epithelial integrity, the loss of which causes respiratory diseases.
		+
		+	Identification of an adhesive interface for the non-clustered delta1 protocadherin-1 involved in respiratory diseases.,Modak D, Sotomayor M Commun Biol. 2019 Sep 30;2:354. doi: 10.1038/s42003-019-0586-0. eCollection 2019. PMID:31583286<ref>PMID:31583286</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6bx7" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Cadherin 3D structures\|Cadherin 3D structures]]		*[[Cadherin 3D structures\|Cadherin 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 05:59, 10 October 2019

OCA — Thu, 10 Oct 2019 05:59:30 GMT

←Older revision		Revision as of 05:59, 10 October 2019
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	==Crystal Structure of Human Protocadherin-1 EC1-4==		==Crystal Structure of Human Protocadherin-1 EC1-4==
-	<StructureSection load='6bx7' size='340' side='right' caption='[[6bx7]], [[Resolution\|resolution]] 2.85Å' scene=''>	+	<StructureSection load='6bx7' size='340' side='right'caption='[[6bx7]], [[Resolution\|resolution]] 2.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6bx7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BX7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BX7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6bx7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BX7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BX7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PCDH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bx7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bx7 OCA], [http://pdbe.org/6bx7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bx7 RCSB], [http://www.ebi.ac.uk/pdbsum/6bx7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bx7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bx7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bx7 OCA], [http://pdbe.org/6bx7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bx7 RCSB], [http://www.ebi.ac.uk/pdbsum/6bx7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bx7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/PCDH1_HUMAN PCDH1_HUMAN]] May be involved in cell-cell interaction processes and in cell adhesion.		[[http://www.uniprot.org/uniprot/PCDH1_HUMAN PCDH1_HUMAN]] May be involved in cell-cell interaction processes and in cell adhesion.
		+
		+	==See Also==
		+	*[[Cadherin 3D structures\|Cadherin 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Modak, D]]		[[Category: Modak, D]]
	[[Category: Sotomayor, M]]		[[Category: Sotomayor, M]]

OCA at 08:17, 19 December 2018

OCA — Wed, 19 Dec 2018 08:17:34 GMT

←Older revision		Revision as of 08:17, 19 December 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6bx7 is ~~ON HOLD until Paper Publication~~	+	==Crystal Structure of Human Protocadherin-1 EC1-4==
-		+	<StructureSection load='6bx7' size='340' side='right' caption='[[6bx7]], [[Resolution\|resolution]] 2.85Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6bx7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BX7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BX7 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bx7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bx7 OCA], [http://pdbe.org/6bx7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bx7 RCSB], [http://www.ebi.ac.uk/pdbsum/6bx7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bx7 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PCDH1_HUMAN PCDH1_HUMAN]] May be involved in cell-cell interaction processes and in cell adhesion.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Modak, D]]
		+	[[Category: Sotomayor, M]]
		+	[[Category: Adhesion]]
		+	[[Category: Asthma]]
		+	[[Category: Cadherin]]
		+	[[Category: Calcium-binding protein]]
		+	[[Category: Cell adhesion]]

OCA at 05:40, 17 January 2018

OCA — Wed, 17 Jan 2018 05:40:26 GMT

←Older revision		Revision as of 05:40, 17 January 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6bx7 is ON HOLD	+	The entry 6bx7 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 07:11, 10 January 2018

OCA — Wed, 10 Jan 2018 07:11:13 GMT

←Older revision		Revision as of 07:11, 10 January 2018
Line 3:		Line 3:
	The entry 6bx7 is ON HOLD		The entry 6bx7 is ON HOLD

-	Authors: ~~Modak, D., Sotomayor, M.~~	+	Authors:

-	Description: ~~Crystal Structure of Human Protocadherin-1 EC1-4~~	+	Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Sotomayor, M]]
-	[[Category: Modak, D]]

OCA: Protected "6bx7" [edit=sysop:move=sysop]

OCA — Wed, 27 Dec 2017 07:20:21 GMT

Protected "6bx7" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:20, 27 December 2017

OCA: New page: '''Unreleased structure''' The entry 6bx7 is ON HOLD Authors: Modak, D., Sotomayor, M. Description: Crystal Structure of Human Protocadherin-1 EC1-4 Category: Unreleased Structures...

OCA — Wed, 27 Dec 2017 07:20:19 GMT

New page: '''Unreleased structure''' The entry 6bx7 is ON HOLD Authors: Modak, D., Sotomayor, M. Description: Crystal Structure of Human Protocadherin-1 EC1-4 Category: Unreleased Structures...

New page

'''Unreleased structure'''

The entry 6bx7 is ON HOLD

Authors: Modak, D., Sotomayor, M.

Description: Crystal Structure of Human Protocadherin-1 EC1-4
[[Category: Unreleased Structures]]
[[Category: Sotomayor, M]]
[[Category: Modak, D]]