6bxe - Revision history

OCA at 14:52, 4 October 2023

OCA — Wed, 04 Oct 2023 14:52:10 GMT

←Older revision		Revision as of 14:52, 4 October 2023
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	<StructureSection load='6bxe' size='340' side='right'caption='[[6bxe]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='6bxe' size='340' side='right'caption='[[6bxe]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6bxe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Petma Petma~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BXE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BXE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6bxe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Petromyzon_marinus Petromyzon marinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BXE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BXE FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bxe OCA], [https://pdbe.org/6bxe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bxe RCSB], [https://www.ebi.ac.uk/pdbsum/6bxe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bxe ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.651Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bxe OCA], [https://pdbe.org/6bxe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bxe RCSB], [https://www.ebi.ac.uk/pdbsum/6bxe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bxe ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A5HBR7_PETMA A5HBR7_PETMA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Petma~~]]	+	[[Category: Petromyzon marinus]]
-	[[Category: Cooper~~, M D~~]]	+	[[Category: Cooper MD]]
-	[[Category: Gunn~~, R J~~]]	+	[[Category: Gunn RJ]]
-	[[Category: Herrin~~, B R~~]]	+	[[Category: Herrin BR]]
-	[[Category: Wilson~~, I A]]~~	+	[[Category: Wilson IA]]
-	~~[[Category: Immune receptor]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Lamprey antibody]]~~	+
-	~~[[Category: Leucine-rich repeat]]~~	+
-	~~[[Category: Vlr~~]]	+

OCA at 11:40, 23 March 2022

OCA — Wed, 23 Mar 2022 11:40:20 GMT

←Older revision		Revision as of 11:40, 23 March 2022
Line 3:		Line 3:
	<StructureSection load='6bxe' size='340' side='right'caption='[[6bxe]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='6bxe' size='340' side='right'caption='[[6bxe]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6bxe]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Petma Petma]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BXE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6BXE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6bxe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Petma Petma]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BXE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BXE FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6bxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bxe OCA], [~~http~~://pdbe.org/6bxe PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6bxe RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6bxe PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6bxe ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bxe OCA], [https://pdbe.org/6bxe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bxe RCSB], [https://www.ebi.ac.uk/pdbsum/6bxe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bxe ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	==See Also==		==See Also==
-	*[[Variable lymphocyte receptor\|Variable lymphocyte receptor]]	+	*[[Variable lymphocyte receptor 3D structures\|Variable lymphocyte receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:25, 18 December 2019

OCA — Wed, 18 Dec 2019 09:25:39 GMT

←Older revision		Revision as of 09:25, 18 December 2019
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	==Crystal structure of Variable Lymphocyte Receptor 9 (VLR9)==		==Crystal structure of Variable Lymphocyte Receptor 9 (VLR9)==
-	<StructureSection load='6bxe' size='340' side='right' caption='[[6bxe]], [[Resolution\|resolution]] 1.65Å' scene=''>	+	<StructureSection load='6bxe' size='340' side='right'caption='[[6bxe]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6bxe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Petma Petma]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BXE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BXE FirstGlance]. <br>		<table><tr><td colspan='2'>[[6bxe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Petma Petma]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BXE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BXE FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Petma]]		[[Category: Petma]]
	[[Category: Cooper, M D]]		[[Category: Cooper, M D]]

OCA at 08:03, 21 February 2019

OCA — Thu, 21 Feb 2019 08:03:02 GMT

←Older revision		Revision as of 08:03, 21 February 2019
Line 3:		Line 3:
	<StructureSection load='6bxe' size='340' side='right' caption='[[6bxe]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='6bxe' size='340' side='right' caption='[[6bxe]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6bxe]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BXE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BXE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6bxe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Petma Petma]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BXE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BXE FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bxe OCA], [http://pdbe.org/6bxe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bxe RCSB], [http://www.ebi.ac.uk/pdbsum/6bxe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bxe ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bxe OCA], [http://pdbe.org/6bxe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bxe RCSB], [http://www.ebi.ac.uk/pdbsum/6bxe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bxe ProSAT]</span></td></tr>
	</table>		</table>
Line 15:		Line 15:
	</div>		</div>
	<div class="pdbe-citations 6bxe" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6bxe" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Variable lymphocyte receptor\|Variable lymphocyte receptor]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Petma]]
	[[Category: Cooper, M D]]		[[Category: Cooper, M D]]
	[[Category: Gunn, R J]]		[[Category: Gunn, R J]]

OCA at 06:16, 9 May 2018

OCA — Wed, 09 May 2018 06:16:34 GMT

←Older revision		Revision as of 06:16, 9 May 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6bxe is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of Variable Lymphocyte Receptor 9 (VLR9)==
		+	<StructureSection load='6bxe' size='340' side='right' caption='[[6bxe]], [[Resolution\|resolution]] 1.65Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6bxe]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BXE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BXE FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bxe OCA], [http://pdbe.org/6bxe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bxe RCSB], [http://www.ebi.ac.uk/pdbsum/6bxe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bxe ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Variable lymphocyte receptors (VLRs) are unconventional adaptive immune receptors relatively recently discovered in the phylogenetically ancient jawless vertebrates, lamprey and hagfish. VLRs bind antigens using a leucine-rich repeat fold and are the only known adaptive immune receptors that do not utilize an immunoglobulin fold for antigen recognition. While immunoglobulin antibodies have been studied extensively, there are comparatively few studies on antigen recognition by VLRs, particularly for protein antigens. Here we report isolation, functional and structural characterization of three VLRs that bind the protein toll-like receptor 5 (TLR5) from zebrafish. Two of the VLRs block binding of TLR5 to its cognate ligand flagellin in functional assays using reporter cells. Co-crystal structures revealed that these VLRs bind to two different epitopes on TLR5, both of which include regions involved in flagellin binding. Our work here demonstrates that the lamprey adaptive immune system can be used to generate high-affinity VLR clones that recognize different epitopes and differentially impact natural ligand binding to a protein antigen.

-	~~Authors~~:	+	VLR Recognition of TLR5 Expands the Molecular Characterization of Protein Antigen Binding by Non-Ig-based Antibodies.,Gunn RJ, Herrin BR, Acharya S, Cooper MD, Wilson IA J Mol Biol. 2018 Apr 27;430(9):1350-1367. doi: 10.1016/j.jmb.2018.03.016. Epub, 2018 Mar 26. PMID:29596914<ref>PMID:29596914</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 6bxe" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Cooper, M D]]
		+	[[Category: Gunn, R J]]
		+	[[Category: Herrin, B R]]
		+	[[Category: Wilson, I A]]
		+	[[Category: Immune receptor]]
		+	[[Category: Immune system]]
		+	[[Category: Lamprey antibody]]
		+	[[Category: Leucine-rich repeat]]
		+	[[Category: Vlr]]

OCA at 17:15, 24 January 2018

OCA — Wed, 24 Jan 2018 17:15:11 GMT

←Older revision		Revision as of 17:15, 24 January 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6bxe is ON HOLD	+	The entry 6bxe is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6bxe" [edit=sysop:move=sysop]

OCA — Wed, 27 Dec 2017 07:20:51 GMT

Protected "6bxe" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:20, 27 December 2017

OCA: New page: '''Unreleased structure''' The entry 6bxe is ON HOLD Authors: Description: Category: Unreleased Structures

OCA — Wed, 27 Dec 2017 07:20:49 GMT

New page: '''Unreleased structure''' The entry 6bxe is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6bxe is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]